Coordinating Center for Population-based Research to Optimize Cancer Screening (PROSPR) (U24)

项目摘要 癌症筛查是一个复杂的、多步骤的过程，当每一步都完成时，好处就会最大化 成功，但由于任何可能发生的故障而导致次优结果频繁出现 在这一过程中起到关键作用。筛查也受到不只是个别患者的因素的影响--包括因素 在提供者、实践和健康计划/机构级别，这些所谓的系统级别的因素可以 影响适当提供高质量的癌症筛查服务。PROSPR的成立是为了解决 与在美国提供癌症筛查有关的一些关键问题，以及我们的 PROSPR第一次统计协调中心是这一倡议许多成功的核心，包括：1) 开发跨器官癌症筛查过程的概念模型，2)创建通用数据 要素和筛选绩效指标；3)评估个人和系统层面的影响因素 筛选业绩，4)跨网络发表的21篇论文的作者身份和统计支助，2 审查，17个正在准备；以及5)建立PROSPR数据存储库并为 公开共享PROSPR数据。我们的PCC团队在大型企业的领导方面拥有丰富的专业知识 协调中心和与PROSPR相关的每个科学领域，包括卫生服务/卫生 护理提供、实施科学、癌症流行病学、健康差距研究、生物统计学、 生物信息学/卫生信息技术，以及结直肠癌、宫颈癌和肺癌的筛查。因此， 我们处于得天独厚的地位，能够成功地执行该协调中心的所有组成部分。具体的 我们委员会的目标是：1)为PROSPR网络提供行政协调，并在 发展PROSPR的治理、组织和政策/程序；2)领导发展 共同概念和衡量标准：a.评估影响 筛选过程。B.评估筛查质量；3)促进跨PROSPR研究 至少2个器官部位的筛查程序；以及4)制定和实施程序和程序，以 与PROSPR网络之外的合格调查人员共享PROSPR数据。相关性：改进 宫颈癌、结直肠癌和肺癌的筛查过程和筛查质量都将降低。 在美国，与这些癌症相关的死亡率、发病率和医疗费用。

Project Summary Cancer screening is a complex, multi-step process where benefits are maximized when each step is completed successfully, but where sub-optimal outcomes are frequent as a result of breakdowns that can happen at any point in this process. Screening is also impacted by factors beyond simply individual patients—including factors at the provider-, practice-, and health plan/institution-level—and these so-called systems level factors can impact the appropriate delivery of high quality cancer screening services. PROSPR was established to address a number of critical questions related to the delivery of cancer screening in the United States, and our PROSPR I Statistical Coordinating Center was central to many of the successes of this initiative including: 1) Developing a trans-organ conceptual model of cancer screening processes, 2) Creating common data elements and screening performance metrics, 3) Evaluating individual and systems-level factors impacting screening performance, 4) Authorship and statistical support on 21 trans-network published papers, 2 under review, and 17 in preparation; and 5) Establishing PROSPR data repositories and creating an infrastructure for publicly sharing PROSPR data. Our PCC team has considerable expertise both in the leadership of large coordinating centers and in each of the scientific fields relevant to PROSPR including health services/health care delivery, implementation science, cancer epidemiology, health disparities research, biostatistics, bioinformatics/health information technology, and the screening of colorectal, cervical, and lung cancers. Thus, we are uniquely positioned to successfully execute all components of this coordinating center. The specific aims of our PCC are to: 1) Provide administrative coordination for the PROSPR network and guidance in the development of PROSPR’s governance, organization, and policies/procedures; 2) Lead the development of common conceptualization and measures for: A. Assessing the role of systems-level factors that impact the screening process. B. Assessing screening quality; 3) Facilitate trans-PROSPR research comparing the screening process across at least 2 organ sites; and 4) Develop and implement processes and procedures to share PROSPR data with qualified investigators outside of the PROSPR network. RELEVANCE: Improving both the screening process and screening quality for cervical, colorectal, and lung cancers will reduce mortality, morbidity, and health care costs associated with these cancers in the United States.