Coordinating Center for Population-based Research to Optimize Cancer Screening (PROSPR) (U24)

优化癌症筛查人群研究协调中心 (PROSPR) (U24)

• 批准号: 10642674
• 负责人: Christopher I Li
• 金额: $ 64.27万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642674
• 关键词: Address; Administrative Coordination; Advisory Committees; Authorship; Bioinformatics; Biometry; Breast Cancer Surveillance Consortium; Cancer Model; Caring; Cervical Cancer Screening; Clinic; Collaborations; Colorectal Cancer; Common Data Element; Complex; Data; Data Analyses; Development; Early Detection Research Network; Effectiveness; Epidemiology; Equity; Evaluation; Health Care Costs; Health Disparities Research; Health Services; Healthcare Systems; Individual; Infrastructure; Institution; Lead; Leadership; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of lung; Measures; Modeling; Monitor; Morbidity - disease rate; Organ; Outcome; Paper; Performance; Persons; Policies; Population Research; Positioning Attribute; Preparation; Procedures; Process; Provider; Publishing; Qualifying; Recording of previous events; Research; Research Personnel; Research Project Grants; Role; Safety; Schedule; Screening for cancer; Site; Statistical Methods; System; Teleconferences; Testing; United States; cancer epidemiology; colorectal cancer screening; data harmonization; data repository; data sharing; experience; health care delivery; health care service organization; health information technology; health plan; implementation science; improved; individual patient; meetings; mortality; multidisciplinary; novel; patient oriented; response; screening; screening participation; screening services; sharing platform; success; working group

Project Summary Cancer screening is a complex, multi-step process where benefits are maximized when each step is completed successfully, but where sub-optimal outcomes are frequent as a result of breakdowns that can happen at any point in this process. Screening is also impacted by factors beyond simply individual patients—including factors at the provider-, practice-, and health plan/institution-level—and these so-called systems level factors can impact the appropriate delivery of high quality cancer screening services. PROSPR was established to address a number of critical questions related to the delivery of cancer screening in the United States, and our PROSPR I Statistical Coordinating Center was central to many of the successes of this initiative including: 1) Developing a trans-organ conceptual model of cancer screening processes, 2) Creating common data elements and screening performance metrics, 3) Evaluating individual and systems-level factors impacting screening performance, 4) Authorship and statistical support on 21 trans-network published papers, 2 under review, and 17 in preparation; and 5) Establishing PROSPR data repositories and creating an infrastructure for publicly sharing PROSPR data. Our PCC team has considerable expertise both in the leadership of large coordinating centers and in each of the scientific fields relevant to PROSPR including health services/health care delivery, implementation science, cancer epidemiology, health disparities research, biostatistics, bioinformatics/health information technology, and the screening of colorectal, cervical, and lung cancers. Thus, we are uniquely positioned to successfully execute all components of this coordinating center. The specific aims of our PCC are to: 1) Provide administrative coordination for the PROSPR network and guidance in the development of PROSPR’s governance, organization, and policies/procedures; 2) Lead the development of common conceptualization and measures for: A. Assessing the role of systems-level factors that impact the screening process. B. Assessing screening quality; 3) Facilitate trans-PROSPR research comparing the screening process across at least 2 organ sites; and 4) Develop and implement processes and procedures to share PROSPR data with qualified investigators outside of the PROSPR network. RELEVANCE: Improving both the screening process and screening quality for cervical, colorectal, and lung cancers will reduce mortality, morbidity, and health care costs associated with these cancers in the United States.

项目摘要 癌症筛查是一个复杂的多步骤过程，在完成每个步骤时，将最大化好处 成功，但是在任何可能发生的崩溃时，次优最佳结果经常是在任何情况下发生的。 在此过程中的意思。筛查还受到简单患者以外的因素（包括因素）的影响 在提供商，实践和健康计划/机构级别，这些所谓的系统级别的因素可以 影响适当的高质量癌症筛查服务。建立了ProSPR来解决 许多关键问题与美国的癌症筛查有关，我们的 ProSPR I统计协调中心是该计划的许多成功的核心，包括：1） 开发跨器械概念模型的癌症筛查过程，2）创建常见数据 元素和筛选性能指标，3）评估影响个人和系统级别的因素 筛选性能，4）21个跨性网络发表论文的作者身份和统计支持，2 审查，准备17个； 5）建立ProSPR数据存储库并为 公开共享ProSPR数据。我们的PCC团队在大型领导方面都拥有大量的专业知识 协调中心以及与PROSPR相关的每个科学领域，包括卫生服务/卫生 护理传递，实施科学，癌症流行病学，健康差异研究，生物统计学， 生物信息学/健康信息技术，以及结直肠，宫颈和肺癌的筛查。那， 我们的位置是成功地执行此协调中心的所有组件。具体 我们的PCC的目的是：1）为PORSPR网络提供行政协调，并在 制定ProSPR的治理，组织和政策/程序； 2）领导发展 共同的概念化和措施：A。评估影响影响的系统级别因素的作用 筛选过程。 B.评估筛选质量； 3）促进跨PR研究比较 筛选至少2个器官位点； 4）开发和实施过程和程序 与ProSPR网络之外合格的研究人员共享PROSPR数据。相关性：改善 宫颈，结直肠癌和肺癌的筛查过程和筛查质量都会减少 在美国，与这些癌症相关的死亡率，发病率和医疗保健费用。

项目成果

Provider- and Facility-Level Variation in Precancerous Cervical Biopsy Diagnoses.

癌前宫颈活检诊断中的提供者和设施水平差异。

• DOI: 10.1097/lgt.0000000000000721
• 发表时间: 2023
• 期刊: Journal of lower genital tract disease
• 影响因子: 3.7
• 作者: DelVecchio,NatalieJ;Beaber,ElisabethF;Garcia,MichaelP;Wheeler,CosetteM;Kamineni,Aruna;Chao,Chun;Chubak,Jessica;Corley,DouglasA;Owens,ChristopherL;Winer,RachelL;Pruitt,SandiL;Raine-Bennett,Tina;Feldman,Sarah;Silverberg,M
• 通讯作者: Silverberg,M

De-implementation of cervical cancer screening before age 21.

• DOI: 10.1016/j.ypmed.2021.106815
• 发表时间: 2021-12
• 期刊: Preventive medicine
• 影响因子: 5.1
• 作者: Silver MI;Anderson ML;Beaber EF;Haas JS;Kobrin S;Pocobelli G;Skinner CS;Tiro JA;Kamineni A
• 通讯作者: Kamineni A