Coordinating Center for Population-based Research to Optimize Cancer Screening (PROSPR) (U24)

优化癌症筛查人群研究协调中心 (PROSPR) (U24)

• 批准号: 10380156
• 负责人: Christopher I Li
• 金额: $ 82.22万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10380156
• 关键词: Address; Administrative Coordination; Advisory Committees; Authorship; Bioinformatics; Biometry; Breast Cancer Surveillance Consortium; Cancer Model; Caring; Cervical Cancer Screening; Clinic; Colorectal Cancer; Common Data Element; Complex; Data; Data Analyses; Development; Early Detection Research Network; Effectiveness; Epidemiology; Evaluation; Health Care Costs; Health Disparities Research; Health Services; Healthcare Systems; Individual; Infrastructure; Institution; Lead; Leadership; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of lung; Measures; Modeling; Monitor; Morbidity - disease rate; Organ; Organizational Policy; Outcome; Paper; Patients; Performance; Persons; Population Research; Positioning Attribute; Preparation; Procedures; Process; Provider; Publishing; Reaction Time; Recording of previous events; Research; Research Personnel; Research Project Grants; Role; Safety; Schedule; Screening for cancer; Site; Statistical Methods; System; Teleconferences; Testing; Time; United States; cancer epidemiology; colorectal cancer screening; data harmonization; data repository; data sharing; experience; health care delivery; health care service organization; health information technology; health plan; implementation science; improved; individual patient; meetings; mortality; multidisciplinary; novel; screening; screening participation; screening services; sharing platform; success; working group

Project Summary Cancer screening is a complex, multi-step process where benefits are maximized when each step is completed successfully, but where sub-optimal outcomes are frequent as a result of breakdowns that can happen at any point in this process. Screening is also impacted by factors beyond simply individual patients—including factors at the provider-, practice-, and health plan/institution-level—and these so-called systems level factors can impact the appropriate delivery of high quality cancer screening services. PROSPR was established to address a number of critical questions related to the delivery of cancer screening in the United States, and our PROSPR I Statistical Coordinating Center was central to many of the successes of this initiative including: 1) Developing a trans-organ conceptual model of cancer screening processes, 2) Creating common data elements and screening performance metrics, 3) Evaluating individual and systems-level factors impacting screening performance, 4) Authorship and statistical support on 21 trans-network published papers, 2 under review, and 17 in preparation; and 5) Establishing PROSPR data repositories and creating an infrastructure for publicly sharing PROSPR data. Our PCC team has considerable expertise both in the leadership of large coordinating centers and in each of the scientific fields relevant to PROSPR including health services/health care delivery, implementation science, cancer epidemiology, health disparities research, biostatistics, bioinformatics/health information technology, and the screening of colorectal, cervical, and lung cancers. Thus, we are uniquely positioned to successfully execute all components of this coordinating center. The specific aims of our PCC are to: 1) Provide administrative coordination for the PROSPR network and guidance in the development of PROSPR’s governance, organization, and policies/procedures; 2) Lead the development of common conceptualization and measures for: A. Assessing the role of systems-level factors that impact the screening process. B. Assessing screening quality; 3) Facilitate trans-PROSPR research comparing the screening process across at least 2 organ sites; and 4) Develop and implement processes and procedures to share PROSPR data with qualified investigators outside of the PROSPR network. RELEVANCE: Improving both the screening process and screening quality for cervical, colorectal, and lung cancers will reduce mortality, morbidity, and health care costs associated with these cancers in the United States.

项目摘要 癌症筛查是一个复杂的多步骤过程，当每一步完成时， 成功地，但次优的结果是经常作为故障的结果，可能发生在任何 在这个过程中。筛查还受到不仅仅是单个患者的因素的影响，包括 在提供者、实践和健康计划/机构层面，这些所谓的系统层面因素可以 影响高质量癌症筛查服务的适当提供。PROSPR的建立是为了解决 一些关键的问题，有关提供癌症筛查在美国，和我们的 PROSPR I统计协调中心是这一举措取得许多成功的核心，包括： 开发癌症筛查过程的跨器官概念模型，2）创建通用数据 要素和筛选性能指标，3）评估个人和系统级影响因素 筛选性能，4）21篇跨网络发表论文的作者身份和统计支持，2篇在 5）建立PROSPR数据储存库，并建立基础设施， 公开分享PROSPR数据。我们的PCC团队在大型企业的领导方面， 协调中心和与PROSPR相关的每个科学领域，包括卫生服务/健康 护理交付，实施科学，癌症流行病学，健康差异研究，生物统计学， 生物信息学/健康信息技术，以及结肠直肠癌、宫颈癌和肺癌的筛查。因此，在本发明中， 我们处于独特的地位，能够成功地执行这个协调中心的所有组成部分。具体 我们的PCC的目标是：1）为PROSPR网络提供行政协调和指导， 制定PROSPR的治理、组织和政策/程序; 2）领导制定 共同的概念和措施：A。评估系统一级因素在影响 筛选过程。B。评估筛选质量; 3）促进跨PROSPR研究， 在至少2个器官研究中心进行筛查;以及4）制定和实施流程和程序， 与PROSPR网络之外的合格研究者共享PROSPR数据。相关性：改善 宫颈癌、结肠直肠癌和肺癌的筛查过程和筛查质量都将降低， 死亡率，发病率，以及与美国这些癌症相关的医疗保健费用。