Administrative Core: Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction

项目总结/摘要 发音功能亢进的预防、诊断和治疗改进临床研究中心 （VHCRC）汇集了一个经验丰富的调查人员组成的多学科团队， 一个专注于功能亢进性嗓音障碍的研究项目。VHCRC由四个研究项目组成， 一个是管理核心（Admin Core），一个是技术和数据科学核心（Tech Core）。研究 该计划将主要由三个机构组成的联合体实施：（1）马萨诸塞州总医院 将服务于VHCRC的领导/主要机构，包括管理核心、技术核心和项目 1（识别物理和行为因素和机制，以改善声音的检测和表型分析） 项目4（使用动态生物反馈改善声带功能亢进的行为治疗） （2）波士顿大学将开展项目2（发声机能亢进的感觉运动机制）; 和（3）Universidad Técnica Federico Santa María将进行项目3（建模生物力学，空气动力学， 发声机能亢进的声学和听觉-运动控制机制）。其他机构通过 分包商包括波士顿医学中心、滑铁卢大学、克拉克森大学和埃默里大学。 行政核心将为整个VHCRC提供全面的行政支持和指导。它将由 项目总监（PD）在行政协调员的协助下。管理员履行的职责 核心包括：1）履行与VHCRC运作有关的所有财务职能，2）监督和 确保遵守所有人类研究法规，3）向NIH提交年度进展报告，4） 安排和举行所有参与VHCRC的研究者的定期会议，以优化 研究计划的凝聚力，整合性和效率，以及5）定期综合评估 VHCRC及其组件。在行政结构方面，项目和技术核心报告的PI 直接向PD提交，PD在解决无法通过以下方式解决的争议或分歧方面拥有最终权力 共识除了整个研究团队的定期会议外，所有项目和核心的PD和PI (with根据需要选定的顾问）将每年与一个由主要顾问组成的咨询委员会举行会议。 与VHCRC项目相关领域的专家。该咨询委员会将积极参与评价工作 和规划过程，包括评估科学进展和优化战略， 在赠款过程中达到总体研究目标。 行政核心被认为是至关重要的成功，VHCRC在实现其总体长期目标， 提高预防，诊断和治疗功能亢进的声音障碍。

Project Summary/Abstract The Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction (VHCRC) brings together a multidisciplinary team of experienced investigators to pursue a comprehensive program of research focused on hyperfunctional voice disorders. The VHCRC consists of four research projects, an Administrative Core (Admin Core), and a Technology and Data Science Core (Tech Core). The research program will be conducted primarily by a consortium of three institutions: (1) Massachusetts General Hospital will serve are the lead/primary institution for the VHCRC and includes the Admin Core, Tech Core, and Project 1 (Identifying physical and behavioral factors and mechanisms to improve detection and phenotyping of vocal hyperfunction) and Project 4 (Use of ambulatory biofeedback to improve behavioral treatment of vocal hyperfunction); (2) Boston University will conduct Project 2 (Sensorimotor mechanisms of vocal hyperfunction); and (3) Universidad Técnica Federico Santa María will conduct Project 3 (Modeling biomechanical, aero- acoustic and auditory-motor control mechanisms of vocal hyperfunction). Additional institutions involved via subcontracts include Boston Medical Center, University of Waterloo, Clarkson University, and Emory University. The Admin Core will provide overall administrative support and direction for the entire VHCRC. It will be led by the Program Director (PD) with assistance from an Administrative Coordinator. Duties performed by the Admin Core include 1) performing all financial functions related to the operation of the VHCRC, 2) overseeing and ensuring compliance with all human studies regulations, 3) submission of annual progress reports to NIH, 4) scheduling and conducting regular meetings of all of the investigators participating in the VHCRC to optimize the cohesion, integration, and efficiency of the research program, and 5) periodic comprehensive evaluation of the VHCRC and its components. In terms of administrative structure, the PIs of the projects and Tech Core report directly to the PD who has final authority in settling disputes or disagreements that cannot be resolved by consensus. In addition to regular meetings of the entire research team, the PD and PIs of all projects and cores (with selected consultants as deemed necessary) will meet annually with an Advisory Committee of leading experts in areas related to VHCRC projects. This Advisory Committee will be actively involved in the evaluation and planning process of the VHCRC, including evaluating the scientific progress and optimizing strategies to meet the overall research goals over the course of the grant award. The Admin Core is considered critical to the success of the VHCRC in achieving its overall long-term goal of improving the prevention, diagnosis, and treatment of hyperfunctional voice disorders.