Administrative Core: Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction

行政核心：声乐功能亢进预防、诊断和治疗临床研究中心

• 批准号: 10639610
• 负责人: Robert E Hillman
• 金额: $ 49.83万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10639610
• 关键词: Advisory Committees; Area; Auditory; Authorization documentation; Award; Behavior Therapy; Behavioral; Biofeedback; Boston; Budgets; Clinical Research; Communication; Consensus; Consent; Data; Data Science Core; Detection; Diagnosis; Disputes; Documentation; Ensure; Evaluation; Expenditure; Failure; General Hospitals; Goals; Grant; Guidelines; Human; Individual; Institution; Institutional Review Boards; Journals; Lead; Massachusetts; Medical center; Modeling; Monitor; Names; Participant; Patient Recruitments; Peer Review; Periodicals; Persons; Phenotype; Prevention; Problem Solving; Process; Progress Reports; Protocols documentation; Publications; Publishing; Regulation; Reporting; Research; Research Personnel; Research Project Grants; Resources; Running; Schedule; Site; Structure; Technology; Teleconferences; Time; United States National Institutes of Health; Universities; Voice; Voice Disorders; authority; biomechanical model; cohesion; data collection site; experience; improved; meetings; motor control; multidisciplinary; operation; payment; programs; protocol violation; success; symposium; timeline; virtual

Project Summary/Abstract The Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction (VHCRC) brings together a multidisciplinary team of experienced investigators to pursue a comprehensive program of research focused on hyperfunctional voice disorders. The VHCRC consists of four research projects, an Administrative Core (Admin Core), and a Technology and Data Science Core (Tech Core). The research program will be conducted primarily by a consortium of three institutions: (1) Massachusetts General Hospital will serve are the lead/primary institution for the VHCRC and includes the Admin Core, Tech Core, and Project 1 (Identifying physical and behavioral factors and mechanisms to improve detection and phenotyping of vocal hyperfunction) and Project 4 (Use of ambulatory biofeedback to improve behavioral treatment of vocal hyperfunction); (2) Boston University will conduct Project 2 (Sensorimotor mechanisms of vocal hyperfunction); and (3) Universidad Técnica Federico Santa María will conduct Project 3 (Modeling biomechanical, aero- acoustic and auditory-motor control mechanisms of vocal hyperfunction). Additional institutions involved via subcontracts include Boston Medical Center, University of Waterloo, Clarkson University, and Emory University. The Admin Core will provide overall administrative support and direction for the entire VHCRC. It will be led by the Program Director (PD) with assistance from an Administrative Coordinator. Duties performed by the Admin Core include 1) performing all financial functions related to the operation of the VHCRC, 2) overseeing and ensuring compliance with all human studies regulations, 3) submission of annual progress reports to NIH, 4) scheduling and conducting regular meetings of all of the investigators participating in the VHCRC to optimize the cohesion, integration, and efficiency of the research program, and 5) periodic comprehensive evaluation of the VHCRC and its components. In terms of administrative structure, the PIs of the projects and Tech Core report directly to the PD who has final authority in settling disputes or disagreements that cannot be resolved by consensus. In addition to regular meetings of the entire research team, the PD and PIs of all projects and cores (with selected consultants as deemed necessary) will meet annually with an Advisory Committee of leading experts in areas related to VHCRC projects. This Advisory Committee will be actively involved in the evaluation and planning process of the VHCRC, including evaluating the scientific progress and optimizing strategies to meet the overall research goals over the course of the grant award. The Admin Core is considered critical to the success of the VHCRC in achieving its overall long-term goal of improving the prevention, diagnosis, and treatment of hyperfunctional voice disorders.

项目摘要/摘要 改进发声功能亢进预防、诊断和治疗的临床研究中心 (VHCRC)汇集了一支由经验丰富的多学科调查人员组成的团队，以追求全面的 该项目的研究重点是功能亢进性嗓音障碍。VHCRC由四个研究项目组成， 管理核心(管理核心)和技术和数据科学核心(技术核心)。这项研究 该计划将主要由三个机构组成的财团实施：(1)马萨诸塞州综合医院 将担任VHCRC的领导/主要机构，包括管理核心、技术核心和项目 1)确定物理和行为因素和机制，以改进声带的检测和表型 功能亢进)和项目4(使用动态生物反馈改善发声的行为治疗 (2)波士顿大学将实施项目2(声带功能亢进的感觉运动机制)； Técnica Federico Santa María大学将开展项目3(建模生物力学、空气动力学、 发声功能亢进的声学和听觉运动控制机制)。更多参与机构，通过 分包合同包括波士顿医学中心、滑铁卢大学、克拉克森大学和埃默里大学。 管理核心将为整个VHCRC提供全面的行政支持和指导。它将由以下人员领导 项目主任(PD)在行政协调员的协助下。管理员履行的职责 核心包括1)履行与VHCRC运作有关的所有财务职能，2)监督和 确保遵守所有人体研究法规，3)向国家卫生研究院提交年度进展报告，4) 安排和主持所有参加VHCRC的调查人员的定期会议，以优化 研究计划的凝聚力、整合性和效率；5)定期对 VHCRC及其组件。在管理结构方面，项目的绩效指标和技术核心报告 直接提交给PD，后者拥有最终权力解决无法通过以下方式解决的争议或分歧 达成共识。除了整个研究小组的定期会议外，所有项目和核心的PD和PI (视需要选定顾问)将每年与一个咨询委员会举行会议，咨询委员会由 VHCRC项目相关领域的专家。本咨询委员会将积极参与评价工作 和规划过程，包括评估科学进步和优化战略，以 在整个授予过程中达到总体研究目标。 管理核心被认为是VHCRC成功实现其总体长期目标的关键 提高对功能性发声障碍的预防、诊断和治疗水平。