Clinical Research Core (RC 1)

项目摘要 临床研究核心（RC 1）是佛罗里达大学（UF）老年美国人成功的关键 独立中心（OAIC）。RC 1为开展临床研究提供资源和专业知识 在临床试验调查以及风险和结局的观察性研究的范围内 与流动性和预防残疾有关。其主要目标是鼓励和促进临床 在这个领域的翻译研究。 RC 1有三个具体目标： 目标1：提供资源和智力环境，以促进临床研究，团队科学， OAIC青年学者的教育与流动性和预防残疾有关。 目标2：促进和便利将临床前研究和试点研究转化为老年人临床试验。 目标3：提高我们对可能影响反应的行为、认知和生理因素的理解 旨在改善行动能力和预防老年人残疾的干预措施。 RC 1作为中心枢纽发挥作用，所有OAIC核心的专业知识、数据和产品都汇聚于此， 产生研究项目，从试点/探索和发展项目，到更大的第二，第三阶段， 和IV与行动和预防残疾有关的功效和有效性试验。RC 1提供 资源和人员（包括U 01和R 01资助的研究人员），以支持开发和 实施临床试验。这些措施包括药物、营养和行为干预， 老年人运动障碍原因的观察性研究及其对功能性疾病的影响 衰退和残疾。在与其他OAIC核心密切合作的基础上，RC 1将支持 试点/探索性项目、开发性项目和外部项目。此外，高级调查员 将担任职业发展导师，带领这些计划， 专业知识，并促进初级教师的研究以及高级教师的合作丰富的环境。

PROJECT SUMMARY The Clinical Research Core (RC1) is key to the success of the University of Florida (UF) Older Americans Independence Center (OAIC). The RC1 provides the resources and expertise for conducting clinical research across the spectrum of investigation of clinical trials as well as observational studies of risk and outcomes related to mobility and the prevention of disability. Its primary goal is to encourage and facilitate clinical translational research in this area. The RC1 has three Specific Aims: Aim 1: Provide the resources and intellectual environment to facilitate clinical research, team science, and OAIC Junior Scholars' education related to mobility and the prevention of disability. Aim 2: Promote and facilitate the translation of preclinical and pilot studies into clinical trials in older persons. Aim 3: Improve our understanding of behavioral, cognitive, and physiological factors that may affect responses to interventions designed to improve mobility and prevent disability in older adults. The RC1 functions as the central hub to which the expertise, data and products of all OAIC cores converge to produce research projects ranging from pilot/ exploratory and developmental projects, to larger Phase II, III, and IV efficacy and effectiveness trials related to mobility and prevention of disability.The RC1 provides resources and personnel (including U01- and R01-funded investigators) to support the development and implementation of clinical trials. These include pharmacologic, nutritional, and behavioral interventions, and observational studies of the causes of mobility impairment in older adults and the implications for functional decline and disability. Building on close collaborations with other OAIC cores, the RC1 will support pilot/exploratory projects, developmental projects, and external projects. In addition, senior-level investigators with established track record will serve as career-development mentors to lead these projects, provide expertise, and promote a rich environment for junior-faculty research as well as senior-faculty collaboration.