The University of Florida Jacksonville Aging Studies Center (JAX-ASCENT)

摘要 少数族裔和低社会经济地位的老年人具有特别高的风险 服务不足且在临床研究中的代表性严重不足的人群。这导致了一种 关于适当和/或最佳预防和治疗方法的知识差距 风险组。在佛罗里达州内，杰克逊维尔市(JAX)的少数民族比例很高，而少数族裔比例较低 自闭症患者。通过扩大其日本宇宙航空研究开发机构关于老龄化和健康差距的现有研究合作 网站上，佛罗里达大学(UF)有一个独特的机会来进行重要的研究，以减少这种 知识鸿沟。这些现有的关系包括合作开展由美国国立卫生研究院资助的多中心临床 试验，以及在UF盖恩斯维尔(GNV)和日本宇宙航空研究开发机构的几项社区外联努力。然而，还有 目前没有有凝聚力的、有组织的资源来整合这些重要的老龄化和 UF-JAX的健康差距。在UF GNV园区，我们拥有强大的临床翻译研究 克劳德·D·佩珀老年美国人独立中心的基础设施，临床翻译科学 研究所和差异研究。在JAX，UF在人口稠密的少数民族拥有一家大型医疗机构 和低SES地区，但有限的研究基础设施集中在老龄化研究。全面落实 为了挖掘这一非凡资源的潜力，我们建议建立一个专门的老龄化研究中心，专注于 少数族裔和低SES老年人。这一最先进的临床转化研究设施 多学科研究杰克逊维尔老龄研究中心(JAX-ASCENT)将与UF密切合作 并充分利用我们的专业知识和资源。此外，JAX-Ascent将创建一个 综合体力和智力环境，各级学员和来自不同领域的科学家 学科可以相互作用，并进行关于衰老和独立性的临床和行为翻译研究 年长的成年人。这一重点将使用跨越广泛领域的跨学科方法来进行 生物医学调查，包括临床研究，行为科学，社会科学，流行病学， 生物统计和卫生服务，同时在研究中实行严谨和透明。我们将发展和 关于老年人临床试验、招募、依从性、保留、评估方面的专业知识的合作伙伴 结果、生物标记物和行为研究都集中在城市少数民族和低收入人群的研究上，并为其量身定做 自闭症老年人。我们将应用基于社区的参与性研究的概念/逻辑模型 伙伴关系，以改善社区参与和健康成果，并建立一个研究参与者 注册表。我们将发展物质和人力基础设施，指导初级教师发挥领导作用， 并让JAX的上升变得自给自足。JAX-Avcent将扩展临床翻译方面的知识 在研究程度较低的人群中进行研究，既扩大和丰富了老年人研究的多样性 密歇根大学少数民族人口、临床有效性、结果和社区参与计划。

Summary Older adults of racial minorities and low socioeconomic (SES) status represent particularly high risk populations who are underserved and are significantly underrepresented in clinical research. This has led to a gap in knowledge regarding the appropriate and/or optimal prevention and treatment approaches for this high risk group. Within the state of Florida, the city of Jacksonville (JAX) has a high proportion of minority and low SES individuals. By expanding existing research collaborations on both aging and health disparities at its JAX site, the University of Florida (UF) has a unique opportunity to conduct important research that can reduce this knowledge gap. These existing relationships include partnership in conducting multi-center NIH-funded clinical trials, along with several community outreach efforts both at UF Gainesville (GNV) and JAX. However, there is currently no cohesive, organized resource to integrate these important research collaborations in aging and health disparities at UF-JAX. At the UF GNV campus, we have a strong clinical translational research infrastructure with the Claude D. Pepper Older Americans Independence Center, Clinical Translational Science Institute and Disparities Research. In JAX, UF has a large health care facility in a densely populated minority and low SES area, but limited research infrastructure focused on aging research. To fully actualize the potential of this remarkable resource, we propose to develop a dedicated center for aging research focused on racial minorities and low SES older adults. This state-of-the-art clinical translational research facility for multidisciplinary research Jacksonville Aging Studies CENTer (JAX-ASCENT) will closely partner with the UF GNV campus and capitalize on our expertise and resources. Additionally, JAX-ASCENT will create an integrative physical and intellectual environment in which trainees at all levels and scientists from diverse disciplines can interact and conduct clinical and behavioral translational research on aging and independence of older adults. This focus will be pursued using an interdisciplinary approach that traverses a broad spectrum of biomedical investigation, including clinical research, behavioral sciences, social sciences, epidemiology, biostatistics, and health services, while implementing rigor and transparency in research. We will develop and partner regarding expertise on clinical trials, recruitment, adherence, retention, assessment of geriatric outcomes, biomarkers, and behavioral studies all focused and tailored on research in urban minorities and low SES older adults. We will apply a conceptual/logic model of community-based participatory research partnerships to improve community involvement and health outcomes, and to build a research participants registry. We will develop the physical and human infrastructure, mentor junior faculty towards leadership roles, and have JAX-ASCENT become self-sustaining. JAX-ASCENT will expand knowledge in clinical translational research in largely understudied populations and both enlarge and enrich the diversity of research in older minority populations, clinical effectiveness, outcomes, and community engagement programs at UF.