The University of Florida Jacksonville Aging Studies Center (JAX-ASCENT)

总结 少数民族和社会经济地位低的老年人风险特别高 在临床研究中服务不足和代表性明显不足的人群。这导致 对这种高风险的适当和/或最佳预防和治疗方法的认识存在差距 风险组。在佛罗里达州内，杰克逊维尔市（JAX）的少数族裔比例很高， SES个人。通过扩大现有的研究合作，在其JAX的老龄化和健康差距 网站，佛罗里达大学（UF）有一个独特的机会进行重要的研究，可以减少这一点 知识差距。这些现有的关系包括在进行多中心NIH资助的临床研究方面的合作伙伴关系。 试验，沿着几个社区外展工作都在UF盖恩斯维尔（GNV）和JAX。不过有 目前没有凝聚力，有组织的资源，以整合这些重要的研究合作，在老龄化和 UF-JAX的健康差异。在UF GNV校园，我们有一个强大的临床转化研究 基础设施与克劳德D. Pepper老年美国人独立中心，临床转化科学 研究所和差异研究。在JAX，UF在人口稠密的少数民族中拥有大型医疗保健设施 和低SES地区，但有限的研究基础设施集中在老龄化研究。为了充分实现 这一显着的资源潜力，我们建议开发一个专门的中心，为老龄化研究的重点， 少数民族和低社会经济地位的老年人。这个最先进的临床转化研究机构， 多学科研究杰克逊维尔老龄化研究中心（JAX-ASCENT）将与用友密切合作 GNV校园和利用我们的专业知识和资源。此外，JAX-ASCENT将创建一个 综合性的物质和智力环境，各级受训人员和来自不同领域的科学家 学科可以相互作用，并进行临床和行为转化研究老化和独立 的老年人。这一重点将采用跨学科的方法，跨越广泛的 生物医学调查，包括临床研究，行为科学，社会科学，流行病学， 生物统计和卫生服务，同时在研究中实施严格和透明。创新和 在临床试验、招募、依从性、保留、老年人评估方面的专业知识方面的合作伙伴 结果，生物标志物和行为研究都集中在城市少数民族和低收入群体的研究上， SES老年人。我们将应用基于社区的参与式研究的概念/逻辑模型 伙伴关系，以改善社区参与和健康成果，并建立一个研究参与者 注册表我们将发展物质和人力基础设施，指导初级教师发挥领导作用， 让JAX-ASCENT能够自我维持JAX-ASCENT将扩展临床翻译知识 在很大程度上研究不足的人群中进行研究，并扩大和丰富老年人研究的多样性。 少数民族，临床效果，结果，并在UF社区参与计划。

Summary Older adults of racial minorities and low socioeconomic (SES) status represent particularly high risk populations who are underserved and are significantly underrepresented in clinical research. This has led to a gap in knowledge regarding the appropriate and/or optimal prevention and treatment approaches for this high risk group. Within the state of Florida, the city of Jacksonville (JAX) has a high proportion of minority and low SES individuals. By expanding existing research collaborations on both aging and health disparities at its JAX site, the University of Florida (UF) has a unique opportunity to conduct important research that can reduce this knowledge gap. These existing relationships include partnership in conducting multi-center NIH-funded clinical trials, along with several community outreach efforts both at UF Gainesville (GNV) and JAX. However, there is currently no cohesive, organized resource to integrate these important research collaborations in aging and health disparities at UF-JAX. At the UF GNV campus, we have a strong clinical translational research infrastructure with the Claude D. Pepper Older Americans Independence Center, Clinical Translational Science Institute and Disparities Research. In JAX, UF has a large health care facility in a densely populated minority and low SES area, but limited research infrastructure focused on aging research. To fully actualize the potential of this remarkable resource, we propose to develop a dedicated center for aging research focused on racial minorities and low SES older adults. This state-of-the-art clinical translational research facility for multidisciplinary research Jacksonville Aging Studies CENTer (JAX-ASCENT) will closely partner with the UF GNV campus and capitalize on our expertise and resources. Additionally, JAX-ASCENT will create an integrative physical and intellectual environment in which trainees at all levels and scientists from diverse disciplines can interact and conduct clinical and behavioral translational research on aging and independence of older adults. This focus will be pursued using an interdisciplinary approach that traverses a broad spectrum of biomedical investigation, including clinical research, behavioral sciences, social sciences, epidemiology, biostatistics, and health services, while implementing rigor and transparency in research. We will develop and partner regarding expertise on clinical trials, recruitment, adherence, retention, assessment of geriatric outcomes, biomarkers, and behavioral studies all focused and tailored on research in urban minorities and low SES older adults. We will apply a conceptual/logic model of community-based participatory research partnerships to improve community involvement and health outcomes, and to build a research participants registry. We will develop the physical and human infrastructure, mentor junior faculty towards leadership roles, and have JAX-ASCENT become self-sustaining. JAX-ASCENT will expand knowledge in clinical translational research in largely understudied populations and both enlarge and enrich the diversity of research in older minority populations, clinical effectiveness, outcomes, and community engagement programs at UF.