Clinical Research Core

项目总结 临床研究核心(RC1)是佛罗里达大学(UF)老年美国人的关键资源 独立中心(OAIC)，为在世界各地开展研究提供资源和专业知识 临床研究的范围，包括临床试验以及对生物和 与促进机动性和独立性相关的行为因素。核心的主要目标是 鼓励和促进侧重于促进机动性和独立性的临床转化研究。 RC1有三个具体目标： 1.目标1：提供资源和智力环境，促进临床研究、团队科学、 和教育OAIC REC学者，包括任职人数不足的调查人员，与晋升有关 机动性和独立性。 2.目标2：促进和便利将临床前和试点研究转化为老年临床试验 考虑到性别和族裔/种族的人。 3.目标3：提高我们对行为、生物、认知和社会/环境因素的理解， 由于重点关注健康差距，这可能会影响对旨在促进 老年人的机动性和独立性。 RC1提供资源和人员(包括U01和R01 NIH资助的调查人员)，以支持 开发和实施临床试验，包括药理学、营养学和行为学 针对老年人行动能力障碍因素的干预和观察性研究 以及对功能衰退和残疾的影响。在与OAIC其他核心密切合作的基础上， RC1将支持试点/探索性项目、发展项目和外部项目。核心意志 还为高级调查人员提供既定的跟踪记录，作为研究教育的导师来领导 这些目标中的每一个都为早期教师研究和促进提供专业知识和丰富的环境 资深教员协作。

PROJECT SUMMARY The Clinical Research Core (RC1) is a key resource for the University of Florida (UF) Older Americans Independence Center (OAIC), providing the resources and expertise for conducting research across the spectrum of clinical investigation, including clinical trials, as well as observational studies of biological and behavioral factors related to promotion of mobility and independence. The Core’s primary goal is to encourage and facilitate clinical translational research focused on promotion of mobility and independence. The RC1 has three Specific Aims: 1. Aim 1: Provide the resources and intellectual environment to facilitate clinical research, team science, and education of OAIC REC Scholars, including under-represented investigators, related to promotion of mobility and independence. 2. Aim 2: Promote and facilitate translation of pre-clinical and pilot studies into clinical trials in older persons with consideration for sex and ethnicity/race. 3. Aim 3: Improve our understanding of behavioral, biological, cognitive, and social/environmental factors, with a focus on health disparities, that may affect responses to interventions, designed to promote mobility and independence in older adults. The RC1 provides resources and personnel (including U01 and R01 NIH funded investigators) to support the development and implementation of clinical trials, including pharmacologic, nutritional and behavioral interventions, and observational studies addressing factors contributing to mobility impairment in older adults and implications for functional decline and disability. Building on close collaborations with other OAIC cores, the RC1 will support pilot/exploratory projects, developmental projects, and external projects. The Core will also provide senior level Investigators with established track records as mentors for research education to lead each of these goals, providing expertise and promoting a rich environment for early stage faculty research and senior faculty collaboration.