Tailoring Recruitment Communication using Virtual Human Technology to Increase Participation of Older Minority Adults in Clinical Trials

项目摘要 老年少数群体是一个得不到充分服务的群体，他们患慢性病的风险特别高， 疾病/健康状况，在临床研究中的代表性明显不足。众所周知的障碍， 包括与研究有关的不信任（例如，认为参与者缺乏选择，不信任白色研究人员），缺乏 CT工作人员的文化多样性/敏感性，以及在决策中排除决策支持提供者- 阻碍老年人少数群体参与CT。定制内容和源偏好要有耐心- 以文化为中心，具有文化敏感性（即，促进舒适，信任，尊重的感觉），并与个人相关的 接受者（患者），从而增加了对他们的态度和行为产生持久影响的可能性， 与老年少数群体的积极健康行为有关。这种剪裁还没有被研究以增加 参与率的老年人进入积极的CT少数民族，虽然文化定制的VHT干预措施， 在少数参与者中被视为值得信赖。我们的长期目标是增加临床试验（CT） 老年少数群体（黑人/非裔美国人（AA），西班牙裔/拉丁裔（H/L））的参与，和/或 50岁以上的农村成年人）使用虚拟人技术（VHT）。在目标1中，我们将集中精力 与年长的成年少数群体，以获得数据，将用于重新设计ALEX文化敏感， 这些少数民族。在目标2中，跟踪这些少数群体在不同的NIH资助的积极CT中的参与情况。 远程传送艾力克斯的方式在目标3中，我们将比较ALEX和标准招聘方法， 将这些少数民族纳入NIH资助的CT。这些项目目标的实现将导致适应性强， 为提高老年人少数群体在活跃社区中的参与率而采取的最低限度定制的VHT招募干预措施 NIH资助的CT。

PROJECT SUMMARY Older adult minorities are an underserved population, who are at a particularly high risk for developing chronic diseases/health conditions and are significantly underrepresented in clinical research. Well-known barriers, including research-related mistrust (e.g., belief that participants lack choice, mistrust of white researchers), lack of cultural diversity/sensitivity among CT staff, and the exclusion of decisional support providers in decision- making impede older adult minority participation in CTs. Tailoring content and source preferences to be patient- centered, culturally sensitive (i.e., promote feelings of comfort, trust, respect), and personally relevant to the receiver (a patient), thus increasing the likelihood of having a lasting effect on their attitudes and behaviors, has been linked to positive health behaviors by older adult minorities. Such tailoring has not been studied to increase participation rates of older adult minorities into active CTs, though culturally tailored VHT interventions are perceived as trustworthy among minority participants. Our long-term goal is to increase clinical trial (CT) participation among older adult minorities (Black/African American (AA), Hispanic/Latinx (H/L), and/or rural adults over the age of 50) using Virtual Human Technology (VHT). In Aim1, we will conduct focus groups with older adult minorities to obtain data that will be used to redesign ALEX to be culturally sensitive for these minorities. In Aim 2, track engagement of such minorities into active, NIH-funded CTs across different modalities for remotely delivering ALEX. In Aim 3, we will compare ALEX and standard recruitment methods for enrolling such minorities into NIH-funded CTs. Achievement of these project aims will result in adaptable, minimally tailored VHT recruitment intervention for increasing older adult minority participation rates in active NIH-funded CTs.