International Collaboration to Develop Scalable Methods for Early Detection of Neurodevelopmental Disorder Due to Prenatal Alcohol Exposure

国际合作开发可扩展的方法来早期检测因产前酒精暴露引起的神经发育障碍

• 批准号: 9770728
• 负责人: CHRISTINA CHAMBERS
• 金额: $ 31.96万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9770728
• 关键词: Address; Affect; Age-Months; Alcohols; Algorithms; Area; Arousal; Biosensor; Brain; Cardiac; Cellular Phone; Child; Clinical; Collaborations; Data; Detection; Diagnosis; Disease; Early Diagnosis; Early Intervention; Early identification; Effectiveness; Emotional; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; High Prevalence; Impaired cognition; Impairment; Individual; Infant; Infant Development; International; Intervention; Lead; Life; Longitudinal cohort study; Measures; Methods; Near-Infrared Spectroscopy; Neurodevelopmental Deficit; Neurodevelopmental Disorder; Neurodevelopmental Impairment; Neuronal Plasticity; Performance; Predictive Value; Prefrontal Cortex; Public Health; Research; Research Methodology; Research Personnel; Resources; Sampling; School-Age Population; Skin; Standardization; Task Performances; Technology; Testing; Toddler; Training; Ukraine; United States; Wireless Technology; Work; base; behavioral outcome; cognitive function; cost; cost efficient; design; early childhood; executive function; flexibility; hemodynamics; improved; improved outcome; indexing; infancy; multidisciplinary; neurophysiology; new technology; novel; point of care; prenatal; public health relevance; rapid detection; rapid technique; response; screening; skills; standard measure; standardize measure

PROJECT SUMMARY Early identification of children who are affected by prenatal exposure to alcohol, i.e., who have Fetal Alcohol Spectrum Disorders (FASD), is essential to initiating early intervention. Early interventions can take advantage of neuroplasticity in young children and thus can improve outcomes for a child with FASD. However, current methods of testing young children for neurodevelopmental impairments are limited in their effectiveness and costly to administer. As a result, many children are not recognized as having FASD and years of appropriate and beneficial intervention or treatment are missed. Given the high prevalence of FASD in areas of the world where the disorder has been studied, earlier and more accurate recognition of children with FASD is of high public health importance. Building on the existing Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD) longitudinal cohort study in Ukraine, we will fill this critical gap by testing three novel, technology- based and scalable methods that can identify impairments in brain functioning in young children. These novel measures can lead to earlier, rapid, more accurate, and cost-efficient detection of neurodevelopmental disorders due to prenatal alcohol. Furthermore, the scalable methods being tested have global

项目摘要 及早发现产前接触酒精的儿童，即，胎儿酒精 频谱障碍（FASD）是早期干预的关键。早期干预可以利用 因此可以改善患有FASD的儿童的结果。但目前的 测试幼儿神经发育障碍的方法在其有效性方面是有限的， 管理成本高。因此，许多儿童没有被确认为患有FASD， 并且错过了有益的干预或治疗。鉴于FASD在世界各地的高发病率 在对这种疾病进行研究的地方，早期和更准确地识别患有FASD的儿童的可能性很高。 公共卫生的重要性。在现有胎儿酒精谱系障碍合作倡议的基础上 （CIFASD）在乌克兰的纵向队列研究，我们将通过测试三种新的技术来填补这一关键空白- 基于和可扩展的方法，可以识别幼儿大脑功能的损伤。这些新颖 这些措施可以更早、更快、更准确、更经济有效地检测神经发育障碍 因为产前酗酒此外，正在测试的可扩展方法具有全局