Manipulating store-operated Ca2+ entry to improve muscle function in dystrophy
Manipulating store-operated Ca2+ entry to improve muscle function in dystrophy
批准号:
nhmrc : 1025355
负责人:
A/Pr Robyn Murphy
金额:
$34.42万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2016-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Muscle function is regulated in a complex manner by calcium and is impaired in Duchenne muscular dystrophy (DMD). Changes in calcium regulation will be investigated in DMD patients and in an animal model using a novel approach. We will use a combination of novel experimental approaches to manipulate muscles in dystrophic mice and test for improvement in function. Results will determine the viability of a potential treatment.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Molecular basis of Ca2+-dependent disruption of EC-coupling and weakness in skeletal muscle
-
批准号:nhmrc : GNT1085331
-
项目类别:Project Grants
-
资助金额:$51.45万
-
财政年份:2015
-
负责人:A/Pr Robyn Murphy
-
依托单位:
Molecular basis of Ca2+-dependent disruption of EC-coupling and weakness in skeletal muscle
-
批准号:nhmrc : 1085331
-
项目类别:Project Grants
-
资助金额:$35.41万
-
财政年份:2015
-
负责人:A/Pr Robyn Murphy
-
依托单位:
Physiological and pathological effects of oxidation on contractile function in skeletal muscle
-
批准号:nhmrc : 1051460
-
项目类别:Project Grants
-
资助金额:$40.9万
-
财政年份:2013
-
负责人:A/Pr Robyn Murphy
-
依托单位:
Regulatory mechanisms and roles of calpains in skeletal muscle
-
批准号:nhmrc : 602538
-
项目类别:NHMRC Project Grants
-
资助金额:$29.33万
-
财政年份:2010
-
负责人:A/Pr Robyn Murphy
-
依托单位:
Investigation of the roles of calcium-dependent proteases in muscle damage and disease
-
批准号:nhmrc : 433034
-
项目类别:NHMRC Project Grants
-
资助金额:$24.02万
-
财政年份:2007
-
负责人:A/Pr Robyn Murphy
-
依托单位:
Characterisation of calpain-3 in skeletal muscle
-
批准号:nhmrc : 380842
-
项目类别:Early Career Fellowships
-
资助金额:$19.49万
-
财政年份:2006
-
负责人:A/Pr Robyn Murphy
-
依托单位:
国内基金
海外基金
KV Store关键技术研究与原型系统实现
-
批准号:61672061
-
项目类别:面上项目
-
资助金额:64.0万元
-
批准年份:2016
-
负责人:杨仝
-
依托单位: