Manipulating store-operated Ca2+ entry to improve muscle function in dystrophy

操纵钙池操纵的 Ca2 进入以改善营养不良时的肌肉功能

• 批准号: nhmrc : 1025355
• 负责人: A/Pr Robyn Murphy
• 金额: $ 34.42万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/manipulating-store-operated-function-dystrophy/110428
• 关键词: Manipulating; store; operated; Ca2+; entry

Muscle function is regulated in a complex manner by calcium and is impaired in Duchenne muscular dystrophy (DMD). Changes in calcium regulation will be investigated in DMD patients and in an animal model using a novel approach. We will use a combination of novel experimental approaches to manipulate muscles in dystrophic mice and test for improvement in function. Results will determine the viability of a potential treatment.

肌肉功能受钙的复杂调节，在杜氏肌营养不良（DMD）中受到损害。钙调节的变化将在DMD患者和动物模型中使用一种新的方法进行研究。我们将使用新的实验方法组合来操纵营养不良小鼠的肌肉，并测试其功能的改善。结果将决定潜在治疗的可行性。