Physiological and pathological effects of oxidation on contractile function in skeletal muscle

氧化对骨骼肌收缩功能的生理和病理影响

• 批准号: nhmrc : 1051460
• 负责人: A/Pr Robyn Murphy
• 金额: $ 40.9万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/physiological-pathological-effects-skeletal-muscle/112216
• 关键词: Physiological; pathological; effects; oxidation; contractile

Reactive oxygen molecules generated within muscle fibres in normal exercise and in pathological conditions, greatly affect muscle function by altering the responsiveness of the contractile proteins. This study investigates how various oxidative stresses affect particular reactive sites on key proteins controlling muscle contraction. The findings should identify key molecular changes involved in normal activity and the role oxidation plays in chronic muscle weakness in particular conditions.

在正常运动和病理条件下，肌纤维内产生的活性氧分子通过改变收缩蛋白的反应性极大地影响肌肉功能。这项研究调查了各种氧化应激如何影响控制肌肉收缩的关键蛋白质上的特定反应位点。这些发现应该确定参与正常活动的关键分子变化以及氧化在特定条件下慢性肌无力中的作用。