Molecular basis of Ca2+-dependent disruption of EC-coupling and weakness in skeletal muscle

EC 偶联 Ca2 依赖性破坏和骨骼肌无力的分子基础

• 批准号: nhmrc : GNT1085331
• 负责人: A/Pr Robyn Murphy
• 金额: $ 51.45万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-basis-ca2-skeletal-muscle/1345616
• 关键词: Molecular; basis; Ca2+; dependent; disruption

One major cause of weakness in skeletal muscle appears to stem from damage to the mechanism controlling release of calcium ions from internal stores and consequent contraction. This project examines whether the damage is due to excessive levels of intracellular calcium ions activating enzymes that cut a particular vital molecule controlling calcium release. The findings could identify a major factor in muscle weakness in muscular dystrophy and other conditions and lead to specific therapies.

骨骼肌无力的一个主要原因似乎源于控制钙离子从内部储存释放的机制的损伤和随之而来的收缩。这个项目检查是否损害是由于细胞内钙离子激活酶，切断一个特定的重要分子控制钙释放水平过高。这些发现可以确定肌肉萎缩症和其他疾病中肌肉无力的主要因素，并导致特定的治疗方法。