Regulatory mechanisms and roles of calpains in skeletal muscle

钙蛋白酶在骨骼肌中的调节机制和作用

• 批准号: nhmrc : 602538
• 负责人: A/Pr Robyn Murphy
• 金额: $ 29.33万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulatory-mechanisms-roles-skeletal-muscle/97695
• 关键词: Regulatory; mechanisms; roles; calpains; skeletal

The objectives are to understand the regulation and roles of calpains, which are proteases that break proteins in the building and repair of skeletal muscle. We will determine targets that calpains cleave and whether their location changes following activation, as well as the cellular factors regulating their activity. In addition, we will obtain information about the specific type of calpain dysfunction that occurs in particular patients with limb girdle muscular dystrophy 2A.

目的是了解钙蛋白酶的调节和作用，钙蛋白酶是在骨骼肌的构建和修复中破坏蛋白质的蛋白酶。我们将确定钙蛋白酶切割的目标，以及它们的位置是否在激活后发生变化，以及调节它们活性的细胞因子。此外，我们还将获得有关发生在肢带型肌营养不良症2A患者中的特定类型的钙蛋白酶功能障碍的信息。