"1/6" Planning for the HEALthy Early Development Study

健康早期发育研究“1/6”规划

• 批准号: 9899542
• 负责人: Lynn T Singer
• 金额: $ 27.08万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9899542
• 关键词: Address; Adolescence; Adolescent; Age; Alcohol or Other Drugs use; Alcohols; Area; Attention; Behavioral; Biological Markers; Brain; Cannabis; Child; Child Development; Childhood; Cognitive; Cohort Studies; Collaborations; Collection; Complex; Data; Development; Emotional; Environment; Environmental Exposure; Epidemic; Ethics; Exposure to; Funding; Future; Goals; Growth; Growth and Development function; Human; Human Development; Individual; Infant; Institution; Leadership; Legal; Life; Link; Longitudinal cohort study; Measurement; Measures; Mental disorders; Methods; National Institute of Drug Abuse; Opioid; Outcome; Performance; Phase; Pregnancy; Prospective cohort study; Protocols documentation; Recommendation; Research; Research Design; Research Personnel; Risk; Sample Size; Sampling; Site; Structure; Techniques; Testing; Time; Tobacco; United States National Institutes of Health; Vulnerable Populations; Woman; Work; cognitive development; critical period; design; early childhood; evidence base; experience; fetal opioid exposure; infancy; innovation; innovative technologies; meetings; middle childhood; neurobehavioral; neuroimaging; new technology; phase 2 study; postnatal; prenatal; prospective; recruit; research study; retention rate; social; synergism; tool; treatment strategy; uptake; working group

PROJECT SUMMARY The Planning for the HEALthy Early Development Study will contribute to the design and recommended protocol for a future large-scale, multi-site research study to prospectively examine human brain, cognitive, behavioral, social and emotional development of children beginning prenatally through ages 9-10, and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of children. The Planning Study will link investigators across 6 research sites who have complementary experience and expertise in the areas that are essential to designing the study. Planning activities will be accomplished using a coordinated set of 10 Working Groups who will work collaboratively to design a sampling and recruitment strategy for a future large-scale study, to identify and recommend strategies for addressing the challenges to ethical recruitment and retention of vulnerable populations, and to develop and test a common protocol for neuroimaging, infant and child assessments, exposure assessment, biospecimen collection, and integration of novel technologies. By the end of the Planning Phase, the 6 Consortium sites will have produced and tested a recommended protocol for the future multi-site study, and will have established feasibility of carrying out the study protocol at each of the 6 linked sites.

项目总结 健康早期发展规划研究将有助于设计和建议 未来一项大规模、多地点研究的协议，以前瞻性地检查人类的大脑、认知、 从产前开始到9-10岁的儿童的行为、社交和情绪发育，以及 确定母亲出生前和出生后物质使用对儿童精神分裂症短期和长期发展的影响 孩子们。规划研究将把6个研究站点的调查人员联系起来，这些站点具有互补性 对设计研究至关重要的领域的经验和专业知识。计划活动将是 使用由10个工作组组成的协调组完成，这些工作组将协作设计样本 和招聘战略，为未来的大规模研究，以确定和建议战略，以解决 在道德上招募和留住弱势人口方面的挑战，以及制定和测试共同的 神经成像、婴儿和儿童评估、暴露评估、生物素采集和 整合新技术。到规划阶段结束时，6个联合体场地将产生 并为未来的多点研究测试了推荐的方案，并将建立 在6个链接站点中的每个站点执行研究方案。