A Non-Contact Optical Patient and Beam Dosimetry System for Continuous in vivo Radiotherapy Verification

用于连续体内放射治疗验证的非接触式光学患者和射束剂量测定系统

• 批准号: 9905137
• 负责人: William Ware
• 金额: $ 100万
• 依托单位: DOSEOPTICS, LLC
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9905137
• 关键词: 3-Dimensional; Anatomy; Back; Body Surface; Breast; Breathing; Clinical; Clinical Research; Computational algorithm; Computer software; Custom; Data; Deposition; Development; Dose; Engineering; Ensure; Event; Goals; Health; Image; Incidence; Infrastructure; Lasers; Lead; Legal patent; Light; Link; Maps; Marketing; Measures; Medical center; Methodology; Monitor; Motion; Multicenter Trials; Optics; Output; Patient-Focused Outcomes; Patients; Phase; Physics; Physiologic pulse; Positioning Attribute; Property; Pulse Rates; Radiation; Radiation Dose Unit; Radiation Oncology; Radiation therapy; Radiometry; Regimen; Resolution; Resources; Risk; Safety; Scanning; Solid; Spatial Frequency Domain Imaging; Stream; Surface; System; Tattooing; Technology; Testing; Time; Tissues; Treatment outcome; Variant; Weight; Work; X-Ray Computed Tomography; base; body position; cherenkov imaging; clinically relevant; cone-beam computed tomography; design; dosimetry; imaging capabilities; imaging system; improved; in vivo; innovation; member; novel strategies; off-patent; optical imaging; patient oriented; patient safety; pilot trial; prototype; quantitative imaging; radiation delivery; real-time images; tissue phantom; tool; treatment planning

Abstract Optical Cherenkov video imaging of body anatomy and dose delivery can be used now to map out radiotherapy beam incidence upon the patient tissue, directly visualizing the radiation dose deposition on the patient in real time. This could serve as a non-contact workflow tool for verification for daily fractionated radiation therapy, allowing capture of all treatments, all the time. DoseOptics has developed the C-Dose™ camera system, capable of real-time imaging, used in on-going clinical studies in radiation oncology at the Dartmouth-Hitchcock Medical Center. The live 2-D images of the radiation beam on the surface of the patient's tissue, will be integrated with real-time optical surface mapping of patient anatomy from surface mapping. To achieve our goals, the mapping system needs specialized gating off during each radiotherapy pulse-on time, allowing Cherenkov image capture at 360 Hz, the pulse rate of the linac. Additionally, to make the C-Dose images quantitatively accurate, a correction for tissue emissivity needs to be added in, and active imaging from the mapping projector and C-Dose camera will provide this. The combined system should have better than 3% accuracy in calibrated Dose linearity, and the combined overlay on the patient anatomy will make the system the most functional yet for beam and patient position dosimetry. This will be all verified in the Phase 1, and then the combined system will be developed for a multicenter trial, testing for the rate of observed incidents in whole breast radiotherapy. The RO- ILS data based indicates that 27% of incidents are discovered during therapy delivery, and so we will test the systems in two centers where the patient alignment practice is different (laser & tattoo alignment, vs optical alignment) and track incidents related to accuracy of beam and body position. In the completion of this work, we will have a completed system ready for regulatory clearance, and have the data required to demonstrate value to the customers, being the radiotherapy team and the patients getting their daily treatment. This project is backed by a considerable amount of prior camera development and a critical commercial/marketing partner, and will produce the worlds first all optical, non-contact imaging dosimetry system. The team members involved have expertise in all aspects of the development and clinical radiotherapy physics needed to make the project succeed. Beyond this specific application of whole breast radiotherapy, there are other key applications in which the system could be useful as well, where the field sizes are large and dynamics and patient positioning are critical.

摘要 身体解剖和剂量输送的光学切伦科夫视频成像现在可以用来绘制放射治疗图 射束入射到患者组织上，直接可视化真实的患者上的辐射剂量沉积 时间这可以用作用于验证每日分次放射治疗的非接触式工作流程工具， 允许捕获所有治疗，所有时间。DoseOptics开发了C-Dose™相机系统，能够 实时成像，用于正在进行的临床研究，在放射肿瘤学在达特茅斯-希区柯克医疗 中心放射束在患者组织表面上的实时2-D图像将与 根据表面映射对患者解剖结构进行实时光学表面映射。为了实现我们的目标， 系统需要在每次放射治疗脉冲开启时间期间专门关闭门控，允许切伦科夫图像捕获 在360 Hz时，直线加速器的脉冲速率。此外，为了使C-Dose图像定量准确， 需要添加对组织发射率的校正，以及来自标测投影仪和C-Dose的主动成像 相机将提供这些。组合系统在校准剂量线性方面的准确度应优于3%， 并且在患者解剖结构上的组合覆盖将使系统对于射束和 患者体位剂量测定。这将在第一阶段得到验证，然后将合并系统 为多中心试验而开发，测试全乳房放疗中观察到的事件率。RO- 基于ILS的数据表明，27%的事件是在治疗过程中发现的，因此我们将测试 两个中心的系统，其中患者对线实践不同（激光和纹身对线，与光学 对准）和跟踪与射束和身体位置的准确性相关的事件。在完成这项工作后，我们 将有一个完整的系统准备监管许可，并有所需的数据，以证明价值 对于客户，即放射治疗团队和接受日常治疗的患者。这个项目是 由大量先前的相机开发和关键的商业/营销合作伙伴支持， 将生产世界上第一个全光学、非接触式成像剂量测定系统。参与的团队成员 在项目开发和临床放射治疗物理学的各个方面都有专业知识 成功除了全乳房放射治疗的这种特定应用之外，还有其他关键应用， 该系统也可以是有用的，其中，射野尺寸大，并且动态和患者定位被 很危险