A Non-Contact Optical Patient and Beam Dosimetry System for Continuous in vivo Radiotherapy Verification

用于连续体内放射治疗验证的非接触式光学患者和射束剂量测定系统

• 批准号: 9905137
• 负责人: William Ware
• 金额: $ 100万
• 依托单位: DOSEOPTICS, LLC
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9905137
• 关键词: 3-Dimensional; Anatomy; Back; Body Surface; Breast; Breathing; Clinical; Clinical Research; Computational algorithm; Computer software; Custom; Data; Deposition; Development; Dose; Engineering; Ensure; Event; Goals; Health; Image; Incidence; Infrastructure; Lasers; Lead; Legal patent; Light; Link; Maps; Marketing; Measures; Medical center; Methodology; Monitor; Motion; Multicenter Trials; Optics; Output; Patient-Focused Outcomes; Patients; Phase; Physics; Physiologic pulse; Positioning Attribute; Property; Pulse Rates; Radiation; Radiation Dose Unit; Radiation Oncology; Radiation therapy; Radiometry; Regimen; Resolution; Resources; Risk; Safety; Scanning; Solid; Spatial Frequency Domain Imaging; Stream; Surface; System; Tattooing; Technology; Testing; Time; Tissues; Treatment outcome; Variant; Weight; Work; X-Ray Computed Tomography; base; body position; cherenkov imaging; clinically relevant; cone-beam computed tomography; design; dosimetry; imaging capabilities; imaging system; improved; in vivo; innovation; member; novel strategies; off-patent; optical imaging; patient oriented; patient safety; pilot trial; prototype; quantitative imaging; radiation delivery; real-time images; tissue phantom; tool; treatment planning

Abstract Optical Cherenkov video imaging of body anatomy and dose delivery can be used now to map out radiotherapy beam incidence upon the patient tissue, directly visualizing the radiation dose deposition on the patient in real time. This could serve as a non-contact workflow tool for verification for daily fractionated radiation therapy, allowing capture of all treatments, all the time. DoseOptics has developed the C-Dose™ camera system, capable of real-time imaging, used in on-going clinical studies in radiation oncology at the Dartmouth-Hitchcock Medical Center. The live 2-D images of the radiation beam on the surface of the patient's tissue, will be integrated with real-time optical surface mapping of patient anatomy from surface mapping. To achieve our goals, the mapping system needs specialized gating off during each radiotherapy pulse-on time, allowing Cherenkov image capture at 360 Hz, the pulse rate of the linac. Additionally, to make the C-Dose images quantitatively accurate, a correction for tissue emissivity needs to be added in, and active imaging from the mapping projector and C-Dose camera will provide this. The combined system should have better than 3% accuracy in calibrated Dose linearity, and the combined overlay on the patient anatomy will make the system the most functional yet for beam and patient position dosimetry. This will be all verified in the Phase 1, and then the combined system will be developed for a multicenter trial, testing for the rate of observed incidents in whole breast radiotherapy. The RO- ILS data based indicates that 27% of incidents are discovered during therapy delivery, and so we will test the systems in two centers where the patient alignment practice is different (laser & tattoo alignment, vs optical alignment) and track incidents related to accuracy of beam and body position. In the completion of this work, we will have a completed system ready for regulatory clearance, and have the data required to demonstrate value to the customers, being the radiotherapy team and the patients getting their daily treatment. This project is backed by a considerable amount of prior camera development and a critical commercial/marketing partner, and will produce the worlds first all optical, non-contact imaging dosimetry system. The team members involved have expertise in all aspects of the development and clinical radiotherapy physics needed to make the project succeed. Beyond this specific application of whole breast radiotherapy, there are other key applications in which the system could be useful as well, where the field sizes are large and dynamics and patient positioning are critical.

摘要 人体解剖和剂量传递的光学切伦科夫视频成像现在可以用于制定放射治疗计划。 射束入射到患者组织上，直接可视化患者身上的辐射剂量沉积 时间到了。这可以用作每日分次放射治疗的验证的非接触式工作流工具， 允许随时捕获所有治疗方法。DoseOptics已经开发出C剂量™相机系统，能够 实时成像，用于达特茅斯-希区柯克医疗中心正在进行的放射肿瘤学临床研究 中心。辐射束在患者组织表面的实时2-D图像将与 从表面映射到患者解剖的实时光学表面映射。为了实现我们的目标，地图 系统需要在每个放射治疗脉冲开启时间内专门关闭，以允许切伦科夫图像捕获 在360赫兹时，为直线加速器的脉搏频率。此外，为了使C剂量图像在数量上准确， 需要添加对组织发射率的校正，以及来自标测投影仪和C剂量的主动成像 摄像机将提供这一点。组合系统在校准剂量线性度方面的精度应优于3%， 而在患者解剖结构上的组合覆盖将使该系统成为BEAM和 病人体位剂量测定。这些都将在阶段1中进行验证，然后组合系统将 为多中心试验开发，测试全乳房放射治疗中观察到的事件发生率。RO- 基于ILS的数据表明，27%的事件是在治疗过程中发现的，因此我们将测试 患者对齐实践不同的两个中心的系统(激光和纹身对齐，与光学对齐 对齐)和跟踪与光束和主体位置的准确性有关的事件。为了完成这项工作，我们 将有一个完整的系统准备好进行监管审批，并拥有展示价值所需的数据 对于客户来说，是放射治疗的团队和患者的日常治疗。这个项目是 有相当多的前期相机开发和关键的商业/营销合作伙伴支持，以及 将生产世界上第一个全光学、非接触式成像剂量测量系统。参与其中的团队成员 在所有方面的发展和临床放射治疗物理所需的专业知识，使该项目 成功。除了全乳房放射治疗的这一具体应用之外，还有其他关键应用 该系统也可能有用，在磁场大小和动态和患者定位 危急时刻。