Optical imaging for radiation therapy dose verification on patients

用于患者放射治疗剂量验证的光学成像

• 批准号: 9132738
• 负责人: William Ware
• 金额: $ 57.17万
• 依托单位: DOSEOPTICS, LLC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9132738
• 关键词: Accidents; Algorithms; Area; Biological; Breast; Calibration; Cancer Patient; Clinical; Clinical Trials; Color; Complex; Computer software; Data; Data Collection; Detection; Development; Devices; Dimensions; Dose; Electrons; Ensure; Equipment; Goals; Head; Health; Human; Image; Imagery; Imaging Device; Imaging technology; Individual; Intensity-Modulated Radiotherapy; Interruption; Intervention; Lateral; Left; Legal patent; Licensing; Linear Accelerator Radiotherapy Systems; Maps; Measurement; Measures; Medical Imaging; Medicine; Methods; Monte Carlo Method; Movement; Nature; Patients; Performance; Phase; Physics; Process; Production; Publications; Quality Control; Radiation; Radiation Oncology; Radiation therapy; Records; Reporting; Research; Resolution; Safety; Site; Skin; Software Tools; Specific qualifier value; Surface; Surveys; System; Technology; Testing; Time; Tissues; Translating; Water; Work; base; college; cost; design; dosimetry; feeding; imaging system; improved; in vivo; ionization; irradiation; light emission; new technology; oncology; optical imaging; prevent; programs; prototype; skin color; software development; time use; tool; treatment planning; whole body imaging

 DESCRIPTION (provided by applicant): For the first time, it is possible to directly visualize a radiation beam incident upon a patient's tissue in real time, using Cerenkov emission imaging. This imaging could transform the ease for verifying delivery in radiation oncology, and allow on the fly reporting, recording and correction of replanning needs or delivery errors. In a field wher there is an incredibly high number of new technologies for delivery, the verification of delivery and recording of adverse incidents will become more and more critical and yet the ease of implementation must be improved. A recent discovery that gated intensified imaging allows video-rate passive detection of Cherenkov emission during radiation therapy with the room lights on, and so the delivery process is unaffected by the imaging system. This opens up a new important paradigm in radiation oncology verification. This work has been invented and patented at Dartmouth, and DoseOptics LLC is a company spin-off of this research program, with the goal to advance video-rate Cerenkov imaging as a dose delivery visualization & verification tool. The feasibility of the system has been proven through the technological refinement and pilot clinical trial at Dartmouth. The next phase of this work involves the DoseOptics prototype development as a C-Dose OnBoard verification tool for imaging patients during treatment from the view of the LINAC gantry. The system will be developed with a unique proprietary moderate cost design, which will then be tested in phantoms and with patient treatment plans delivered to water tanks. The system will have capabilities for video-rate capture of IMRT/VMAT data, tracking MLC movements in real time, and allowing analysis of treatment plans on a beam to beam basis. The competing technologies using ionization chambers or diode arrays are low resolution devices with limitations that they cannot eventually translate to direct on-patient imaging. The work carried out in the company is augmented by a plan to evaluate the system in Clinical Physics at Dartmouth, and be further evaluated at Stanford and UPenn. The technology patent protected as developed by this group, and for this start up, the team of developers includes a substantial number of experts in Cerenkov imaging, medical physics and new venture creation.

 描述(由申请人提供)：首次使用切伦科夫发射成像技术，可以实时直接可视化入射到患者组织上的辐射束。这种成像可以改变放射肿瘤学中验证交付的简便性，并允许动态报告、记录和纠正重新计划需求或交付错误。在一个交付新技术数量高得令人难以置信的领域，核查交付和记录不良事件将变得越来越重要，但必须提高执行的简易性。最近的一项发现，门控增强成像允许在房间灯光打开的情况下对放射治疗期间的切伦科夫辐射进行视频率被动检测，因此传输过程不受成像系统的影响。这为放射肿瘤学验证开辟了一种新的重要范式。这项工作已经在达特茅斯发明并获得了专利，DoseOptics LLC是该研究计划的公司衍生产品，目标是推动视频率Cerenkov成像作为剂量传递可视化和验证工具的发展。该系统的可行性已经通过达特茅斯的技术改进和试点临床试验得到了证明。这项工作的下一阶段涉及DoseOptics原型的开发，作为一种C剂量机载验证工具，用于从直线加速器机架的角度对治疗期间的患者进行成像。该系统将以独特的专有中等成本设计进行开发，然后将在幻影中进行测试，并将患者治疗计划发送到水箱。该系统将具有以视频速率捕获IMRT/VMAT数据的能力，实时跟踪MLC运动，并允许在逐个射束的基础上分析治疗计划。使用电离室或二极管阵列的竞争技术是低分辨率设备，具有局限性，最终无法转化为直接在患者身上进行成像。该公司开展的工作还包括在达特茅斯大学评估临床物理学系统的计划，并在斯坦福大学和宾夕法尼亚大学进一步评估该系统。受保护的技术专利由这个团队开发，对于这个初创企业，开发团队包括大量切伦科夫成像、医学物理和新企业创建方面的专家。