Video Rate optical verification tool for radiotherapy treatment plans

摘要 这是第一次能够直接可视化辐射束击中患者的组织或高分辨率 使用切伦科夫发射成像对水箱体模中的辐射传递进行成像。这允许 有机会在高分辨率下进行治疗前验证，并在测试体模之前进行真实的时间视频 交付给患者。放射疗法具有多种多样且日益复杂的递送系统，然而， 对医学物理学支助小组来说，对这些数据进行独立核查仍然是一项时间密集的挑战。 通常，验证仅真正用于最复杂的立体定向情况，其中高分辨率和 较小的光束尺寸是关键的。然而，这些正是目前用于验证该计划的工具所处的情况。 限制.为了不使系统负担过重，核查工具必须变得更好、更快和更准确。的 使用电离室或二极管阵列的竞争技术， 设备或低时间分辨率，这取决于配置。最近发现门控强化了 成像允许在放射治疗期间对切伦科夫发射进行视频速率检测，这开辟了一个新的 放射肿瘤学的重要范例。这项工作已经在达特茅斯发明并获得专利， 独家授权给DoseOptics LLC，这是一个研究项目的衍生产品，其目标是提高视频速率 切伦科夫成像作为剂量传递成像工具。在第一阶段1应用程序中开发的alpha原型 表明，一个低成本的系统可以原型IMRT/VMAT验证水箱成像，称为C- 确认。C-Verify系统将进一步生产成少数Beta单元，这些单元将在合作伙伴处进行测试 学术医疗中心，以及在MRI引导的放射治疗单位。该系统将实现视频速率 以亚毫米空间分辨率捕获IMRT/VMAT数据，并将与外部门户网站相结合 用于治疗的全3D体积视频速率验证的成像设备数据。专业化整合 解剖和运动身体幻影将完善测试产品线，这迫切需要的进步， 放疗该软件工具将允许非专家用户直接与治疗计划进行比较，使用 预期用于验证的标准伽马分析惯例。在公司开展的工作是 通过在达特茅斯临床物理学中评估该系统的计划进行增强，并在 斯坦福大学，宾夕法尼亚大学和华盛顿大学。该集团开发的技术专利受到保护，对于这家初创企业， 开发团队包括切伦科夫成像、医学物理和新技术领域的大量专家， 创业

Abstract For the first time, it is possible to directly visualize a radiation beam hitting a patient's tissue or high resolution imaging of radiation delivery in water tank phantoms, using Cherenkov emission imaging. This allows the opportunity to do pre-treatment verification at high resolution, with real time video of a test phantom, prior to delivery to the patient. Radiotherapy has a diverse and increasingly complex number of delivery systems, yet independent verification of these remains a time-intensive challenge for the medical physics support team. Typically verification is only really utilized for the most complex stereotactic cases, where high resolution and small beam sizes are critical. Yet these are exactly the situations where current tools to verify the plan have limits. In order to not to overburden the system, verification tools must get better, faster and more accurate. The competing technologies using ionization chambers or diode arrays which largely are low spatial resolution devices or low temporal resolution, depending upon the configuration. A recent discovery that gated intensified imaging allows video-rate detection of Cherenkov emission during radiation therapy has opened up a new important paradigm in radiation oncology. This work has been invented and patented at Dartmouth, and exclusively licensed to DoseOptics LLC, a spin-off of this research program with the goal to advance video-rate Cerenkov imaging as a dose delivery imaging tool. The alpha prototype developed in this first phase 1 application showed that a low cost system could be prototyped for IMRT/VMAT verification in water tank imaging, called C- Verify. The C-Verify system will be further produced into a handful of Beta units which will be tested at partner academic medical center, as well as within an MRI-guided radiotherapy unit. The system will achieve video-rate capture of IMRT/VMAT data at sub-millimeter spatial resolution, and will be combined with external portal imaging device data for full 3D volumetric video rate validation of treatments. The integration of specialized anatomic and motion body phantoms will round out the test product lines for this badly needed advance in radiotherapy. The software tool will allow the non-expert user to directly compare to the treatment plan, using standard gamma analysis conventions expected for verification. The work carried out in the company is augmented by a plan to evaluate the system in Clinical Physics at Dartmouth, and be further evaluated at Stanford, UPenn and WashU. The technology patent protected as developed by this group, and for this start up, the team of developers includes a substantial number of experts in Cerenkov imaging, medical physics and new venture creation.