Video Rate optical verification tool for radiotherapy treatment plans

放射治疗计划的视频速率光学验证工具

• 批准号: 9253809
• 负责人: William Ware
• 金额: $ 101.64万
• 依托单位: DOSEOPTICS, LLC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9253809
• 关键词: Academic Medical Centers; Adoption; Air; Anatomy; Back; Breast; Clinical; Complex; Data; Detection; Development; Devices; Dose; Electrons; Ensure; Evaluation; Goals; Hybrids; Image; Imaging Device; Intensity-Modulated Radiotherapy; Lateral; Legal patent; Licensing; Magnetic Resonance Imaging; Maps; Marketing; Medical; Medical Imaging; Methods; Motion; Optics; Patients; Performance; Phase; Physics; Publishing; Radiation; Radiation Oncology; Radiation therapy; Research; Resolution; Site; Skin; Software Tools; System; Technology; Testing; Time; Tissues; Validation; Water; Work; abstracting; base; beam dynamics; breast imaging; cost; data acquisition; feeding; flexibility; human tissue; imaging system; innovation; ionization; irradiation; millimeter; programs; prototype; symposium; temporal measurement; tool; treatment planning; visual feedback; visual information

Abstract For the first time, it is possible to directly visualize a radiation beam hitting a patient's tissue or high resolution imaging of radiation delivery in water tank phantoms, using Cherenkov emission imaging. This allows the opportunity to do pre-treatment verification at high resolution, with real time video of a test phantom, prior to delivery to the patient. Radiotherapy has a diverse and increasingly complex number of delivery systems, yet independent verification of these remains a time-intensive challenge for the medical physics support team. Typically verification is only really utilized for the most complex stereotactic cases, where high resolution and small beam sizes are critical. Yet these are exactly the situations where current tools to verify the plan have limits. In order to not to overburden the system, verification tools must get better, faster and more accurate. The competing technologies using ionization chambers or diode arrays which largely are low spatial resolution devices or low temporal resolution, depending upon the configuration. A recent discovery that gated intensified imaging allows video-rate detection of Cherenkov emission during radiation therapy has opened up a new important paradigm in radiation oncology. This work has been invented and patented at Dartmouth, and exclusively licensed to DoseOptics LLC, a spin-off of this research program with the goal to advance video-rate Cerenkov imaging as a dose delivery imaging tool. The alpha prototype developed in this first phase 1 application showed that a low cost system could be prototyped for IMRT/VMAT verification in water tank imaging, called C- Verify. The C-Verify system will be further produced into a handful of Beta units which will be tested at partner academic medical center, as well as within an MRI-guided radiotherapy unit. The system will achieve video-rate capture of IMRT/VMAT data at sub-millimeter spatial resolution, and will be combined with external portal imaging device data for full 3D volumetric video rate validation of treatments. The integration of specialized anatomic and motion body phantoms will round out the test product lines for this badly needed advance in radiotherapy. The software tool will allow the non-expert user to directly compare to the treatment plan, using standard gamma analysis conventions expected for verification. The work carried out in the company is augmented by a plan to evaluate the system in Clinical Physics at Dartmouth, and be further evaluated at Stanford, UPenn and WashU. The technology patent protected as developed by this group, and for this start up, the team of developers includes a substantial number of experts in Cerenkov imaging, medical physics and new venture creation.

抽象的 第一次可以直接可视化照射患者组织的辐射束或高分辨率 使用切伦科夫发射成像对水箱模型中的辐射传输进行成像。这允许 有机会在治疗前通过测试体模的实时视频以高分辨率进行治疗前验证 交付给患者。放射治疗具有多样化且数量日益复杂的传输系统，但 对于医学物理支持团队来说，对这些进行独立验证仍然是一项耗时的挑战。 通常，验证仅真正用于最复杂的立体定向情况，其中高分辨率和 小光束尺寸至关重要。然而，这些正是当前验证计划的工具所面临的情况。 限制。为了不使系统负担过重，验证工具必须变得更好、更快、更准确。这 使用电离室或二极管阵列的竞争技术大多空间分辨率较低 设备或低时间分辨率，具体取决于配置。最近的一项发现加强了门控 成像允许在放射治疗过程中以视频速率检测切伦科夫发射开辟了新的途径 放射肿瘤学的重要范例。这项工作已在达特茅斯学院发明并获得专利，并且 独家授权给 DoseOptics LLC，该研究项目的一个衍生项目，旨在提高视频速率 切伦科夫成像作为剂量输送成像工具。在第一个第一阶段应用中开发的 alpha 原型 表明可以制作一个低成本系统原型，用于水箱成像中的 IMRT/VMAT 验证，称为 C- 核实。 C-Verify 系统将进一步生产为少数 Beta 单元，并在合作伙伴处进行测试 学术医疗中心以及 MRI 引导放射治疗单位内。系统将达到视频速率 以亚毫米空间分辨率捕获 IMRT/VMAT 数据，并将与外部门户相结合 用于治疗的全 3D 体积视频速率验证的成像设备数据。专业化的整合 解剖学和运动人体模型将完善测试产品线，以实现这一急需的进步 放射治疗。该软件工具将允许非专家用户直接与治疗计划进行比较，使用 预期用于验证的标准伽玛分析约定。在公司进行的工作是 通过评估达特茅斯临床物理学系统的计划进行了增强，并在 斯坦福大学、宾夕法尼亚大学和华盛顿大学。该团队开发的技术受到专利保护，对于此次启动， 开发团队包括切伦科夫成像、医学物理和新领域的大量专家 创业创造。