Video Rate optical verification tool for radiotherapy treatment plans

摘要 这是第一次，可以直接看到辐射束击中患者的组织或高分辨率 使用切伦科夫发射成像对水箱模体中的辐射传输进行成像。这允许 利用测试模型的实时视频以高分辨率进行治疗前验证的机会，在 送到病人手中。放射治疗有各种各样和越来越复杂的递送系统，但 对医学物理支持团队来说，对这些进行独立验证仍然是一项耗时的挑战。 通常，验证仅真正用于最复杂的立体定向情况，其中高分辨率和 小的光束尺寸至关重要。然而，这些正是目前用于验证计划的工具所具有的情况 极限。为了不让系统负担过重，验证工具必须变得更好、更快、更准确。这个 使用电离室或二极管阵列的竞争技术，这些技术大多是低空间分辨率 设备或低时间分辨率，具体取决于配置。最近的一项发现，GATE加强了 成像允许视频率检测切伦科夫放射治疗期间的发射开辟了一种新的 放射肿瘤学中的重要范例。这项工作已经在达特茅斯发明并获得了专利，而且 独家授权给DoseOptics LLC，这是该研究计划的副产品，目标是提高视频率 切伦科夫成像作为一种剂量传递成像工具。在这个第一阶段1应用程序中开发的阿尔法原型 显示了一种低成本的系统原型可以用于水箱成像中的IMRT/VMAT验证，称为C- 核实一下。C-Verify系统将进一步生产成几个Beta单元，将在合作伙伴处进行测试 学术医疗中心，以及核磁共振引导的放射治疗单元。该系统将达到视频率 以亚毫米空间分辨率捕获IMRT/VMAT数据，并将与外部门户相结合 用于治疗的全3D体积视频率验证的成像设备数据。专业技术的整合 解剖学和运动体幻影将完善这一亟需进步的测试产品线 放射治疗。该软件工具将允许非专家用户直接与治疗计划进行比较，使用 预计将进行验证的标准伽马分析约定。该公司开展的工作是 通过在达特茅斯的临床物理学中评估该系统的计划，并在 斯坦福大学、宾夕法尼亚大学和华盛顿大学。这个团队开发的受保护的技术专利，对于这个初创企业来说， 开发团队包括大量切伦科夫成像、医学物理和新技术方面的专家 风险创造。

Abstract For the first time, it is possible to directly visualize a radiation beam hitting a patient's tissue or high resolution imaging of radiation delivery in water tank phantoms, using Cherenkov emission imaging. This allows the opportunity to do pre-treatment verification at high resolution, with real time video of a test phantom, prior to delivery to the patient. Radiotherapy has a diverse and increasingly complex number of delivery systems, yet independent verification of these remains a time-intensive challenge for the medical physics support team. Typically verification is only really utilized for the most complex stereotactic cases, where high resolution and small beam sizes are critical. Yet these are exactly the situations where current tools to verify the plan have limits. In order to not to overburden the system, verification tools must get better, faster and more accurate. The competing technologies using ionization chambers or diode arrays which largely are low spatial resolution devices or low temporal resolution, depending upon the configuration. A recent discovery that gated intensified imaging allows video-rate detection of Cherenkov emission during radiation therapy has opened up a new important paradigm in radiation oncology. This work has been invented and patented at Dartmouth, and exclusively licensed to DoseOptics LLC, a spin-off of this research program with the goal to advance video-rate Cerenkov imaging as a dose delivery imaging tool. The alpha prototype developed in this first phase 1 application showed that a low cost system could be prototyped for IMRT/VMAT verification in water tank imaging, called C- Verify. The C-Verify system will be further produced into a handful of Beta units which will be tested at partner academic medical center, as well as within an MRI-guided radiotherapy unit. The system will achieve video-rate capture of IMRT/VMAT data at sub-millimeter spatial resolution, and will be combined with external portal imaging device data for full 3D volumetric video rate validation of treatments. The integration of specialized anatomic and motion body phantoms will round out the test product lines for this badly needed advance in radiotherapy. The software tool will allow the non-expert user to directly compare to the treatment plan, using standard gamma analysis conventions expected for verification. The work carried out in the company is augmented by a plan to evaluate the system in Clinical Physics at Dartmouth, and be further evaluated at Stanford, UPenn and WashU. The technology patent protected as developed by this group, and for this start up, the team of developers includes a substantial number of experts in Cerenkov imaging, medical physics and new venture creation.