Video Rate optical verification tool for radiotherapy treatment plans

放射治疗计划的视频速率光学验证工具

• 批准号: 9253809
• 负责人: William Ware
• 金额: $ 101.64万
• 依托单位: DOSEOPTICS, LLC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9253809
• 关键词: Academic Medical Centers; Adoption; Air; Anatomy; Back; Breast; Clinical; Complex; Data; Detection; Development; Devices; Dose; Electrons; Ensure; Evaluation; Goals; Hybrids; Image; Imaging Device; Intensity-Modulated Radiotherapy; Lateral; Legal patent; Licensing; Magnetic Resonance Imaging; Maps; Marketing; Medical; Medical Imaging; Methods; Motion; Optics; Patients; Performance; Phase; Physics; Publishing; Radiation; Radiation Oncology; Radiation therapy; Research; Resolution; Site; Skin; Software Tools; System; Technology; Testing; Time; Tissues; Validation; Water; Work; abstracting; base; beam dynamics; breast imaging; cost; data acquisition; feeding; flexibility; human tissue; imaging system; innovation; ionization; irradiation; millimeter; programs; prototype; symposium; temporal measurement; tool; treatment planning; visual feedback; visual information

Abstract For the first time, it is possible to directly visualize a radiation beam hitting a patient's tissue or high resolution imaging of radiation delivery in water tank phantoms, using Cherenkov emission imaging. This allows the opportunity to do pre-treatment verification at high resolution, with real time video of a test phantom, prior to delivery to the patient. Radiotherapy has a diverse and increasingly complex number of delivery systems, yet independent verification of these remains a time-intensive challenge for the medical physics support team. Typically verification is only really utilized for the most complex stereotactic cases, where high resolution and small beam sizes are critical. Yet these are exactly the situations where current tools to verify the plan have limits. In order to not to overburden the system, verification tools must get better, faster and more accurate. The competing technologies using ionization chambers or diode arrays which largely are low spatial resolution devices or low temporal resolution, depending upon the configuration. A recent discovery that gated intensified imaging allows video-rate detection of Cherenkov emission during radiation therapy has opened up a new important paradigm in radiation oncology. This work has been invented and patented at Dartmouth, and exclusively licensed to DoseOptics LLC, a spin-off of this research program with the goal to advance video-rate Cerenkov imaging as a dose delivery imaging tool. The alpha prototype developed in this first phase 1 application showed that a low cost system could be prototyped for IMRT/VMAT verification in water tank imaging, called C- Verify. The C-Verify system will be further produced into a handful of Beta units which will be tested at partner academic medical center, as well as within an MRI-guided radiotherapy unit. The system will achieve video-rate capture of IMRT/VMAT data at sub-millimeter spatial resolution, and will be combined with external portal imaging device data for full 3D volumetric video rate validation of treatments. The integration of specialized anatomic and motion body phantoms will round out the test product lines for this badly needed advance in radiotherapy. The software tool will allow the non-expert user to directly compare to the treatment plan, using standard gamma analysis conventions expected for verification. The work carried out in the company is augmented by a plan to evaluate the system in Clinical Physics at Dartmouth, and be further evaluated at Stanford, UPenn and WashU. The technology patent protected as developed by this group, and for this start up, the team of developers includes a substantial number of experts in Cerenkov imaging, medical physics and new venture creation.

抽象的 首次可以直接可视化辐射梁击中患者的组织或高分辨率 使用Cherenkov发射成像，在水箱幻像中辐射输送的成像。这允许 在高分辨率上进行预处理验证的机会，并在测试幻影的实时视频中进行 交付给患者。放射疗法具有多样化且日益复杂的输送系统 对这些医学物理支持团队的独立验证仍然是耗时的挑战。 通常，验证仅用于最复杂的立体定向案例，在高分辨率和高分辨率的情况下 小型光束尺寸至关重要。然而，这些正是当前验证计划已有的工具的情况 极限。为了不承担系统，验证工具必须变得更好，更快，更准确。这 使用电离室或二极管阵列的竞争技术主要是低空间分辨率 设备或低时间分辨率，具体取决于配置。最近的发现加剧了 成像允许在放射疗法期间的视频速率检测Cherenkov排放已打开新的 辐射肿瘤学的重要范式。这项工作已在达特茅斯发明和专利， 专门获得Doseoptics LLC的许可，这是该研究计划的衍生产品，其目标是提高视频速率 Cerenkov成像作为剂量输送成像工具。在第一阶段1应用中开发的alpha原型 表明，在水箱成像中，可以针对IMRT/VMAT验证进行低成本系统，称为C- 核实。 C验证系统将进一步生产到少数Beta单元中 学术医疗中心以及MRI引导放射疗法单元。该系统将达到视频速率 在亚毫米空间分辨率下捕获IMRT/VMAT数据，并将与外部门户结合 成像设备数据，用于完整3D体积视频速率验证处理。专业的集成 解剖和运动体幻象将为这一急需的进步而完整的测试产品线。 放疗。该软件工具将允许非专家用户直接与治疗计划进行比较 预期验证的标准伽马分析惯例。公司在公司中进行的工作是 由计划评估达特茅斯临床物理系统的计划的增强，并在 斯坦福大学，乌普和华盛顿。该小组开发的技术专利保护，为此， 开发人员团队包括大量Cerenkov成像，医学物理和新专家 冒险创造。