Northeast Node of the National Drug Abuse Clinical Trials Network

项目概要/摘要 我们建议建立一个新的NIDA临床试验网络节点--东北节点 横跨新罕布什尔州、佛蒙特州和缅因州的农村社区。此节点将基于 达特茅斯学院与几个大型供应商网络合作，涵盖400多名成人和/或 青少年一般医疗保健合作伙伴，一系列成瘾专业计划，和一个国家行为 健康管理护理合作伙伴。达特茅斯是这个节点的理想家园，因为它也是NIDA的家园- 资助的技术和行为健康中心（CTBH），一个P30“卓越中心”，使用科学 为基于技术（网络、移动的）的开发、评估和战略实施提供信息 针对物质使用障碍（SUD）和相关问题（包括艾滋病毒风险行为和 精神病合并症）。CTBH由丽莎马施博士领导，她也将担任主要研究者 在提议的CTN节点上。我们的团队通过提高质量、实现速度和 科学研究的影响集中在技术应用于SUD和行为健康治疗。 我们的团队在SUD干预开发的各个阶段都有专业知识，从可行性，可接受性， 功效、功效-效果、有效性（包括多中心有效性试验）、成本-效果和 在许多情况下的实施研究，包括成瘾和心理健康专业计划，医疗 专业计划，医院，学校，刑事司法机构和初级保健。这项工作包括 关于将可持续发展的干预措施纳入农村保健系统的开创性研究。本作品已 在广泛的人群中进行，包括慢性吸毒者、吸烟者、退伍军人、慢性疼痛 患者、HIV高危人群以及同时患有SUD和精神疾病的人群。我们集团 特别是在青年研究方面的专门知识，从筛查和评估，预防，治疗， 康复支持和青少年护理协调-包括几项重点研究， 青少年中的大麻使用和处方类阿片使用障碍。该提案的目的是：（1）扩大 通过启动CTN的东北节点，将NIDA CTN扩展到农村地区的新州， 扩大我们与初级保健和其他社区治疗合作伙伴的合作， 实施针对SUD的及时和重要的试验，（2）支持和发展富有成效的研究议程 特别关注集中利用基于技术的工具和/或具有优先重点的CTN试验 关于青年-在东北节点内以及通过在国家CTN内发挥领导和咨询作用 社区，以及（3）开发和支持基础设施，以增强协同作用并支持双向 CTBH和CTN之间的知识和资源共享。这些活动将为关键的科学研究提供信息， 关于农村卫生保健系统中与物质使用有关的需求和优先事项的发现和见解 以及各种社区系统中基于技术的干预措施的有效性。

Project Summary/Abstract We propose to establish a new Node of the NIDA Clinical Trials Network (CTN) -- the Northeast Node spanning the rural communities of New Hampshire, Vermont, and Maine. This Node will be based out of Dartmouth College in collaboration with several large provider networks spanning over 400 adult and/or adolescent general medical care partners, an array of addiction-specialty programs, and a national behavioral health managed care partner. Dartmouth is an ideal home for this Node, as it also the home of the NIDA- funded Center for Technology and Behavioral Health (CTBH), a P30 “Center of Excellence” that uses science to inform the development, evaluation, and strategic implementation of technology (web, mobile)-based therapeutic tools targeting substance use disorders (SUDs) and related issues (including HIV risk behavior and psychiatric comorbidities). CTBH is led by Dr. Lisa Marsch, who will also serve as the Principal Investigator on the proposed CTN node. Our team has led the field by enhancing the quality, pace of achievement, and impact of scientific research focused on the application of technology to SUD and behavioral health treatment. Our team has expertise in all stages of SUD intervention development, ranging from feasibility, acceptability, efficacy, efficacy-effectiveness, effectiveness (including multi-site effectiveness trials), cost-effectiveness, and implementation research in many contexts, including addiction and mental health specialty programs, medical specialty programs, hospitals, schools, criminal justice settings, and primary care. This work has included seminal research on the integration of SUD interventions into rural health care systems. This work has been conducted with a wide array of populations including chronic drug users, smokers, veterans, chronic pain patients, persons at risk for HIV, and persons with co-occurring SUDs and mental illness. Our group has particular expertise in research with youth, ranging from screening and assessment, prevention, treatment, recovery support, and care coordination for adolescents -- including several lines of research focused on cannabis use and prescription opioid use disorders among youth. The Aims of this proposal are to (1) Expand the NIDA CTN to new states in rural regions by launching the Northeast Node of the CTN and thereby expanding our collaborations with primary care and other community treatment partners in identifying and implementing timely and significant trials targeting SUDs, (2) Support and grow a productive research agenda with a particular focus on CTN trials that centrally leverage technology-based tools and/or have a priority focus on youth – both within the Northeast Node and via leadership and advisory roles within the national CTN community, and (3) Develop and support an infrastructure to enhance synergy and support bidirectional sharing of knowledge and resources between CTBH and the CTN. These activities will inform key scientific discoveries and insights regarding the substance use-related needs and priorities in rural health care systems as well as the effectiveness of technology-based interventions in a diverse array of community systems.