Institute for Clinical and Translational Science

临床与转化科学研究所

• 批准号: 9903508
• 负责人: DAN M COOPER
• 金额: $ 359.57万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9903508
• 关键词: Acceleration; Address; Advisory Committees; Alzheimer' s Disease; Applied Research; Area; Asian Americans; Award; Basic Science; Bioinformatics; Biological Markers; Biomedical Research; Biotechnology; California; Cardiopulmonary; Certification; Child; Child Care; Child Health; Chronic Disease; Clinical; Clinical Data; Clinical Informatics; Clinical Research; Clinical Sciences; Clinical Trials; Clostridium perfringens epsilon toxin; Collaborations; Communities; Complex; Consultations; Data; Development; Disease; Elderly; Ensure; Environment; Evaluation; Exercise; Exercise stress test; Faculty; Fellowship; Flow Cytometry; Funding; Glossary; Goals; Grant; Health; Health system; Healthcare; Homelessness; Human; Human Resources; Improve Access; Incubators; Industry; Industry Collaboration; Informatics; Infrastructure; Injury; Institutes; Interdisciplinary Study; Laboratories; Language; Latino; Learning; Link; Longevity; Medicine; Methods; Military Personnel; Minority-Serving Institution; Mission; Modernization; Molecular; Movement; Pathway interactions; Patient Outcomes Assessments; Patients; Phase; Physical Fitness; Physical activity; Population Heterogeneity; Positioning Attribute; Process; Program Sustainability; Recording of previous events; Registries; Rehabilitation therapy; Research; Research Design; Research Ethics; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Robotics; Safety; Schools; Science; Terminology; Testing; Training; Training Activity; Training Programs; Transducers; Translational Research; Translations; Underserved Population; Universities; Veterans; Work; Workforce Development; base; biobank; biomedical informatics; career; catalyst; clinical care; cohesion; cohort; design; experience; fitness test; health care availability; health record; improved; innovation; learning progression; named group; novel; novel marker; novel strategies; outreach program; population health; programs; recruit; skills; social media; stem; symposium; systems research; tool; training opportunity; virtual laboratory

Since 2010, the Institute for Clinical and Translational Science (ICTS) at UCI, a young public university that vigorously supports translational science, has transformed clinical research across our healthcare enterprise. We did so by breaking down traditional academic silos at our university, building robust partnerships in our diverse community, and engendering innovative projects throughout the CTSA Network. Strategies for the next phase of ICTS address significant challenges and unmet needs in healthcare regionally and nationally. Our plans, built on a strong record of accomplishment, include: 1. Workforce Development. We will launch a range of training opportunities that highlight diversity and accessibility, and create pathways to excellence and certification for all ICTS faculty, staff, partners, and trainees. Informatics and quality improvement through continuous learning will be embedded in all training activities. 2. Collaboration and engagement. We will implement training in team science, providing skills to incorporate the perspectives of key stakeholders in clinical research planning. Working with the NCATS Trial Innovation Network, we pilot-tested a Community Engagement Studio training module and will disseminate the program across the network. 3. Integration. To improve the reach of our clinical trials, we will activate UCI teams experienced in recruiting special populations, such as the homeless, babies and children, veterans, the elderly, and the Latino and Asian American communities in our region. Aided by a State of California $30 million infrastructure grant to improve access to health care for underserved children, we engaged national experts in learning health systems research (LHS). We will launch LHS projects on a) improving care for children with chronic diseases and complex conditions, and b) mitigating abuse in the elderly. 4. Methods and processes. We coalesced statistical personnel from across the university and will provide easily accessible consultation for both routine and complex study designs. Stemming from our funded CTSA collaboration innovation award, we will pilot test machine-language analytics for flow cytometry in clinical research and disseminate these approaches across the network. Building on UCI expertise, we will use the Optional Functions to: a) accelerate the use of robotics in rehabilitation for a wide range of diseases and injuries, and b) harness the unrealized potential of school-based physical fitness testing to advance health across the lifespan. 5. Informatics. Our informatics leaders will build research and training programs for a new Clinical Informatics Fellowship and develop clinical research tools for our recently deployed Epic EHR. 6. Diversity. In concert with UCI’s commitment to inclusion excellence, ICTS will build new pipeline programs to enhance learning, collaboration, and career opportunities in CTS for a diverse cohort of trainees. In summary, a major goal of our 3rd funding cycle is to partner with the 3.5 million people in our engaged and diverse communities. We will be a laboratory for translational science, integrating data gathering and evaluation to “develop, demonstrate, and disseminate” novel research tools across the network.

自2010年以来，UCI的临床和翻译科学研究所(ICTS)是一所年轻的公立大学， 大力支持翻译科学，改变了我们整个医疗保健企业的临床研究。 为此，我们打破了我们大学的传统学术竖井，在我们的 多样化的社区，并在整个CTSA网络中产生创新项目。下一步的战略 ICTS阶段解决了区域和国家医疗保健方面的重大挑战和未得到满足的需求。我们的 建立在良好业绩记录基础上的计划包括：1.员工队伍发展。我们将推出一项 一系列突出多样性和可获得性的培训机会，并创造通往卓越和 为所有ICTS教职员工、合作伙伴和学员颁发证书。通过信息学和质量改进 持续学习将融入所有培训活动。2.协作和参与。我们会 实施团队科学培训，提供技能，将关键利益相关者的观点纳入 临床研究计划。与NCATS试验创新网络合作，我们对一个社区进行了试点测试 Engagement Studio培训模块，并将在网络上传播该计划。3.整合。至 为了扩大我们临床试验的覆盖面，我们将激活UCI在招募特殊人群方面经验丰富的团队， 如无家可归者，婴儿和儿童，退伍军人，老年人，以及拉丁裔和亚裔美国人 我们地区的社区。由加利福尼亚州提供3000万美元的基础设施赠款，以改善 为了解决服务不足儿童的医疗保健问题，我们聘请了学习卫生系统研究(LHS)的国家专家。 我们将启动LHS项目，以a)改善对患有慢性病和复杂疾病的儿童的护理， 以及b)减少对老年人的虐待。4.方法和流程。我们把统计人员从 并将为常规和复杂的学习提供方便的咨询 设计。根据我们资助的CTSA协作创新奖，我们将试验机器语言 在临床研究中对流式细胞术进行分析，并在网络中传播这些方法。建房 根据UCI的专业知识，我们将使用可选功能：a)加快机器人在康复中的使用 广泛的疾病和伤害，以及b)利用尚未实现的学校体育健身潜力 测试以提高寿命的健康。5.信息学。我们的信息学领导者将建立研究和 为新的临床信息学联谊会提供培训计划，并为我们最近的临床研究开发工具 部署了史诗EHR。6.多样性。本着UCI对包容性卓越的承诺，ICTS将建立 新的流水线计划，为不同的人群提供CTS的学习、协作和职业机会 实习生。总而言之，我们第三个资金周期的主要目标是与我们的350万人合作 参与式和多样化的社区。我们将成为翻译科学的实验室，整合数据收集 以及评估，以在整个网络中“开发、演示和传播”新的研究工具。