Enrichment Program Supplement

糖尿病是造成患者痛苦和社会成本的巨大且不断增加的负担，其影响 在少数群体和农村资源匮乏的社区中，这种疾病的发病率不成比例。在……里面 特别是，阿拉巴马黑带和密西西比三角洲是世界上糖尿病和肥胖率最高的地区 美国。需要针对农村人口进行研究，这些人口的特点是 少数族裔和较低的社会经济地位是更好地理解健康差距的基础所迫切需要的 并确定糖尿病治疗和预防的有效干预措施。 通过这次修订申请，UAB糖尿病研究中心(DRC)再次致力于改善我们的中心 我们南方腹地糖尿病患者的健康。为了扩大我们的科学研究范围，我们将建立一个 阿拉巴马州黑带县和密西西比河三角洲农村初级保健临床网络的研究 将为刚果民主共和国及其成员提供伙伴关系机会和基础设施的资源 在最有需要的患者中进行翻译和临床研究。我们的具体目标是： 目标1：在阿拉巴马州农村黑带地区建立糖尿病初级护理联盟。建房 根据正在进行的项目，我们将在阿拉巴马州农村建立初级保健诊所网络，并最终扩大 密西西比三角洲也是如此。该联盟将以可持续的伙伴关系、社区的参与为特色 卫生工作者，以及用于与初级保健诊所人员通信的远程保健系统，教育， 与患者进行消息传递，以及适应病历系统的数据捕获。 目标2：将初级保健联盟和临床网络整合为刚果民主共和国的研究资源。 临床网络将由干预和翻译核心来促进，资源将是可访问的 致我们刚果民主共和国的所有研究人员以及我们合作中心和学术机构的其他人。其他DRC 将对核心进行调整，以促进利用这一资源进行有效的假设检验。 目标3：开展创新生活方式计划(远程医疗+社区健康)的试点研究 工作人员)使用和不使用二甲双胍预防糖尿病。这项试点试验旨在巩固和 改进初级保健联盟内的操作，并为更大规模的随机试验开发数据 评估一种新的、可持续的糖尿病预防方法，包括创新的生活方式 干预联合二甲双胍治疗。 目前的修订申请强调了刚果民主共和国对以下伙伴关系和研究的承诺 旨在改善我们社区糖尿病和心脏代谢性疾病患者的健康 特别强调农村社区的健康差距。初级保健联盟被设计为一个 为研究慢性疾病差异和发展的机制提供了强大的资源 干预措施在这些高危人群中独一无二有效。

Diabetes is responsible for a huge and growing burden of patient suffering and social costs, and the impact of this disease is shared disproportionately by minorities and in rural resource-challenged communities. In particular, the Alabama Black Belt and the Mississippi delta have the highest rates of diabetes and obesity in the United States. The need for research targeted to rural populations characterized by a heavy preponderance of minorities and low socioeconomic status is acutely needed to better understand the basis for health disparities and to identify effective interventions for diabetes treatment and prevention. With this revision application, the UAB Diabetes Research Center (DRC) re-dedicates our center to improving the health of our patients with diabetes in the Deep South. To extend our scientific reach, we will establish a primary care clinical network in rural Black Belt counties of Alabama and in the Mississippi delta as a research resource that will provide the DRC and its members with opportunities for partnership and the infrastructure to conduct translational and clinical research in those patients with the greatest need. Our specific aims are: Aim 1: Establish a Diabetes Primary Care Coalition in the rural Black Belt region of Alabama. Building upon ongoing projects, we will establish a network of primary care clinics in rural Alabama and eventually expand to the Mississippi delta as well. The coalition will feature sustainable partnerships, engagement of community health workers, and a telehealth system for communication with primary care clinic personnel, education, messaging with patients, and data capture adapted to medical records systems. Aim 2: Integrate the Primary Care Coalition and clinical network as a research resource in the DRC. The clinical network will be facilitated by the Interventions & Translation Core, and the resource will be accessible to all investigators in our DRC as well as others in our partnering centers and academic institutions. Other DRC cores will be adapted to facilitate effective hypothesis testing using this resource. Aim 3: Conduct a pilot study of an innovative lifestyle program (telehealth + community health workers) with and without metformin for diabetes prevention. This pilot trial is intended to consolidate and refine operations within the primary care coalition, and to develop data for a larger scale randomized trial evaluating a novel and sustainable approach for diabetes prevention that involves an innovative lifestyle intervention combined with metformin. The current revision application underscores the commitment of the DRC to partnerships and research that is directed at improving health in patients with diabetes and cardiometabolic disease in our communities with a particular emphasis on health disparities in rural communities. The primary care coalition is designed as a powerful resource for the study of mechanisms responsible for chronic disease disparities and developing interventions uniquely effective in these high-risk populations.