Monochromatic 222 nm UV light: Development of a safe, cost-effective technology for the efficient reduction of bacterial and viral infection and transmission

单色 222 nm 紫外线：开发安全、经济高效的技术，有效减少细菌和病毒的感染和传播

• 批准号: 9899924
• 负责人: DAVID JONATHAN BRENNER
• 金额: $ 49.64万
• 依托单位: EDEN PARK ILLUMINATION, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-15 至 2021-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9899924
• 关键词: Address; Air; Anti-Bacterial Agents; Area; Bacteria; Bacterial Infections; Biological; Cells; Data; Development; Devices; Dose; Drug resistance; Exposure to; Eye; Film; Generations; Germicide; Goals; Health; Health Hazards; Hospitals; Human; Illinois; In Vitro; Industry; Influenza; Influenza A Virus, H1N1 Subtype; Knowledge; Life; Light; Lighting; Location; Measles; Mediating; Methodology; Microbe; Microbial Biofilms; Modality; Multiple Bacterial Drug Resistance; Mus; Operating Rooms; Operative Surgical Procedures; Outcome; Phase; Physics; Power Sources; Process; Property; Safety; Schools; Skin; Skin Cancer; Small Business Technology Transfer Research; Sterilization; Superbug; Surface; Surgical Wound Infection; Surgical incisions; Surgical wound; Technology; Testing; Tuberculosis; Ultraviolet Rays; Universities; Virus; Virus Diseases; Wound models; anti-viral efficacy; antimicrobial; base; carcinogenicity; commercial application; cost; cost effective; design; drug resistant bacteria; exposed human population; food preparation; hazard; health care economics; in vivo; infection rate; influenzavirus; methicillin resistant Staphylococcus aureus; next generation; open wound; phase 1 study; prevent; safety study; skin microbiome; transmission process; viral transmission; wound

Drug resistant bacteria such as MRSA, and airborne-transmitted microbes such as influenza and TB, present significant health issues, with major healthcare and economic consequences. UV light is a well-established highly-efficient anti-microbial modality, effective both against both bacteria and viruses. However it is not possible to use UV sterilization in scenarios where people are present because it is both carcinogenic and cataractogenic. Based on basic physics principles and supported by our Preliminary and Phase I Studies, far- UVC light (~222 nm generated from a KrCl excimer lamp) has all the anti-microbial advantages of conventional germicidal UV lamps, but without the corresponding human safety hazards. Thus the many demonstrated in-air anti-microbial applications of germicidal UV lamps, which cannot currently be applied when humans are present, can now be considered as potentially practical in the presence of humans. The market is twofold: Initially for hospitals, in operating rooms for irradiating above incisions during surgery to reduce surgical site infection rates. Secondly for public locations such as schools, hospitals, doctors offices, airports, airplanes and the food preparation industry, to reduce airborne transmission of viruses including influenza and measles, and bacteria such as TB. A key advantage is that UV bacterial killing is independent of drug resistance, so our approach addresses the ever-growing issue of “superbugs”. Neither higher (>230 nm) nor lower (<200 nm) wavelengths have the desired properties. Our products will be inexpensive, long-lived far-UVC excimer lamps, emitting at 222 nm and with minimal higher-wavelength emission. No such 222 nm lamp is currently available and, without a new technological breakthrough, appropriate LEDs are not practical in the relevant wavelength range below 230 nm. In Phase I we developed a high-intensity 222 nm excimer lamp with a lifetime of >5,000 h, and minimal emissions at higher wavelengths. In Phase II we will design, fabricate and test large area (>300 cm2) 222 nm excimer lamps with a further 5-fold intensity increase to >20 mW/cm2. Fabrication processes will be optimized to reduce costs and a matching filtered power supply developed. 222 nm light is safe for human exposure based on pure physics: 222 nm light cannot penetrate through the skin outer dead cell layer, nor the eye's surface tear film layer, nor into skin microbiome biofilms. This has been confirmed with our short-term safety studies, but we recognize the need for confirmatory long-term safety data. In Phase I we demonstrated that 222 nm light does not cause biological damage to the skin or eye, using relevant short-term in-vivo endpoints. In Phase II we will extend these in-vivo safety studies to prolonged (60 weeks) far-UVC exposures and long-term endpoints (skin cancer, skin microbiome, ocular damage). A conventional germicidal UV lamp designed for management of bacteria in open wounds has FDA 510(k) approval and will be the primary predicate device for our initial 510(k) application

耐药细菌，如耐甲氧西林金黄色葡萄球菌，以及空气传播的微生物，如流感和结核

项目成果

Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation.

• DOI: 10.3390/v14040684
• 发表时间: 2022-03-25
• 期刊: Viruses

No Evidence of Induced Skin Cancer or Other Skin Abnormalities after Long-Term (66 week) Chronic Exposure to 222-nm Far-UVC Radiation.

• DOI: 10.1111/php.13656
• 发表时间: 2023-01
• 期刊: PHOTOCHEMISTRY AND PHOTOBIOLOGY
• 影响因子: 3.3
• 作者: Welch, David;Kleiman, Norman J.;Arden, Peter C.;Kuryla, Christine L.;Buonanno, Manuela;Ponnaiya, Brian;Wu, Xuefeng;Brenner, David J.
• 通讯作者: Brenner, David J.