Novel Treatments for Ocular Surface Diseases
眼表疾病的新疗法
基本信息
- 批准号:9902473
- 负责人:
- 金额:$ 39.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdvanced DevelopmentAffectAnimalsAnti-Infective AgentsAnti-Inflammatory AgentsAutophagocytosisBenzalkonium ChlorideBindingBinding ProteinsBiological AssayCell Culture TechniquesClinicalCopperCorneaCustomDataDesiccationDevelopmentDiseaseDisease modelDrug FormulationsEnsureEnvironmentEnzymesEpithelialEpitheliumExposure toEye diseasesFamilyFilmFunctional disorderFutureG-Protein-Coupled ReceptorsGlaucomaHistidineHomeostasisHumanHumidityIL8 geneIn VitroInflammationInflammation MediatorsInflammatoryInterleukin-6Lacrimal gland structureLigandsMammalian CellMatrix MetalloproteinasesMeasuresMediatingMediator of activation proteinMetalsMethodsModelingMucositisNickelOralOsmolar ConcentrationOutcomePatientsPeptide HydrolasesPeptidesPharmaceutical PreparationsPhysiologicalProductionPropertyProteinsProtocols documentationPublishingQuality of lifeResearchSalivaStressSystemTestingTherapeuticTherapeutic EffectToxic effectToxicant exposureVisionVisualantimicrobialantimicrobial peptidebaseclinically relevantcorneal epitheliumcytokinedesignexperienceexperimental studyeye drynesshistatin 1histidine-rich proteinsimprovedin vivoin vivo Modelinnovationlacrimalmigrationmouse modelnovelnovel therapeuticsocular surfaceophthalmic drugpalliativereceptorscreeningsynthetic peptidetranslational modelwound healing
项目摘要
PROJECT DESCRIPTION/ABSTRACT
Dry eye disease (DED) and other ocular surface diseases (OSD) are common conditions that can reduce visual
function and quality of life. Commonly used ophthalmic preservatives can cause a toxic epitheliopathy that
results in OSD. The treatment of these diseases is primarily through the use of palliative measures. Great
opportunity exists to improve the quality of life of many patients by developing novel treatments. DED and OSD
are associated with significant dysfunction of corneal epithelia and inflammatory changes on the ocular surface.
Many of these changes are induced by hyperosmolarity, desiccation and inflammatory insults. Histatin is a family
of peptides found primarily in saliva and is known to have significant wound healing and anti-infective properties.
Little data exist on the mechanisms of action of histatin peptides, though some effects are thought to be
mediated through as yet unknown receptors. We have found that these peptides can reduce inflammatory
changes associated with exposures of toxic preservatives to the ocular surface and in experimental conditions
that mimic DED. We have also found a potential novel ligand-receptor interaction for histatin peptides. Our long
term objective is to develop a new class of DED and OSD therapeutics which are non-toxic and anti-
inflammatory. Our central hypothesis is that histatin peptides can ameliorate the inflammatory effects of toxic
and inflammatory insults to corneal epithelia in vitro and in vivo. We will utilize well vetted models of toxic
epitheliopathy, hyperosmolarity and desiccation in order to show the efficacy of histatin peptides in treating
OSDs. We will also undertake studies to find receptors for histatin peptide. The proposed research is innovative
as it is the first study to investigate the use of histatin peptides in the treatment of DED and OSD. These studies
are significant because they will advance the development of new therapeutics through the use of rigorous and
well defined methods in clinically relevant translational models of disease and validate a novel receptor-ligand
relationship.
项目描述/文摘
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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Vinay Aakalu其他文献
Vinay Aakalu的其他文献
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{{ truncateString('Vinay Aakalu', 18)}}的其他基金
Novel Treatments for Modulation of Innate Immunity in Veteran Related Eye Diseases
调节退伍军人相关眼病先天免疫的新疗法
- 批准号:
9562360 - 财政年份:2018
- 资助金额:
$ 39.98万 - 项目类别:
Novel Treatments for Modulation of Innate Immunity in Veteran Related Eye Diseases
调节退伍军人相关眼病先天免疫的新疗法
- 批准号:
10292904 - 财政年份:2018
- 资助金额:
$ 39.98万 - 项目类别:
Novel Treatments for Modulation of Innate Immunity in Veteran Related Eye Diseases
调节退伍军人相关眼病先天免疫的新疗法
- 批准号:
10046282 - 财政年份:2018
- 资助金额:
$ 39.98万 - 项目类别:
Novel Treatments for Modulation of Innate Immunity in Veteran Related Eye Diseases
调节退伍军人相关眼病先天免疫的新疗法
- 批准号:
10516064 - 财政年份:2018
- 资助金额:
$ 39.98万 - 项目类别:
Study of Accessory Lacrimal Gland and Precursor Cell Biology
副泪腺及前体细胞生物学研究
- 批准号:
9044784 - 财政年份:2014
- 资助金额:
$ 39.98万 - 项目类别:
Study of Accessory Lacrimal Gland and Precursor Cell Biology
副泪腺及前体细胞生物学研究
- 批准号:
8679183 - 财政年份:2014
- 资助金额:
$ 39.98万 - 项目类别:
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