Glycomics Laboratory for the Development of Ovarian Cancer Biomarkers

卵巢癌生物标志物开发糖组学实验室

基本信息

项目摘要

ABSTRACT Ovarian cancer is a silent killer with few early symptoms and advanced disease often present at the time of diagnosis. This cancer is the most lethal of all gynecologic malignancies with over 20,000 new cases diagnosed each year. The 5 year survival rates for ovarian cancer dramatically improve when the disease is diagnosed at an earlier stage. Therefore, the long term goal of the Glycomics Laboratory for the Development of Ovarian Cancer Biomarkers is to apply the most advanced technologies toward the goal of identifying glycoprotein and glycan markers that can detect ovarian cancer early. We are a multidisciplinary team with expertise in cancer biology, glycomics, glycan array analysis, and translational glycoimmunology from investigators at the University of Arkansas for Medical Sciences (UAMS), the Complex Carbohydrate Research Center (CCRC) at the University of Georgia, and the Harvard Medical School Center for Glycoscience at Harvard University. The investigators at UAMS specialize in biomarker discovery using glycomic methods and functional studies of glycosyltransferase enzymes in ovarian cancer progression, the co-investigators at the CCRC specialize in the mass spectrometry identification of O-linked glycans present on the Notch receptor and the functional analysis of these glycans in Notch activation, and the co-investigators at Harvard specialize in the development of antibodies binding to tumor-specific glycans and the development of glycopeptide arrays. The aims of this application are (1) To develop and validate N-linked and O-linked glycoforms for the detection of ovarian cancer and (2) To discover and develop glycosylphosphatidylinositol (GPI) anchored protein glycoforms and GPI anchor binding proteins for the detection of ovarian cancer.
摘要

项目成果

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KAREN L. ABBOTT其他文献

KAREN L. ABBOTT的其他文献

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{{ truncateString('KAREN L. ABBOTT', 18)}}的其他基金

Glycomics Laboratory for the Development of Ovarian Cancer Biomarkers
卵巢癌生物标志物开发糖组学实验室
  • 批准号:
    10299805
  • 财政年份:
    2020
  • 资助金额:
    $ 14.08万
  • 项目类别:
Glycomics Laboratory for the Development of Ovarian Cancer Biomarkers
卵巢癌生物标志物开发糖组学实验室
  • 批准号:
    10418619
  • 财政年份:
    2020
  • 资助金额:
    $ 14.08万
  • 项目类别:
Novel Platform linking cancer-specific glycosylation with cell signaling outcomes
将癌症特异性糖基化与细胞信号转导结果联系起来的新平台
  • 批准号:
    10253467
  • 财政年份:
    2018
  • 资助金额:
    $ 14.08万
  • 项目类别:
Glycomics Laboratory for the Early Detection of Epithelial Ovarian Cancer
早期检测上皮性卵巢癌的糖组学实验室
  • 批准号:
    9102043
  • 财政年份:
    2012
  • 资助金额:
    $ 14.08万
  • 项目类别:
Glycomics Laboratory for the Early Detection of Epithelial Ovarian Cancer
早期检测上皮性卵巢癌的糖组学实验室
  • 批准号:
    8700350
  • 财政年份:
    2012
  • 资助金额:
    $ 14.08万
  • 项目类别:
Glycomics Laboratory for the Early Detection of Epithelial Ovarian Cancer
早期检测上皮性卵巢癌的糖组学实验室
  • 批准号:
    8539587
  • 财政年份:
    2012
  • 资助金额:
    $ 14.08万
  • 项目类别:
Glycomics Laboratory for the Early Detection of Epithelial Ovarian Cancer
早期检测上皮性卵巢癌的糖组学实验室
  • 批准号:
    8351959
  • 财政年份:
    2012
  • 资助金额:
    $ 14.08万
  • 项目类别:

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