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The cell and gene therapy toolkit for junior faculty

初级教师的细胞和基因治疗工具包

基本信息

批准号：
9903575
负责人：
STEPHAN A. GRUPP
金额：
$ 31.97万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9903575
关键词：
Address Area Basic Science Biological Markers Biomanufacturing Blindness Cancer Center Cancer Research Project Cell Therapy Cells Childhood Clinic Clinical Clinical Research Clinical Trials Clinical Trials Design Collaborations Complex Data Development Educational Curriculum Environment Ethics Event FDA approved Faculty Foundations Funding Future Gene Therapy Agent Genes Goals Immunobiology Immunotherapy Industrialization Inherited Intellectual Property Investigation Knowledge Laboratories Leadership Malignant Neoplasms Methods Pediatric Hospitals Pennsylvania Perception Persons Philadelphia Problem Solving Program Development Protocols documentation Public Relations Recording of previous events Regulation Request for Applications Research Research Personnel Research Training Science Scientist Specialist Technology Testing Therapeutic Training Translating Translational Research Translations Universities Work Workforce Development anticancer research base cancer therapy career commercial application commercialization design early-career faculty education research experience gene therapy improved interest meetings next generation novel pre-clinical preclinical safety programs recruit response skill acquisition skills success therapeutic development therapy development tool translational cancer research translational pipeline vector virtual

项目摘要

Project Summary/Abstract To meet the need for a cancer research workforce in rapidly emerging areas of cancer therapeutics, we propose a short course in the science and translation of cell and gene therapy. Our objective is to train a cadre of junior faculty level NCI-funded investigators in critical skills related to cell and gene therapy to accelerate their work. The course covers foundations, preclinical tools, protocols for biomanufacturing, intellectual property, regulatory compliance, clinical trial design and systemic challenges in collaborative science. The program is organized by module and provides learners numerous opportunities to interact with faculty 1-on-1 and in group settings. The contributing faculty are pioneers in the field of cell and gene therapy across the translational spectrum from discovery to the first FDA approvals of both cell and gene therapy products, and have been responsible for major advances at Penn, CHOP, the Abramson Cancer Center and globally. In addition to basic scientists, the faculty includes experts and specialists in areas key to translating immunobiology into clinical trials, including specialists in translational and clinical research, biomarker characterization for cell and gene therapy, regulatory science, and commercial collaboration. Although focused on a specific set of topics in cancer research, the theme of cell and gene therapy is increasingly relevant to many aspects of cancer research, and our preliminary data suggests that interest among early NCI- funded investigators is broad. This supports our hypothesis that research training in these topics is essential and increasingly relevant and generalizable to most cancer research programs. Overall, this program will provide NCI-funded junior investigators with critical tools to harness the latest advances in the field of cell and gene therapy to translate their own findings into successful cancer therapies.

项目总结/文摘