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Modality specific naming assessment across the age span

跨年龄段的特定命名评估

基本信息

批准号：
9906286
负责人：
MARLA J HAMBERGER
金额：
$ 8.1万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-15 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9906286
关键词：
Address Adolescence Adolescent and Young Adult Adult Age Alzheimer&apos s Disease Appearance Area Auditory Child Childhood Clinical Common Data Element Cues Data Data Collection Dissociation Early Diagnosis Elderly Epilepsy Evaluation Excision Exhibits Fatigue Foundations Functional disorder Gender Goals Handedness Human Impairment Individual Inferior Infrastructure Intractable Epilepsy Laboratories Language Left Longevity Measures Mediating Modality Names National Institute of Neurological Disorders and Stroke Neuropsychology Occupational Operative Surgical Procedures Participant Patients Performance Play Postoperative Period Primary Progressive Aphasia Process Production Progressive Disease Property Psychometrics Publishing Reaction Time Research Research Personnel Risk Role Sample Size Sampling Seizures Standardization Stimulus Symptoms Telephone Temporal Lobe Temporal Lobe Epilepsy Testing Thinking Update Validation Visual Work age effect base clinically relevant cognitive neuroscience cortex mapping early awareness experience improved individual patient middle age nervous system disorder neurocognitive disorder performance tests prevent sex social young adult

项目摘要

Project Summary The ability to produce the correct words while speaking is critical for social, academic and occupational functioning. Unfortunately, word finding or “naming” can become impaired in a number of neurological disorders involving cortical function, and thus, naming assessment is an integral component of neuropsychological evaluation. As naming is mediated by the temporal lobe region, naming assessment plays a critical role in the evaluation of temporal lobe epilepsy (TLE) patients. Our initial work in this area addressed multiple shortcomings in naming assessment in epilepsy, which historically, was limited to visual object naming. Through cortical mapping, we found a dissociation between cortical areas that support naming based on visual versus auditory cues. In line with this, the auditory naming and complementary visual naming tests we developed and standardized (published in 2003) were found to assist in lateralizing and localizing cortical dysfunction associated with seizure onset, thereby aiding the presurgical evaluation for refractory epilepsy patients. Based on this initial work, we developed and standardized pediatric versions of these measures, and will soon complete standardization of auditory and complementary visual naming tests for older adults, ages 56-95. Importantly, the original tests which included only adults up to age 55, did not adequately consider longevity of the stimuli, and the normative data were limited. We continue to receive numerous requests for these tests; however, the original tests are not up to current standards, leaving a critical gap in high quality naming assessment for ages 16-55, when the vast majority of epilepsy surgeries are performed. Based on years of experience with the original measures, the pediatric and older-adult naming tests are vastly improved with regard to psychometric properties and normative data. The stimuli in the older-adults tests are also very well-suited for adolescents and younger adults. Capitalizing on our laboratory infrastructure and experience, the proposed project will upgrade the tests and normative data to current standards for ages 16-55, and validate these measures in left (dominant) and right TLE patients, enabling continued use of auditory and visual naming in younger adults with epilepsy, earlier detection of language decline in the context of degenerative processes, and more generally, provide high quality naming assessment for adolescence through late adulthood for any neurocognitive disorder.

项目总结