Psychosocial Context and the Biological Clock: Changes in Weathering during Middle-Age

心理社会背景和生物钟：中年风化的变化

• 批准号: 9908032
• 负责人: Ronald L Simons
• 金额: $ 60.17万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9908032
• 关键词: Adult; Adult Children; African American; Age; Aging; Biological; Biological Aging; Biological Assay; Biological Clocks; Biological Markers; Blood; Buffers; Child; Childhood; Chronic Disease; Chronology; Communities; Couples; Data; Data Collection; Development; Discrimination; Disease; Early identification; Economics; Elderly; Epigenetic Process; Ethnic group; Family; Family Relationship; Family and Community Health Study; Family member; Fostering; Foundations; Glean; Goals; Growth; Health Policy; High Prevalence; Individual; Inequality; Inflammatory; Intervention; Intervention Studies; Interview; Knowledge; Label; Life; Life Cycle Stages; Life Experience; Literature; Maps; Measurement; Measures; Modeling; Molecular; Mothers; Occupations; Pattern; Personal Satisfaction; Physiological; Prevention; Prevention program; Process; Psychosocial Assessment and Care; Psychosocial Factor; Public Health; Race; Religion and Spirituality; Research; Research Personnel; Respondent; Risk; Role; Scientist; Smoking; Social Conditions; Social support; Specific qualifier value; Speed; Spouses; Stress; Technology; Testing; Time; Translating; Weather; age effect; age related; cohesion; contagion; design; diet and exercise; early childhood; early onset; effective intervention; expectation; experience; family influence; healthy aging; high risk; improved; indexing; insight; intervention program; lifestyle factors; longitudinal dataset; methylomics; middle age; molecular marker; mortality; offspring; psychological stressor; psychosocial; public health intervention; response; social; social stressor; stressor; treatment strategy; young adult

PROJECT SUMMARY Unprecedented growth in the proportion of older adults in the U.S. has placed inequalities in healthy aging at the forefront of the public health agenda. Individuals often differ dramatically in their speed of aging. Some demonstrate accelerated aging and suffer early onset of chronic illness whereas others manifest decelerated aging and stave off serious illness well into their 90s. In recent years, researchers have made much headway in understanding the molecular markers of healthy aging, thereby allowing for earlier identification of risk for chronic disease. The proposed research focuses on two such biomarkers of healthy aging – inflammatory aging and methylomic aging. These measures provide us with “biological clocks” that are strongly predictive of age-related physiological decline, disease, and mortality. Having established these molecular measures of the speed of aging, the important question for social scientists and health policy now becomes: To what extent is the speed of aging malleable, for better or worse, in response to natural shifts in psychosocial contexts? This question is the focus of the present proposal. We plan to investigate the extent to which adult social conditions from various domains, but especially those operating within the family, influence speed of biological aging after taking into account childhood experiences and potentially confounding life style factors such as diet, exercise, and smoking. Our objective is to identify the stressors that accelerate aging as well as the supports that decelerate aging. These goals will be pursued using longitudinal data from the Family and Community Health Study (FACHS), a 20-year study of well-being among African American mothers, their romantic partners (RPs), and their offspring. A focus on aging among African Americans is important as they tend to suffer from earlier onset and higher prevalence of age-related diseases and a wider range of psychosocial stressors than other ethnic groups. First, we will obtain longitudinal indices of the speed of inflammatory and methylomic aging from the now middle-aged mothers and, if partnered, their RPs by collecting and assaying a new wave of blood data, as well as assaying stored blood from a previous wave. The proposed data will provide the first comprehensive assessment of change in the speed or rate of biological aging during adulthood. Second, we will collect an additional wave of interview data so that changes in supports and stressors can be mapped onto changes in the rate of biological aging.

项目摘要 美国老年人比例的空前增长使健康状况不平等。 老龄化是公共卫生议程的前沿。不同的人在他们的速度上往往有很大的差异。 衰老有些人表现出加速老化和遭受慢性疾病的早期发作，而另一些人 在90多岁的时候还能延缓衰老，避免患上严重疾病。近年来，研究人员 在了解健康衰老的分子标志物方面取得了很大进展， 以便及早识别慢性疾病的风险。研究重点是两个这样的 健康衰老的生物标志物-炎症性衰老和甲基化衰老。这些措施为我们 与“生物钟”是强烈预测与年龄有关的生理衰退，疾病， mortality.在建立了这些衰老速度的分子测量方法之后，重要的问题是， 对于社会科学家和健康政策来说，现在变成了：衰老的速度在多大程度上是可塑的， 是好是坏，以应对心理社会背景下的自然变化？这个问题是重点 目前的提案。我们计划调查成年人的各种社会条件在多大程度上影响了他们的行为。 领域，但特别是那些在家庭内运作，影响生物老化后的速度， 考虑到童年经历和潜在的混淆生活方式因素，如饮食， 锻炼和吸烟。我们的目标是找出加速衰老的压力源以及 支持延缓衰老。这些目标将使用来自家庭的纵向数据来实现。 社区健康研究（FACHS），一项为期20年的非裔美国人健康研究 母亲，他们的浪漫伴侣（RP）和他们的后代。关注非裔美国人的老龄化 是重要的，因为他们往往更早发病，更容易患上与年龄有关的疾病， 比其他种族群体更广泛的心理社会压力。首先，我们将获得纵向 炎症和甲基化衰老速度的指标，从现在的中年母亲，如果 通过收集和分析新一波血液数据，以及分析存储的 上一波的血拟议的数据将提供第一次全面评估， 成年期生物老化速度或速率的变化。第二，我们将收集额外的 一波访谈数据，以便支持和压力源的变化可以映射到 生物老化的速度。