Mapping and manipulating circuits for relapse and abstinence

酒精使用障碍和其他药物成瘾是慢性复发性疾病。目前的治疗方法只有适度的疗效。要真正改善，需要两个方面的进展。第一个是在细胞和电路水平上解析支持禁欲和复发的大脑机制。第二种是以同样的精度治疗性地瞄准这些回路。该项目为下一代治疗学奠定了基础科学平台。

Alcohol-use disorders and other drug addictions are chronically relapsing conditions. Current treatment approaches have only modest efficacy. Two advances are needed for genuine improvement. The first is parsing the brain mechanisms supporting abstinence and relapse at cellular as well as circuit levels. The second is targeting these circuits therapeutically with the same precision. This project contributes to the first advance and lays a basic science platform for next generation therapeutics.