Contextual control over relapse to drug seeking: Behavioural and neural mechanisms.

对药物寻求复发的情境控制：行为和神经机制。

• 批准号: nhmrc : 350879
• 负责人: Prof Gavan Mcnally
• 金额: $ 26.39万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/contextual-control-relapse-neural-mechanisms/77899
• 关键词: Contextual; control; over; relapse; drug

Drug addiction is a major health and societal problem in Australia. It is consistently associated with an adverse impact upon individual users, their families, and communities. Prolonged drug use is associated with increased rates of physical problems (e.g., cardiovascular disease), mental health problems (e.g., depression and anxiety), and criminal involvement (e.g., property crimes and incarceration). A defining feature of drug addiction is that it is a chronically relapsing condition. Between 60-80% of addicts attempting to give up drug taking will relapse to drug taking. The behavioural and brain mechanisms which underpin this persistent propensity to relapse are largely unknown. This project studies the behavioural and brain mechanisms for relapse to drug addiction. This project uses a well validated animal model of drug taking to ask why relapse occurs. It will identify some of the environmental antecedents to relapse and the brain mechanisms which mediate relapse. As such, this project will project will provide important information about relapse to drug addiction and may help identify targets for therapeutic intervention and possibly disrupt the addictive cycle.

吸毒成瘾是澳大利亚的一个主要健康和社会问题。它始终与对个人用户，他们的家庭和社区的不利影响有关。长期使用药物与身体问题的发生率增加有关（例如，心血管疾病），精神健康问题（例如，抑郁和焦虑），以及犯罪参与（例如，财产犯罪和监禁）。吸毒成瘾的一个明确特征是它是一种慢性复发性疾病。60-80%的吸毒者试图放弃吸毒，但最终会复吸。这种持续复发倾向的行为和大脑机制在很大程度上是未知的。这个项目研究药物成瘾复发的行为和大脑机制。这个项目使用了一个经过充分验证的动物模型来研究为什么会复发。它将确定一些复发的环境前因和介导复发的大脑机制。因此，该项目将提供有关药物成瘾复发的重要信息，并可能有助于确定治疗干预的目标，并可能破坏成瘾循环。