A turnkey research platform to accelerate clinical translation of focused-ultrasound (FUS) oncology therapies

加速聚焦超声 (FUS) 肿瘤疗法临床转化的交钥匙研究平台

• 批准号: 9908739
• 负责人: Ryan Gessner
• 金额: $ 30万
• 依托单位: SONOVOL, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-11 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9908739
• 关键词: 3-Dimensional; Ablation; Acceleration; Acoustics; Address; Algorithms; Animal Model; Animals; Area; Basic Science; Breast Cancer Model; Clinic; Clinical; Collaborations; Complex; Computer software; Coupling; Data; Detection; Development; Devices; Dose; Drug Delivery Systems; Engineering; Ensure; Equipment; Focused Ultrasound; Focused Ultrasound Therapy; Foundations; Frequencies; Image; Immunization; Immunologist; Immunology; Immunotherapy; In Vitro; Industry; Institution; Location; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Measures; Modality; Monitor; Neurology; Operative Surgical Procedures; Output; Pharmaceutical Preparations; Phase; Physicians; Radiation; Reproducibility; Research; Research Personnel; Robotics; Rodent Model; Scanning; Site; Standardization; Surgical incisions; Surveys; System; Techniques; Technology; Temperature; Testing; Therapeutic; Therapeutic Human Experimentation; Thermal Ablation Therapy; Thermometry; Three-Dimensional Image; Tissues; Traction; Transducers; Translations; Ultrasonic Transducer; United States National Institutes of Health; Validation; Work; anti-cancer therapeutic; anticancer treatment; base; cancer therapy; clinical application; clinical translation; clinically translatable; commercialization; experimental study; flexibility; follow-up; image guided; in vivo; innovation; mouse model; new technology; novel; oncology; pre-clinical; pressure; research and development; software development; sonoporation; tool; treatment planning; treatment strategy

Abstract Focused ultrasound (FUS) is an early-stage, noninvasive therapeutic technology with great potential in oncology. FUS could potentially offer either an alternative or complementary strategy to existing cancer treatment approaches such as surgery, radiation, and immunotherapy. While FUS technology has some initial traction, there are still many unknowns about how best to deliver FUS and mechanisms of action. The work proposed herein will result in a platform that will accelerate the translational pace of this promising treatment modality. SonoVol is proposing to build and validate a novel FUS guidance, treatment, and assessment platform for small animals. The system will be deployed in SonoVol’s Vega, a robotically controlled volumetric scanning device for high-throughput preclinical imaging. Unlike conventional FUS research solutions, the new 3D image guided “TherUS” Platform will ensure accurate and repeatable FUS dose delivery irrespective of user or sonographer expertise. TherUS will accelerate FUS clinical translation by lowering the technological barriers which limit widespread access, putting the technology directly in the hands of the broader market of cancer biologists and immunologists to develop cutting-edge anticancer treatment strategies, including immunotherapy approaches. This work will proceed via three stages. First, we will develop hardware to allow accurate and repeatable dose delivery via multiple FUS transducers within the same study. Two transducers with center frequencies of 0.5 and 2 MHz will be installed in a robotic carriage and the pressure fields will be mapped to allow spatial localization with the guidance and follow up transducers. Second, we will develop software to facilitate treatment planning and confirmation of dose delivery. We will create a module to allow registration to previous timepoints, as well as dose confirmation algorithms within SonoVol’s software for thermometry and cavitation detection. Finally, we will compare accuracy, repeatability, and reproducibility of TherUS against a conventional top-down FUS system and prove in vivo feasibility with an ablation study in a mouse model of breast cancer.

摘要 聚焦超声（FUS）是一种早期、无创治疗技术，在治疗恶性肿瘤方面具有巨大潜力。 肿瘤学FUS可能为现有癌症提供替代或补充策略 治疗方法，如手术，放射和免疫疗法。虽然FUS技术有一些初步的 尽管有很大的吸引力，但在如何最好地提供FUS和行动机制方面仍有许多未知数。工作 本文提出的方法将产生一个平台，该平台将加速这种有前途的治疗的转化步伐 模态Sonopoly提出建立和验证一种新的FUS指导，治疗和评估 小动物的平台。该系统将被部署在Sonopolis的织女星，一个机器人控制的体积 用于高通量临床前成像的扫描设备。与传统的FUS研究解决方案不同， 3D图像引导的“TherUS”平台将确保准确和可重复的FUS剂量输送， 用户或超声医师专业知识。TherUS将通过降低技术成本， 限制广泛获取的壁垒，将技术直接掌握在更广泛的市场手中， 癌症生物学家和免疫学家开发尖端的抗癌治疗策略，包括 免疫治疗方法。这项工作将分三个阶段进行。首先，我们将开发硬件， 在同一研究中通过多个FUS换能器进行精确和可重复的剂量输送。两个换能器 中心频率为0.5和2 MHz的传感器将安装在机器人托架上， 映射以允许利用引导和跟踪换能器进行空间定位。第二，我们将发展 软件，以促进治疗计划和剂量输送的确认。我们将创建一个模块， 与先前时间点的配准，以及Sonopoly软件中的剂量确认算法， 温度测量和气穴检测。最后，我们将比较的准确性，重复性和再现性， TherUS与传统的自上而下的FUS系统进行比较，并通过消融研究证明体内可行性。 小鼠乳腺癌模型。