Evolving Our Partnership: The CSER2 Centralized Support Coordinating Center

摘要 临床测序探索性研究竞争性更新提案的总体目标 (CSER)联合体协调中心(CC)是为了提高下一阶段CSER的有效性 (CSER2)确保推动跨财团所需的有效协调和后勤支持 努力，并确定新的协同作用，以增加个别项目的科学价值。CSER2 将继续产生临床基因组医学所需的证据基础，扩大其覆盖范围 向非学术中心转移，增强患者群体的多样性。它将及时提供， 有关基因组医学最佳实践的实用信息，可提供有用和 为医生、患者、家庭成员和政策制定者提供可访问的建议。在接近中 在这项任务中，我们将利用我们作为现有CSER CC和作为 许多其他基因组学联盟，包括在不同的和非学术群体中的专业知识，以促进 CSER2的工作。在当前的CSER(CSER1)周期中，UW CC取得了许多重大进展 对CSER重要工作的贡献，如进度部分所述。我们的成功在于 每个CSER1 UO1站点的PI支持UW继续作为CSER2 CC这一事实突显了这一点。 具体目标 目标1：提供领导、组织和后勤支持，以促进和整合 CSER2联合体、其小组委员会和工作取得成功所需的活动 组。 目标2：提供独特的专业知识，以促进关键领域的卓越和财团范围的产品 计划领域：ELSI(伦理、法律和社会影响)、医学遗传学和护理 整合、测序技术和序列分析、信息学和电子学 病历整合、健康经济学和以患者为中心的结果。 目标3：优化CSER2数据和产品的开发和分发，并促进 与其他相关的NIH项目和更大的利益相关者社区的互动。

Abstract The overall goal in this competitive renewal proposal for the Clinical Sequencing Exploratory Research (CSER) Consortium coordinating center (CC) is to enhance the effectiveness of the next CSER phase (CSER2) by assuring the effective coordination and logistic support needed to propel cross-consortium efforts and to identify new synergies that increase the scientific value of the individual projects. CSER2 will continue to generate the evidence base required for clinical genomic medicine, expanding its reach into non-academic centers and enhancing the diversity of the patient groups. It will provide timely, pragmatic information about best practices for genomic medicine that permit optimal provide useful and accessible recommendations for physicians, patients, family members, and policymakers. In approaching this task, we will leverage our considerable experience as the existing CSER CC and as partners in many other genomics consortia, including expertise in diverse and non-academic populations to facilitate the work of CSER2. In the current cycle of CSER (CSER1) the UW CC has made numerous significant contributions to the important work of CSER, as outlined in the progress section. Our success is underscored by the fact that the PIs at every CSER1 UO1 site support UW continuing as the CSER2 CC. Specific Aims Aim1: Provide the leadership, organizational, and logistical support to facilitate and integrate the activities required for the success of the CSER2 consortium, its subcommittees, and work groups. Aim 2: Provide unique expertise to facilitate excellence and consortium-wide products in the key program areas: ELSI (ethical, legal, and social implications), medical genetics and care integration, sequencing technology and sequence analyses, informatics and electronic medical record integration, health economics, and patient-centered outcomes. Aim 3: Optimize development and distribution of CSER2 data and products and facilitate interactions with other relevant NIH programs and with the larger community of stakeholders.