Intergenerational Neuroimaging of Language and Reading Networks Using a Natural Cross-Fostering Design
使用自然交叉培养设计的语言和阅读网络的代际神经影像
基本信息
- 批准号:9912647
- 负责人:
- 金额:$ 70.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-10 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAgeAnimal ExperimentationAnimal ModelAnimalsBehavioralBehavioral ResearchBiologicalBiological ModelsBrainBrain regionChildCognitiveComplexConceptionsDaughterDevelopmentDevelopmental reading disorderDorsalEarly InterventionEnvironmental Risk FactorExposure toFamilyFamily memberFathersFertilization in VitroFormulationFosteringFoundationsGeneral PopulationGeneticGenetic studyGestational surrogateHumanIndividual DifferencesInterventionInvestigationKnowledgeLanguageLearning DisordersMagnetic Resonance ImagingMathematicsMeasuresMediatingMothersNeurobiologyNeurocognitive DeficitNewborn InfantOrthographyOutcomeParentsPathway interactionsPatternPhenotypePrevalencePrevention strategyProceduresProcessProtocols documentationPublishingReadingReading DisorderResearchRiskSex DifferencesSiteSonStructureTimeTranslationsTriad Acrylic Resinagedbasebehavioral phenotypingdesigneggintergenerationallanguage processingmultimodalityneurodevelopmentneuroimagingnon-geneticnovel strategiesoffspringphonologypostnatalprenatalprenatal influenceprotective factorsrecruitrelating to nervous systemsexskillssperm cellsuccesstraittransmission process
项目摘要
ABSTRACT
The main objective of the proposed research is to examine, for the first time, intergenerational transmission of
human brain networks using a natural cross-fostering design. We take reading-related brain networks, in
particular those related to phonological and orthographic processing (as well as in language- and more
preliminarily in math-related processes), as model systems because of the potentially differential impact of
genetic and environmental factors on these networks and corresponding behavioral phenotypes. In addition,
impairment of these neurocognitive processes is associated with specific learning disorder of word reading
(aka decoding-based reading disorder [RD] or developmental dyslexia) that has a lifetime prevalence of 5-
10%, and an increased risk of the offspring developing RD by 4 to 8 times the general population with an
immediate family member with RD. The proposed natural cross-fostering design addresses a critical question
about the mechanisms of intergenerational effects, i.e., whether they are genetic (G), prenatal (PreE) or
postnatal environmental (PostE) in origin. This is only now possible with the widespread availability of in-vitro
fertilization (IVF). We will obtain cognitive measures, and functional and structural MRI, in healthy families
(triads) at a pace of 30 families per site per year. We will examine parent-offspring correlations, including brain-
brain correlations, across four groups of IVF children that receive distinctive G/PreE/PostE contributions from
their rearing parents as well as a fifth group of naturally conceived children (N=60 triads per group, with
children of ages 8-11, half with daughters and the other half with sons): (1) the HOMOLOGOUS group in which
offspring conceived through IVF are borne and reared by their genetic parents, thus being exposed to maternal
and paternal G/PreE/PostE influences; (2) the DONOR EGG and (3) DONOR SPERM groups, in which
offspring are conceived from donor eggs/sperm, and hence rearing mothers/fathers only have PreE/PostE, not
G, influence on their offspring; (4) the gestational SURROGACY group in which offspring are borne through
non-genetic, non-rearing mothers, and hence rearing parents only have G/PostE but no PreE influences over
their offspring; and (5) the NATURAL conception group in which naturally conceived offspring are borne and
reared by their genetic parents, thus being exposed to maternal and paternal G/PreE/PostE influences and
without the influence of IVF. Fathers’ PreE influence is typically considered minimal. The specific aims of the
proposal are: to examine parent-offspring (dyad) correlations, to examine the extent to which environmental and
genetic factors contribute to shared variance in reading- and language-related cognitive and neurobiological
processes, to examine parent-of-origin effects, and to dissociate G, PreE and PostE influences. A successful
outcome will establish a new paradigm for studying genetic and environmental influences on brain networks,
and ultimately provide us with important information about risk/protective factors, windows of opportunity to
intervene, and development of early intervention and preventive strategies of RD.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
FUMIKO HOEFT其他文献
FUMIKO HOEFT的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('FUMIKO HOEFT', 18)}}的其他基金
Intergenerational Neuroimaging of Language and Reading Networks Using a Natural Cross-Fostering Design
使用自然交叉培养设计的语言和阅读网络的代际神经影像
- 批准号:
10403943 - 财政年份:2019
- 资助金额:
$ 70.93万 - 项目类别:
Neural Mechanisms Underlying Compensation in Dyslexia
阅读障碍补偿的神经机制
- 批准号:
10215578 - 财政年份:2018
- 资助金额:
$ 70.93万 - 项目类别:
Neural Mechanisms Underlying Compensation in Dyslexia
阅读障碍补偿的神经机制
- 批准号:
9977786 - 财政年份:2018
- 资助金额:
$ 70.93万 - 项目类别:
Neural Mechanisms Underlying Compensation in Dyslexia
阅读障碍补偿的神经机制
- 批准号:
10442430 - 财政年份:2018
- 资助金额:
$ 70.93万 - 项目类别:
Neurochemistry as a moderator of brain networks for reading
神经化学作为阅读大脑网络的调节者
- 批准号:
9975908 - 财政年份:2016
- 资助金额:
$ 70.93万 - 项目类别:
Neurochemistry as a moderator of brain networks for reading
神经化学作为阅读大脑网络的调节者
- 批准号:
9176803 - 财政年份:2016
- 资助金额:
$ 70.93万 - 项目类别:
Understanding literacy acquisition through immersion in foreign languages
了解通过沉浸式外语获得读写能力
- 批准号:
9525139 - 财政年份:2015
- 资助金额:
$ 70.93万 - 项目类别:
Understanding literacy acquisition through immersion in foreign languages
了解通过沉浸式外语获得读写能力
- 批准号:
9316356 - 财政年份:2015
- 资助金额:
$ 70.93万 - 项目类别:
Understanding literacy acquisition through immersion in foreign languages
了解通过沉浸式外语获得读写能力
- 批准号:
9135439 - 财政年份:2015
- 资助金额:
$ 70.93万 - 项目类别:
Understanding literacy acquisition through immersion in foreign languages
了解通过沉浸式外语获得读写能力
- 批准号:
9729456 - 财政年份:2015
- 资助金额:
$ 70.93万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 70.93万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 70.93万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 70.93万 - 项目类别:
Fellowship
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 70.93万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 70.93万 - 项目类别:
Continuing Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 70.93万 - 项目类别:
Standard Grant
The economics of (mis)information in the age of social media
社交媒体时代(错误)信息的经济学
- 批准号:
DP240103257 - 财政年份:2024
- 资助金额:
$ 70.93万 - 项目类别:
Discovery Projects
How age & sex impact the transcriptional control of mammalian muscle growth
你多大
- 批准号:
DP240100408 - 财政年份:2024
- 资助金额:
$ 70.93万 - 项目类别:
Discovery Projects
Supporting teachers and teaching in the age of Artificial Intelligence
支持人工智能时代的教师和教学
- 批准号:
DP240100111 - 财政年份:2024
- 资助金额:
$ 70.93万 - 项目类别:
Discovery Projects
Enhancing Wahkohtowin (Kinship beyond the immediate family) Community-based models of care to reach and support Indigenous and racialized women of reproductive age and pregnant women in Canada for the prevention of congenital syphilis
加强 Wahkohtowin(直系亲属以外的亲属关系)以社区为基础的护理模式,以接触和支持加拿大的土著和种族育龄妇女以及孕妇,预防先天梅毒
- 批准号:
502786 - 财政年份:2024
- 资助金额:
$ 70.93万 - 项目类别:
Directed Grant