Transdiagnostic Neural Mechanisms Underlying Dimensions of Negative Affectivity in Depression and Anxiety

抑郁和焦虑中消极情感维度的跨诊断神经机制

• 批准号: 9912199
• 负责人: Jay C Fournier
• 金额: $ 54.48万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9912199
• 关键词: Acute; Amygdaloid structure; Anger; Anterior; Anxiety; Anxiety Disorders; Brain; Clinical; Conflict (Psychology); Conscious; Data; Depressive disorder; Dimensions; Distress; Dorsal; Emotional; Emotions; Ensure; Functional disorder; Future; Goals; Grain; Hostility; Impairment; Individual; Lead; Measures; Mental Depression; Mental disorders; Modeling; Mood Disorders; National Institute of Mental Health; Nature; Neurobiology; Neuronal Dysfunction; Occupational; Participant; Pattern; Phenotype; Prefrontal Cortex; Process; Productivity; Protocols documentation; Psychiatric Diagnosis; Psychopathology; Public Health; Regulation; Research Domain Criteria; Rest; Severities; Shame; Symptoms; System; Testing; Visit; Work; anxiety symptoms; base; brain abnormalities; cingulate cortex; cognitive control; depressive symptoms; diaries; emotion regulation; emotional experience; experience; follow up assessment; follow-up; functional outcomes; humiliation; improved; individualized medicine; interest; negative affect; network dysfunction; neural circuit; neural model; neural patterning; neurobiological mechanism; neuroimaging; neuroimaging marker; neuromechanism; novel; personalized medicine; prospective; psychiatric symptom; recruit; relating to nervous system; response; secondary analysis; young adult

ABSTRACT There is growing recognition that strict distinctions between clinical psychiatric disorders such as anxiety and depression, on the one hand, and more stable dispositions to experience negative emotions (negative affectivity), on the other, fail to capture the true nature of psychopathology. We argue that by examining specific dimensional phenotypes that cut across depression and anxiety disorders, we will be better able to identify the neurobiological processes that are specifically associated with an individual's distress and dysfunction – a critical step for developing more effective, targeted treatments. Negative affectivity is a broad dimension that underlies depression and anxiety and is associated with enormous public health consequences. One of the specific facets of negative affectivity, excessive self-consciousness, may represent a dimensional phenotype that is closely aligned with a specific pattern of dysfunction in neural mechanisms that can lead to difficulties regulating emotional responses. Excessive self-consciousness refers to the tendency to feel shame, humiliation, and inadequacy. Our preliminary data suggest that it is strongly associated with altered functioning in self-related processing neural regions and in regions responsible for emotion regulation, over and above acute psychiatric symptoms. Furthermore, our findings suggest that excessive self-consciousness is strongly associated with specific types of real-world interpersonal problems. The primary goals of this project are to test a novel model of neural dysfunction during emotion regulation associated with excessive self-consciousness and to examine the real-world consequences of that dysfunction. To achieve these goals, 125 young adults (18-25 years old) with at least mild symptoms of depression or anxiety will be recruited. In addition, 75 demographically matched, psychiatrically healthy individuals will be recruited to ensure that we capture the full range for all of the dimensions of interest. Participants will complete clinical and neuroimaging assessments, as well as 6- and 12-month follow-up assessments that will include weeklong daily diary protocols of real-world functioning. The project will examine 1) whether excessive self-consciousness is associated with abnormal functioning in self-related processing regions; 2) whether excessive self-consciousness is associated with abnormalities in the functioning of the emotion regulation circuit; and 3) whether abnormalities in these neural systems prospectively predict psychiatric symptoms and poorer interpersonal and work functioning 6 and 12 months later. The aims of the project match well with the strategic goals of the National Institute of Mental Health, and the results of this study have the potential to describe specific neurobiological mechanisms associated with excessive self-consciousness – a dimensional phenotype that cuts across anxiety and depressive disorders. Future work will aim to develop personalized treatments to target the neural mechanisms identified in this study in order to reduce distress and improve functional outcomes.

抽象的 人们越来越认识到，焦虑症和抑郁症等临床精神疾病之间存在严格的区别。 一方面，抑郁，以及更稳定地体验负面情绪（负面情绪） 另一方面，未能捕捉到精神病理学的真正本质。我们认为，通过检查 跨越抑郁症和焦虑症的特定维度表型，我们将能够更好地 识别与个体的痛苦特别相关的神经生物学过程 功能障碍——开发更有效、更有针对性的治疗方法的关键一步。负面情绪的影响范围很广 抑郁症和焦虑症的根源，并与巨大的公共卫生后果相关。 消极情感的一个具体方面，即过度的自我意识，可能代表了一种维度 表型与神经机制中的特定功能障碍模式密切相关，可导致 调节情绪反应的困难。过度的自我意识是指感到羞耻的倾向， 羞辱和不足。我们的初步数据表明，它与功能改变密切相关 在自我相关处理神经区域和负责情绪调节的区域中 急性精神症状。此外，我们的研究结果表明，过度的自我意识会强烈影响 与现实世界中特定类型的人际问题相关。该项目的主要目标是测试 与过度自我意识相关的情绪调节过程中神经功能障碍的新模型 并检查这种功能障碍对现实世界的影响。为了实现这些目标，125 名年轻人 至少有轻微抑郁或焦虑症状的（18-25岁）将被招募。此外，75 将招募人口统计匹配、精神健康的个体，以确保我们捕获完整的信息 所有感兴趣维度的范围。参与者将完成临床和神经影像评估， 以及 6 个月和 12 个月的后续评估，其中包括现实世界的为期一周的每日日记协议 发挥作用。该项目将检查1）过度的自我意识是否与异常有关 在自我相关的加工区域中发挥作用； 2）过度的自我意识是否与 情绪调节回路功能异常； 3）这些神经是否异常 系统前瞻性地预测精神症状以及较差的人际关系和工作功能 6 和 12 几个月后。该项目的目标与国家心理研究所的战略目标非常吻合 健康，这项研究的结果有可能描述特定的神经生物学机制 与过度的自我意识有关——一种跨越焦虑和焦虑的维度表型 抑郁症。未来的工作将致力于开发针对神经机制的个性化治疗方法 本研究中确定的目的是为了减少痛苦并改善功能结果。