Transdiagnostic Neural Mechanisms Underlying Dimensions of Negative Affectivity in Depression and Anxiety
抑郁和焦虑中消极情感维度的跨诊断神经机制
基本信息
- 批准号:10455635
- 负责人:
- 金额:$ 42.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-06-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAmygdaloid structureAngerAnteriorAnxietyAnxiety DisordersBrainClinicalConflict (Psychology)ConsciousDataDepressive disorderDimensionsDistressDorsalEmotionalEmotionsEnsureFunctional disorderFutureGoalsGrainHostilityImpairmentIndividualLeadMeasuresMental DepressionMental disordersModelingMood DisordersNational Institute of Mental HealthNatureNeurobiologyNeuronal DysfunctionOccupationalParticipantPatternPersonsPhenotypePrefrontal CortexProcessProductivityProtocols documentationPsychiatric DiagnosisPsychopathologyPublic HealthRegulationResearch Domain CriteriaRestSeveritiesShameSymptomsSystemTestingVisitWorkanxiety symptomsbasebrain dysfunctioncingulate cortexcognitive controldepressive symptomsdiariesemotion regulationemotional experienceexperiencefollow up assessmentfollow-upfunctional outcomeshumiliationimprovedindividualized medicineinterestnegative affectnetwork dysfunctionneural circuitneural modelneural patterningneurobiological mechanismneuroimagingneuroimaging markerneuromechanismnovelpersonalized medicineprospectivepsychiatric symptomrecruitrelating to nervous systemresponsesecondary analysisyoung adult
项目摘要
ABSTRACT
There is growing recognition that strict distinctions between clinical psychiatric disorders such as anxiety and
depression, on the one hand, and more stable dispositions to experience negative emotions (negative
affectivity), on the other, fail to capture the true nature of psychopathology. We argue that by examining
specific dimensional phenotypes that cut across depression and anxiety disorders, we will be better able to
identify the neurobiological processes that are specifically associated with an individual's distress and
dysfunction – a critical step for developing more effective, targeted treatments. Negative affectivity is a broad
dimension that underlies depression and anxiety and is associated with enormous public health consequences.
One of the specific facets of negative affectivity, excessive self-consciousness, may represent a dimensional
phenotype that is closely aligned with a specific pattern of dysfunction in neural mechanisms that can lead to
difficulties regulating emotional responses. Excessive self-consciousness refers to the tendency to feel shame,
humiliation, and inadequacy. Our preliminary data suggest that it is strongly associated with altered functioning
in self-related processing neural regions and in regions responsible for emotion regulation, over and above
acute psychiatric symptoms. Furthermore, our findings suggest that excessive self-consciousness is strongly
associated with specific types of real-world interpersonal problems. The primary goals of this project are to test
a novel model of neural dysfunction during emotion regulation associated with excessive self-consciousness
and to examine the real-world consequences of that dysfunction. To achieve these goals, 125 young adults
(18-25 years old) with at least mild symptoms of depression or anxiety will be recruited. In addition, 75
demographically matched, psychiatrically healthy individuals will be recruited to ensure that we capture the full
range for all of the dimensions of interest. Participants will complete clinical and neuroimaging assessments,
as well as 6- and 12-month follow-up assessments that will include weeklong daily diary protocols of real-world
functioning. The project will examine 1) whether excessive self-consciousness is associated with abnormal
functioning in self-related processing regions; 2) whether excessive self-consciousness is associated with
abnormalities in the functioning of the emotion regulation circuit; and 3) whether abnormalities in these neural
systems prospectively predict psychiatric symptoms and poorer interpersonal and work functioning 6 and 12
months later. The aims of the project match well with the strategic goals of the National Institute of Mental
Health, and the results of this study have the potential to describe specific neurobiological mechanisms
associated with excessive self-consciousness – a dimensional phenotype that cuts across anxiety and
depressive disorders. Future work will aim to develop personalized treatments to target the neural mechanisms
identified in this study in order to reduce distress and improve functional outcomes.
摘要
项目成果
期刊论文数量(0)
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Jay C Fournier其他文献
Jay C Fournier的其他文献
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{{ truncateString('Jay C Fournier', 18)}}的其他基金
Neural and Behavioral Mechanisms of Angry Hostility in Depression
抑郁症中愤怒敌意的神经和行为机制
- 批准号:
10744840 - 财政年份:2023
- 资助金额:
$ 42.28万 - 项目类别:
Bottom-Up Mechanisms of Dysfunctional Self Evaluation in Depression
抑郁症自我评价功能失调的自下而上机制
- 批准号:
10377165 - 财政年份:2021
- 资助金额:
$ 42.28万 - 项目类别:
Transdiagnostic Neural Mechanisms Underlying Dimensions of Negative Affectivity in Depression and Anxiety
抑郁和焦虑中消极情感维度的跨诊断神经机制
- 批准号:
10349731 - 财政年份:2018
- 资助金额:
$ 42.28万 - 项目类别:
Transdiagnostic Neural Mechanisms Underlying Dimensions of Negative Affectivity in Depression and Anxiety
抑郁和焦虑中消极情感维度的跨诊断神经机制
- 批准号:
9912199 - 财政年份:2018
- 资助金额:
$ 42.28万 - 项目类别:
Neural Markers of Individual Difference in Emotion Regulation in Depressed Adults
抑郁成人情绪调节个体差异的神经标志物
- 批准号:
8643292 - 财政年份:2013
- 资助金额:
$ 42.28万 - 项目类别:
Neural Markers of Individual Difference in Emotion Regulation in Depressed Adults
抑郁成人情绪调节个体差异的神经标志物
- 批准号:
8503117 - 财政年份:2013
- 资助金额:
$ 42.28万 - 项目类别:














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