Transdiagnostic Neural Mechanisms Underlying Dimensions of Negative Affectivity in Depression and Anxiety

抑郁和焦虑中消极情感维度的跨诊断神经机制

• 批准号: 10455635
• 负责人: Jay C Fournier
• 金额: $ 42.28万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10455635
• 关键词: Acute; Amygdaloid structure; Anger; Anterior; Anxiety; Anxiety Disorders; Brain; Clinical; Conflict (Psychology); Conscious; Data; Depressive disorder; Dimensions; Distress; Dorsal; Emotional; Emotions; Ensure; Functional disorder; Future; Goals; Grain; Hostility; Impairment; Individual; Lead; Measures; Mental Depression; Mental disorders; Modeling; Mood Disorders; National Institute of Mental Health; Nature; Neurobiology; Neuronal Dysfunction; Occupational; Participant; Pattern; Persons; Phenotype; Prefrontal Cortex; Process; Productivity; Protocols documentation; Psychiatric Diagnosis; Psychopathology; Public Health; Regulation; Research Domain Criteria; Rest; Severities; Shame; Symptoms; System; Testing; Visit; Work; anxiety symptoms; base; brain dysfunction; cingulate cortex; cognitive control; depressive symptoms; diaries; emotion regulation; emotional experience; experience; follow up assessment; follow-up; functional outcomes; humiliation; improved; individualized medicine; interest; negative affect; network dysfunction; neural circuit; neural model; neural patterning; neurobiological mechanism; neuroimaging; neuroimaging marker; neuromechanism; novel; personalized medicine; prospective; psychiatric symptom; recruit; relating to nervous system; response; secondary analysis; young adult

ABSTRACT There is growing recognition that strict distinctions between clinical psychiatric disorders such as anxiety and depression, on the one hand, and more stable dispositions to experience negative emotions (negative affectivity), on the other, fail to capture the true nature of psychopathology. We argue that by examining specific dimensional phenotypes that cut across depression and anxiety disorders, we will be better able to identify the neurobiological processes that are specifically associated with an individual's distress and dysfunction – a critical step for developing more effective, targeted treatments. Negative affectivity is a broad dimension that underlies depression and anxiety and is associated with enormous public health consequences. One of the specific facets of negative affectivity, excessive self-consciousness, may represent a dimensional phenotype that is closely aligned with a specific pattern of dysfunction in neural mechanisms that can lead to difficulties regulating emotional responses. Excessive self-consciousness refers to the tendency to feel shame, humiliation, and inadequacy. Our preliminary data suggest that it is strongly associated with altered functioning in self-related processing neural regions and in regions responsible for emotion regulation, over and above acute psychiatric symptoms. Furthermore, our findings suggest that excessive self-consciousness is strongly associated with specific types of real-world interpersonal problems. The primary goals of this project are to test a novel model of neural dysfunction during emotion regulation associated with excessive self-consciousness and to examine the real-world consequences of that dysfunction. To achieve these goals, 125 young adults (18-25 years old) with at least mild symptoms of depression or anxiety will be recruited. In addition, 75 demographically matched, psychiatrically healthy individuals will be recruited to ensure that we capture the full range for all of the dimensions of interest. Participants will complete clinical and neuroimaging assessments, as well as 6- and 12-month follow-up assessments that will include weeklong daily diary protocols of real-world functioning. The project will examine 1) whether excessive self-consciousness is associated with abnormal functioning in self-related processing regions; 2) whether excessive self-consciousness is associated with abnormalities in the functioning of the emotion regulation circuit; and 3) whether abnormalities in these neural systems prospectively predict psychiatric symptoms and poorer interpersonal and work functioning 6 and 12 months later. The aims of the project match well with the strategic goals of the National Institute of Mental Health, and the results of this study have the potential to describe specific neurobiological mechanisms associated with excessive self-consciousness – a dimensional phenotype that cuts across anxiety and depressive disorders. Future work will aim to develop personalized treatments to target the neural mechanisms identified in this study in order to reduce distress and improve functional outcomes.

摘要 越来越多的人认识到，临床精神疾病，如焦虑和焦虑， 抑郁症，一方面，和更稳定的倾向，体验负面情绪（负面 情感），另一方面，未能捕捉到精神病理学的真正本质。我们认为，通过检查 具体的维度表型跨越抑郁症和焦虑症，我们将能够更好地 识别与个体痛苦具体相关的神经生物学过程， 功能障碍-开发更有效，有针对性的治疗的关键一步。消极情感是一种广泛的 这是抑郁和焦虑的基础，并与巨大的公共卫生后果有关。 消极情感的一个具体方面，过度的自我意识，可能代表了一个维度， 表型与神经机制中的特定功能障碍模式密切相关， 难以调节情绪反应过度的自我意识是指感到羞耻的倾向， 羞辱和无能我们的初步数据表明，它与功能改变密切相关， 在自我相关的处理神经区域和负责情绪调节的区域， 急性精神症状此外，我们的研究结果表明，过度的自我意识是强烈的， 与特定类型的现实世界人际关系问题有关。本项目的主要目标是测试 一种与过度自我意识相关的情绪调节过程中神经功能障碍的新模型 并检查这种功能障碍在现实世界中的后果。为了实现这些目标，125名年轻人 （18-25岁），至少有轻度抑郁或焦虑症状。此外，75 将招募人口统计学上匹配的、精神健康的个体，以确保我们能充分捕捉到这些人。 所有感兴趣的维度的范围。参与者将完成临床和神经影像学评估， 以及6个月和12个月的随访评估，其中包括为期一周的真实世界每日日记方案。 功能该项目将研究1）过度的自我意识是否与异常 在自我相关的处理区域运作; 2）过度的自我意识是否与 情绪调节回路的功能异常;以及3）这些神经元中的异常是否 系统前瞻性地预测精神症状和较差的人际和工作功能6和12 月后该项目的目标与国家心理研究所的战略目标非常吻合， 健康，而这项研究的结果有可能描述特定的神经生物学机制 与过度的自我意识相关--一种跨越焦虑和焦虑的维度表型 抑郁症未来的工作将旨在开发针对神经机制的个性化治疗方法 在这项研究中确定，以减少痛苦和改善功能的结果。