2020 Basal Ganglia Gordon Research Conference and Gordon Research Seminar

项目摘要/摘要： 基底节是一组错综复杂的皮质下脑区，它们对 行动的动机、选择、发起和执行。与这些角色一致的是，基底节功能障碍 与衰弱的精神运动障碍有关，包括帕金森氏症，亨廷顿病，肌张力障碍， 成瘾、强迫症和抽动症。基底神经节在脑内的重要性 健康与疾病，以及探索其作用的方法的不断发展和演变 和互动，激励了专注于这些结构的不同研究社区。尽管不断增长 对基底节研究的兴趣，在年首届基底节戈登研究会议(GRC)之前 2014年，唯一一次关注基底节的会议是国际基底节三年一次的会议 神经节协会(IBags)，通常在美国境外举行。此外，iBags会议遵循典型的 专题讨论会形式，这与GRC的交互式、以讨论为导向的形式形成了鲜明对比。自.以来 2016年，基底节GRC纳入了为期1.5天的戈登研究研讨会(GRS) 专供博士后和博士后实习生使用。从2018年基本神经节GRC&GRS开始， 这些会议现在是定期的两年一次的会议。2020年基底神经节GRC和GRS的计划是 由代表该领域基础和临床研究的跨学科委员会设计。深思熟虑 努力纳入2018年会议没有包括的新发言者和议题， 基本神经节：从思想到行动。主题包括认知和决策， 基底节的细胞可塑性，基底节回路内外的相互作用，新的计算 模型，以及与临床相关的步态冻结。 2020基底节GRC和GRS有3个具体目标：1)通过以下方式推进基底节研究 在鼓励提问和讨论的互动环境中展示尖端研究， 挑战当前思维，发现有待解决的问题，并提供新的协作机会；2)模式 基底节研究在科学方法和主题、性别平衡、职业阶段、 和少数族裔代表；以及3)为早期儿童提供领导、教育和指导的机会 职业科学家。这些目标的成功完成将通过鼓励 新的想法和合作，突出该领域的多样性，并激励下一代科学家。 这应该会加快发现并转化为临床的步伐，这与NIH的使命一致。

Project Summary/Abstract: The basal ganglia are an intricately interconnected group of subcortical brain regions that are critical for the motivation, selection, initiation, and execution of actions. Consistent with these roles, basal ganglia dysfunction is linked to debilitating psychomotor disorders, including Parkinson’s disease, Huntington’s disease, dystonia, addiction, obsessive compulsive disorder, and Tourette’s syndrome. The importance of the basal ganglia in health and disease, together with the on-going development and evolution of approaches to probe their roles and interactions, have motivated diverse research communities focused on these structures. Despite growing interest in basal ganglia research, before the inaugural Basal Ganglia Gordon Research Conference (GRC) in 2014, the only conference focused on the basal ganglia was the triennial meeting of the International Basal Ganglia Society (IBAGS), which is usually held outside the USA. Moreover, IBAGS meetings follow a typical symposium format, which contrasts markedly with the interactive, discussion-oriented format of a GRC. Since 2016, the Basal Ganglia GRC has incorporated a 1.5 day Gordon Research Seminar (GRS) organized exclusively by and for pre- and post-doctoral trainees. Beginning with the 2018 Basal Ganglia GRC & GRS, these are now regular biennial meetings. The programs for the 2020 Basal Ganglia GRC & GRS were designed by an interdisciplinary committee representing basic and clinical research in the field. A deliberate effort was made to include new speakers and topics that were not included in the 2018 meeting, with the overarching theme Basal Ganglia: From Thought to Action. Topics include cognition and decision making, cellular plasticity in the basal ganglia, interactions within and beyond basal ganglia circuits, new computational models, and clinically relevant freezing of gait. The 2020 Basal Ganglia GRC and GRS have 3 specific aims: 1) move basal ganglia research forward by featuring cutting-edge research in an interactive environment that encourages questions and discussion, challenges current thinking, identifies open questions, and provides opportunities new collaborations; 2) model diversity in basal ganglia research with respect to scientific approach and topics, gender balance, career stage, and minority representation; and 3) provide opportunities for leadership, education, and mentoring for early career scientists. Successful completion of these aims will advance basal ganglia research by encouraging new ideas and collaborations, highlighting diversity in the field, and inspiring the next generation of scientists. This should accelerate the pace of discovery and translation to the clinic, consistent with the mission of NIH.