Training Program in Molecular Hematology

项目概要 血液学的基础和转化研究一直处于我们最新进展的前沿。 几十年来对疾病的分子病理生理学的了解。我们请求的 T32 补助金 更新，于 5 年前提交，以取代原哈佛医学院培训计划 分子血液学在研究生培养方面拥有 25 年的杰出记录， 研究血液及其疾病的博士后研究员，该项目的许多毕业生继续 非常成功的学术生涯。过去30年，面貌发生了许多变化 哈佛医学领域的血液学-肿瘤学，以及哈佛医学院血液学项目的合并 布莱根妇女医院与马萨诸塞州总医院和马萨诸塞州总医院的肿瘤学项目 丹娜—法伯癌症研究所成立血液学-肿瘤学联合奖学金。这对我国产生了很多积极的影响 临床和研究培训的机会，并辅之以大量的培训项目。在 与此同时，新技术的爆炸式增长开创了生物医学研究的时代，提供了令人兴奋的成果 我们对人类疾病的理解有重大突破的机会，为新的临床研究带来希望 可以改变许多血液疾病治疗的范例。然而，失去了一个专门的 血液学研究金让我们敏锐地意识到培养医师科学家的重要性 致力于血液学研究。事实上，独立的血液学奖学金的消失 全国范围内血液学实习生数量的减少表明迫切需要鼓励未来 学术血液学家。该计划高度重视培训医师科学家，重点关注 血液学，我们很高兴看到越来越多的临床研究员选择从事血液学 作为这项补助金的实习生进行研究。迄今为止，我们已为所有医学博士和医学博士/博士研究员提供了住宿 研究重点是血液学，尽管我们有适当的选择过程，但我们是否必须限制 由于感兴趣的研究员的增加而变得可用。这个过程已经在前两个中使用过 多年的资助选择博士研究员来填补可用的空缺，尽管所有后续空缺都已被 医师科学家。培训的主要地点是导师的实验室，但每个受训者都应该 参加 HMS 社区内的相关研讨会和课程。每个学员还组装了一个 培训委员会通过年度正式演示来监督研究进展。我们强烈鼓励 红细胞疾病、铁代谢、 止血和血栓形成，中性粒细胞疾病，以及血液恶性肿瘤，例如白血病， 骨髓增生异常和骨髓增生性肿瘤。这种对血液学的严格关注使这项资助与众不同 来自其他哈佛相关培训补助金，满足任何其他培训补助金无法满足的需求 在成人医学范围内。我们请求更新此申请及其当前 8 个培训职位。！

Project Summary Basic and translational research in hematology has been at the cutting edge of recent advances in our understanding of the molecular pathophysiology of disease for decades. This T32 grant, for which we request renewal, was submitted 5 years ago to replace the former Harvard Medical School Training Program in Molecular Hematology, which had a distinguished 25-year track record in training graduate students and postdoctoral fellows in the study of blood and its disorders, with many graduates of the program going on to highly successful academic careers. The past 30 years have seen many changes in the landscape of hematology-oncology in the Harvard Medical area, with the merging of the Hematology program at the Brigham and Women’s Hospital with the oncology programs at the Massachusetts General Hospital and the Dana-Farber to form a combined Hematology-Oncology fellowship. This has had many positive effects on the opportunities for clinical and research training, complemented by a proliferation of training programs. At the same time, an explosion of new technologies has ushered in an era in biomedical research that offers exciting opportunities for major breakthroughs in our understanding of human disease, offering hope for new clinical paradigms that can transform the treatment of many hematologic disorders. However, the loss of a dedicated Hematology fellowship has made us acutely aware of the importance of nurturing physician scientists dedicated to the study of hematology. Indeed, the disappearance of free-standing hematology fellowships nationwide and the shrinking numbers of Hematology trainees signals an urgent need to encourage future academic hematologists. This program places high priority on training physician-scientists focused on hematology, and we have been gratified to see an increasing number of clinical fellows who choose to do research as trainees on this grant. To date, we have accommodated all the MD and MD/PhD fellows with a research focus on Hematology, although we have a selection process in place should we have to limit availability because of an increase in interested fellows. This process has already been used in the first two years of the grant to select PhD fellows to fill available slots, although all subsequent slots have been taken by physician scientists. The primary site of training is the preceptor’s laboratory, but each trainee is expected to participate in relevant seminars and courses within the HMS community. Each trainee also assembles a training committee that monitors research progress with annual formal presentations. We strongly encourage the investigation of benign hematologic disorders in the areas of red cell disorders, iron metabolism, hemostasis and thrombosis, and neutrophil disorders, as well as hematologic malignancies such as leukemia, myelodysplasia, and myeloproliferative neoplasms. This strict focus on Hematology distinguishes this grant from other Harvard-related training grants, fulfilling a need that is not answered by any other training grant within adult medicine. We request renewal of this application with its 8 current training positions.!