Training Program in Molecular Hematology

描述（由申请人提供）：血液学的基础和转化研究一直处于我们对疾病分子病理生理学理解的最新进展的前沿。前哈佛医学院的分子血液学培训项目在培训研究生和博士后研究员研究血液及其疾病方面有着25年的杰出记录，该项目的许多毕业生都在学术生涯中取得了非常成功。在过去的25年里，哈佛医学领域的血液肿瘤学景观发生了许多变化，布里格姆妇女医院的血液学项目与马萨诸塞州总医院和达纳法伯的肿瘤学项目合并，形成了一个联合的血液肿瘤学奖学金。这对临床和研究培训的机会产生了许多积极影响，并辅之以培训方案的激增。与此同时，新技术的爆炸式发展开创了生物医学研究的新时代，为我们对人类疾病的理解取得重大突破提供了令人兴奋的机会，为能够改变许多血液疾病治疗的新临床范式带来了希望。然而，一个专门的血液学奖学金的损失使我们敏锐地意识到培养致力于血液学研究的医生科学家的重要性。事实上，全国范围内独立的血液学奖学金的消失和血液学实习生人数的减少表明迫切需要鼓励未来的学术血液学家。因此，在这个新的应用中，我们寻求通过新配置的教师和更明确的重点来扩展以前血液学培训计划的成功。该计划将仅限于博士后职位，选拔过程将高度重视培养医生-专注于血液学的科学家。潜在的候选人将由潜在的导师或项目负责人提名，申请将由指导委员会审查。最后的任命将由项目主任作出。培训的主要地点将是导师的实验室，但每个受训者都将参加HMS社区内的相关研讨会和课程。每个受训者还将组建一个培训委员会，通过年度正式报告监测研究进展。我们将大力鼓励对红细胞疾病、铁代谢、止血和血栓形成、中性粒细胞疾病等领域的良性血液系统疾病以及白血病、骨髓增生异常和骨髓增生性肿瘤等血液系统恶性肿瘤进行研究。对血液学的严格关注将使该补助金与其他哈佛相关的培训赠款区分开来，满足成人医学中任何其他培训补助金都无法满足的需求。(End摘要）

DESCRIPTION (provided by applicant): Basic and translational research in hematology has been at the cutting edge of recent advances in our understanding of the molecular pathophysiology of disease. The former Harvard Medical School Training Program in Molecular Hematology had a distinguished 25-year track record in training graduate students and postdoctoral fellows in the study of blood and its disorders, with many graduates of the program going on to highly successful academic careers. The past 25 years have seen many changes in the landscape of hematology-oncology in the Harvard Medical area, with the merging of the Hematology program at the Brigham and Women's Hospital with the oncology programs at the Massachusetts General Hospital and the Dana-Farber to form a combined Hematology-Oncology fellowship. This has had many positive effects on the opportunities for clinical and research training, complemented by a proliferation of training programs. At the same time, an explosion of new technologies has ushered in an era in biomedical research that offers exciting opportunities for major breakthroughs in our understanding of human disease, offering hope for new clinical paradigms that can transform the treatment of many hematologic disorders. However, the loss of a dedicated Hematology fellowship has made us acutely aware of the importance of nurturing physician scientists dedicated to the study of hematology. Indeed, the disappearance of free-standing hematology fellowships nationwide and the shrinking numbers of Hematology trainees signals an urgent need to encourage future academic hematologists. Therefore, in this new application, we seek to extend the success of the previous Hematology training program through a newly configured faculty and a more defined focus. The program will be limited to postdoctoral positions, and the selection process will place high priority on trainin physician- scientists focused on hematology. Potential candidates will be nominated by a potential preceptor or program leader, and applications will be reviewed by a Steering Committee. Final appointments will be made by the Program Directors. The primary site of training will be the preceptor's laboratory, but each trainee will be expected to participate in relevant seminars and courses within the HMS community. Each trainee will also assemble a training committee that will monitor research progress with annual formal presentations. We will strongly encourage the investigation of benign hematologic disorders in the areas of red cell disorders, iron metabolism, hemostasis and thrombosis, and neutrophil disorders, as well as hematologic malignancies such as leukemia, myelodysplasia, and myeloproliferative neoplasms. This strict focus on Hematology will distinguish this grant from other Harvard-related training grants, fulfilling a need that is not answered by any other training grant within adult medicine. (End of Abstract)