Training Program in Molecular Hematology

描述(由申请人提供)：血液学的基础和翻译研究一直处于我们对疾病的分子病理生理学理解的最新进展的前沿。前哈佛医学院分子血液学培训项目在培训研究生和博士后研究血液及其疾病方面有着25年的卓越记录，该项目的许多毕业生后来在学术生涯中取得了非常成功的成就。在过去的25年里，随着布里格姆妇女医院的血液学项目与马萨诸塞州综合医院和达纳-法伯医院的肿瘤学项目的合并，哈佛医学区的血液肿瘤学领域发生了许多变化，形成了血液学和肿瘤学的联合奖学金。这对临床和研究培训的机会产生了许多积极影响，并辅之以培训计划的激增。与此同时，新技术的爆炸性增长开启了生物医学研究的时代，为我们对人类疾病的理解取得重大突破提供了令人兴奋的机会，为能够改变许多血液疾病治疗的新临床范式带来了希望。然而，失去专门的血液学奖学金使我们敏锐地意识到培养致力于血液学研究的内科科学家的重要性。事实上，全国范围内独立的血液学奖学金的消失和血液学实习生数量的减少表明，迫切需要鼓励未来的学术血液学家。因此，在这一新的应用中，我们寻求通过新配置的教员和更明确的重点来扩展先前血液学培训计划的成功。该计划将仅限于博士后职位，遴选过程将高度优先考虑专注于血液学的内科科学家的培训。潜在的候选人将由潜在的教官或项目负责人提名，申请将由指导委员会审查。最终任命将由项目主管做出。培训的主要地点将是教官的实验室，但每个受训人员将被要求参加HMS社区内的相关研讨会和课程。每个学员还将组建一个培训委员会，该委员会将通过年度正式报告来监督研究进展。大力鼓励开展红细胞疾病、铁代谢、止血血栓、中性粒细胞疾病等良性血液病以及白血病、骨髓增生异常、骨髓增生性肿瘤等恶性血液病的调查。这种对血液学的严格关注将把这笔拨款与其他与哈佛相关的培训拨款区分开来，满足成人医学领域其他任何培训拨款无法满足的需求。(摘要结束)

DESCRIPTION (provided by applicant): Basic and translational research in hematology has been at the cutting edge of recent advances in our understanding of the molecular pathophysiology of disease. The former Harvard Medical School Training Program in Molecular Hematology had a distinguished 25-year track record in training graduate students and postdoctoral fellows in the study of blood and its disorders, with many graduates of the program going on to highly successful academic careers. The past 25 years have seen many changes in the landscape of hematology-oncology in the Harvard Medical area, with the merging of the Hematology program at the Brigham and Women's Hospital with the oncology programs at the Massachusetts General Hospital and the Dana-Farber to form a combined Hematology-Oncology fellowship. This has had many positive effects on the opportunities for clinical and research training, complemented by a proliferation of training programs. At the same time, an explosion of new technologies has ushered in an era in biomedical research that offers exciting opportunities for major breakthroughs in our understanding of human disease, offering hope for new clinical paradigms that can transform the treatment of many hematologic disorders. However, the loss of a dedicated Hematology fellowship has made us acutely aware of the importance of nurturing physician scientists dedicated to the study of hematology. Indeed, the disappearance of free-standing hematology fellowships nationwide and the shrinking numbers of Hematology trainees signals an urgent need to encourage future academic hematologists. Therefore, in this new application, we seek to extend the success of the previous Hematology training program through a newly configured faculty and a more defined focus. The program will be limited to postdoctoral positions, and the selection process will place high priority on trainin physician- scientists focused on hematology. Potential candidates will be nominated by a potential preceptor or program leader, and applications will be reviewed by a Steering Committee. Final appointments will be made by the Program Directors. The primary site of training will be the preceptor's laboratory, but each trainee will be expected to participate in relevant seminars and courses within the HMS community. Each trainee will also assemble a training committee that will monitor research progress with annual formal presentations. We will strongly encourage the investigation of benign hematologic disorders in the areas of red cell disorders, iron metabolism, hemostasis and thrombosis, and neutrophil disorders, as well as hematologic malignancies such as leukemia, myelodysplasia, and myeloproliferative neoplasms. This strict focus on Hematology will distinguish this grant from other Harvard-related training grants, fulfilling a need that is not answered by any other training grant within adult medicine. (End of Abstract)