Training Program in Molecular Hematology

分子血液学培训计划

• 批准号: 10456270
• 负责人: NANCY BERLINER
• 金额: $ 68.57万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456270
• 关键词: Training Programs; molecular hematology

Project Summary Basic and translational research in hematology has been at the cutting edge of recent advances in our understanding of the molecular pathophysiology of disease for decades. This T32 grant, for which we request renewal, was submitted 5 years ago to replace the former Harvard Medical School Training Program in Molecular Hematology, which had a distinguished 25-year track record in training graduate students and postdoctoral fellows in the study of blood and its disorders, with many graduates of the program going on to highly successful academic careers. The past 30 years have seen many changes in the landscape of hematology-oncology in the Harvard Medical area, with the merging of the Hematology program at the Brigham and Women’s Hospital with the oncology programs at the Massachusetts General Hospital and the Dana-Farber to form a combined Hematology-Oncology fellowship. This has had many positive effects on the opportunities for clinical and research training, complemented by a proliferation of training programs. At the same time, an explosion of new technologies has ushered in an era in biomedical research that offers exciting opportunities for major breakthroughs in our understanding of human disease, offering hope for new clinical paradigms that can transform the treatment of many hematologic disorders. However, the loss of a dedicated Hematology fellowship has made us acutely aware of the importance of nurturing physician scientists dedicated to the study of hematology. Indeed, the disappearance of free-standing hematology fellowships nationwide and the shrinking numbers of Hematology trainees signals an urgent need to encourage future academic hematologists. This program places high priority on training physician-scientists focused on hematology, and we have been gratified to see an increasing number of clinical fellows who choose to do research as trainees on this grant. To date, we have accommodated all the MD and MD/PhD fellows with a research focus on Hematology, although we have a selection process in place should we have to limit availability because of an increase in interested fellows. This process has already been used in the first two years of the grant to select PhD fellows to fill available slots, although all subsequent slots have been taken by physician scientists. The primary site of training is the preceptor’s laboratory, but each trainee is expected to participate in relevant seminars and courses within the HMS community. Each trainee also assembles a training committee that monitors research progress with annual formal presentations. We strongly encourage the investigation of benign hematologic disorders in the areas of red cell disorders, iron metabolism, hemostasis and thrombosis, and neutrophil disorders, as well as hematologic malignancies such as leukemia, myelodysplasia, and myeloproliferative neoplasms. This strict focus on Hematology distinguishes this grant from other Harvard-related training grants, fulfilling a need that is not answered by any other training grant within adult medicine. We request renewal of this application with its 8 current training positions.!

项目摘要 血液学的基础和翻译研究一直处于我们的最新进展的前沿 几十年来对疾病的分子病理生理学的了解。这项T32拨款，我们要求 续签，5年前提交，以取代前哈佛医学院培训计划 分子血液学，在培养研究生和 血液及其疾病研究的博士后研究员，该项目的许多毕业生将继续 非常成功的学术生涯。在过去的30年里，发生了许多变化 血液学-肿瘤学在哈佛医学区，与血液学计划在 布里格姆妇女医院和马萨诸塞州总医院的肿瘤学项目 Dana-Farber成立血液学和肿瘤学联合奖学金。这对中国的经济发展产生了许多积极影响 临床和研究培训的机会，并辅之以培训项目的激增。在 与此同时，新技术的爆炸性增长开启了生物医学研究的时代，它提供了令人兴奋的 我们对人类疾病的认识有重大突破的机会，为新的临床提供了希望 可以改变许多血液病治疗的范例。然而，失去了一位敬业的 血液学研究使我们敏锐地意识到培养内科科学家的重要性。 致力于血液学研究。事实上，独立的血液学奖学金的消失 全国范围内血液学实习生人数的减少表明迫切需要鼓励未来 学术血液学家。该计划高度重视培养专注于以下领域的医生-科学家 血液学，我们很高兴看到越来越多的临床研究员选择 作为这笔拨款的实习生进行研究。到目前为止，我们已经为所有的医学博士和医学博士研究员提供了 研究的重点是血液学，尽管我们有一个适当的选择程序，如果我们必须限制 由于感兴趣的研究员增加，因此有更多的人可用。这个过程已经在前两个版本中使用过 为挑选博士研究员填补空缺提供了数年的赠款，尽管随后的所有空缺都已由 内科科学家。培训的主要地点是教官的实验室，但每个受训者都应该 参加HMS社区内的相关研讨会和课程。每个实习生还组装了一个 通过年度正式报告来监督研究进展的培训委员会。我们强烈鼓励 良性血液疾病的研究领域包括红细胞紊乱、铁代谢、 止血和血栓形成，中性粒细胞紊乱，以及白血病等血液系统恶性肿瘤， 骨髓发育不良和骨髓增生性肿瘤。这种对血液学的严格关注使这笔赠款与众不同 来自其他与哈佛相关的培训补助金，满足了任何其他培训补助金无法满足的需求 在成人医学范围内。我们要求续签这份申请，目前有8个培训职位。