Training Program in Molecular Hematology

分子血液学培训计划

• 批准号: 10223402
• 负责人: NANCY BERLINER
• 金额: $ 63.07万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10223402
• 关键词: Training Programs; molecular hematology

Project Summary Basic and translational research in hematology has been at the cutting edge of recent advances in our understanding of the molecular pathophysiology of disease for decades. This T32 grant, for which we request renewal, was submitted 5 years ago to replace the former Harvard Medical School Training Program in Molecular Hematology, which had a distinguished 25-year track record in training graduate students and postdoctoral fellows in the study of blood and its disorders, with many graduates of the program going on to highly successful academic careers. The past 30 years have seen many changes in the landscape of hematology-oncology in the Harvard Medical area, with the merging of the Hematology program at the Brigham and Women’s Hospital with the oncology programs at the Massachusetts General Hospital and the Dana-Farber to form a combined Hematology-Oncology fellowship. This has had many positive effects on the opportunities for clinical and research training, complemented by a proliferation of training programs. At the same time, an explosion of new technologies has ushered in an era in biomedical research that offers exciting opportunities for major breakthroughs in our understanding of human disease, offering hope for new clinical paradigms that can transform the treatment of many hematologic disorders. However, the loss of a dedicated Hematology fellowship has made us acutely aware of the importance of nurturing physician scientists dedicated to the study of hematology. Indeed, the disappearance of free-standing hematology fellowships nationwide and the shrinking numbers of Hematology trainees signals an urgent need to encourage future academic hematologists. This program places high priority on training physician-scientists focused on hematology, and we have been gratified to see an increasing number of clinical fellows who choose to do research as trainees on this grant. To date, we have accommodated all the MD and MD/PhD fellows with a research focus on Hematology, although we have a selection process in place should we have to limit availability because of an increase in interested fellows. This process has already been used in the first two years of the grant to select PhD fellows to fill available slots, although all subsequent slots have been taken by physician scientists. The primary site of training is the preceptor’s laboratory, but each trainee is expected to participate in relevant seminars and courses within the HMS community. Each trainee also assembles a training committee that monitors research progress with annual formal presentations. We strongly encourage the investigation of benign hematologic disorders in the areas of red cell disorders, iron metabolism, hemostasis and thrombosis, and neutrophil disorders, as well as hematologic malignancies such as leukemia, myelodysplasia, and myeloproliferative neoplasms. This strict focus on Hematology distinguishes this grant from other Harvard-related training grants, fulfilling a need that is not answered by any other training grant within adult medicine. We request renewal of this application with its 8 current training positions.!

项目摘要 血液学的基础和转化研究一直处于我们国家最新进展的前沿。 对疾病的分子病理生理学的理解。我们申请的T32补助金 更新，5年前提交，以取代前哈佛医学院培训计划， 分子血液学在培养研究生方面有着25年的杰出记录， 博士后研究员在血液及其疾病的研究，与该计划的许多毕业生去 非常成功的学术生涯。在过去的30年里， 血液肿瘤学在哈佛医学领域，与血液学计划在合并， 布里格姆妇女医院与马萨诸塞州总医院和 Dana-Farber成立联合血液学-肿瘤学奖学金。这对我们的生活产生了许多积极的影响。 临床和研究培训的机会，辅以培训计划的扩散。在 与此同时，新技术的爆炸式发展也开创了生物医学研究的新时代， 在我们对人类疾病的理解方面取得重大突破的机会，为新的临床研究提供了希望。 可以改变许多血液疾病的治疗模式。然而，失去了一位敬业的 血液学奖学金使我们敏锐地意识到培养医生科学家的重要性 致力于血液学的研究事实上，独立的血液学奖学金的消失 在全国范围内，血液学学员人数的减少表明迫切需要鼓励未来 学术血液学家该计划高度重视培养医生-科学家，重点是 血液学，我们很高兴看到越来越多的临床研究员选择做 作为实习生进行研究。到目前为止，我们已经为所有的MD和MD/PhD研究员提供了 研究重点是血液学，虽然我们有一个适当的选择过程，我们应该限制 由于感兴趣的研究员人数增加，这个过程已经在前两个中使用 多年的赠款，以选择博士研究员，以填补可用的插槽，虽然所有随后的插槽已采取由 医学科学家培训的主要地点是导师的实验室，但每个学员都应 参加HMS社区内的相关研讨会和课程。每个学员还组装一个 培训委员会，通过年度正式报告监测研究进展。我们强烈鼓励 在红细胞疾病，铁代谢， 止血和血栓形成，和嗜中性粒细胞疾病，以及血液恶性肿瘤如白血病， 骨髓增生异常和骨髓增生性肿瘤。这种对血液学的严格关注使这项资助 来自其他哈佛相关的培训赠款，满足任何其他培训补助金都无法满足的需求 在成人医学中。我们要求更新此应用程序与其8个当前的培训职位。