California NeuroAIDS Tissue Network

这是加州神经艾滋病组织网络(CNTN)响应RFA-MH-18的续签申请- 250.CNTN是国家神经艾滋病组织联盟(NNTC)的积极参与者，NNTC是一个由四人组成的伙伴关系 美国国立卫生研究院资助的神经艾滋病组织库。CNTN的总体目标今天仍然与它相同 它是在1998年成立的，包括招募、临床评估和跟踪- 建立晚期艾滋病毒队列，以及2)收集、维护和分发样本给调查人员 有兴趣研究HIV诱导的中枢和外周神经的神经发病机制 系统功能障碍。 对于当前的应用，并为实现这些目标，CNTN将继续保持生活中的 至少150名参与者(主要是艾滋病毒/艾滋病患者，PLWHA)，目的是进行尸检 来自与《框架协议》三个主题优先事项相一致的高优先病例：a)从 中枢神经系统储存库；b)长期环境下HIV相关神经认知障碍(HAND)的机制 HAART，以及c)了解与艾滋病毒有关的共病，包括老龄化和慢性疾病的影响 艾滋病毒感染。CNTN将积累和管理活体(血浆、脑脊液、血液、粪便)和尸检数据库 (脑、心、肺、肝、肾、淋巴结、血液和脑脊液)样本和来自一群人的数据 艾滋病毒携带者在神经心理学、神经医学和精神病学方面都有很好的特征。CNTN将 另外收集用于新兴中枢神经系统治疗和根除研究的组织(例如，肠道淋巴组织、睾丸)， 和用于微生物组研究的粪便。CNTN在NNTC中是独一无二的，它承担了CNS的责任 HIV-1抗逆转录病毒治疗效果研究(CHECT)样本，包括血浆、脑脊液、口腔拭子、 皮肤活组织检查和核酸检测。未识别的宪章数据集(临床、实验室、遗传、神经成像、 和研究)已经转移到NNTC数据协调中心(DCC)，它们现在就在那里 维护好了。CNTN将严格保持CNTN和包机标本资源的质量 保证和质量控制程序，并将及时将数据和样本库存转移到 NNTC数据协调中心(DCC)。外部请求未确认的CNTN或包机数据，或 标本现在由DCC与NNTC站点合作管理，CNTN团队很好 根据NNTC的数据，提供CNTN和包机样本的及时分发 资源分配策略。最后，CNTN将继续作为NNTC的积极合作成员 通过：与DCC和其他NNTC站点协调；向更广泛的人提供科学和技术专业知识 作为NNTC指导委员会(SC)的投票成员，研究界审查以下请求 促进神经艾滋病研究的数据和样本；作为NNTC的领导者 神经心理学/精神病学小组委员会。 通过实现这些目标，CNTN将继续成为一个国家和国际组织 服务于神经艾滋病研究人员需求的资源。

This is a renewal application for the California NeuroAIDS Tissue Network (CNTN) in response to RFA-MH-18- 250. CNTN is an active participant in the National NeuroAIDS Tissue Consortium (NNTC), a partnership of four NIH-funded neuroAIDS tissue banks. The overarching objectives of the CNTN remains the same today as it was when it was first established in 1998 and encompass the 1) recruitment, clinical assessment, and follow- up of a late-stage HIV cohort, and 2) collection, maintenance, and distribution of specimens to investigators interested in conducting research on the neuropathogenesis of HIV-induced central and peripheral nervous system dysfunction. For the current application, and to address these objectives, CNTN will continue to maintain an in-life cohort of at least 150 participants (mostly people living with HIV/AIDS, PLWHA) with the purpose of obtaining autopsies from high priority cases that are aligned with the three thematic priorities in the RFA: a) HIV eradication from CNS reservoirs; b) mechanisms of HIV-associated neurocognitive disorders (HAND) in the setting of long-term HAART, and c) understanding comorbidities associated with HIV, including the effects of aging and chronic HIV-infection. CNTN will accumulate and manage a bank of in-life (plasma, CSF, blood, stool) and autopsy (brain, heart, lung, liver, kidney, lymph node, blood, and CSF) specimens and data from a cohort of persons living with HIV who are well characterized neuropsychologically, neuromedically, and psychiatrically. CNTN will additionally collect tissues (e.g., gut lymphoid tissue, testes) for emerging CNS cure and eradication research, and stool for microbiome research. Unique within the NNTC, the CNTN has assumed responsibility for CNS HIV-1 Antiretroviral Therapy Effects Research (CHARTER) specimens including plasma, CSF, buccal swabs, skin biopsies, and nucleic acids. De-identified CHARTER data sets (clinical, laboratory, genetic, neuroimaging, and research) have been transferred to the NNTC Data Coordinating Center (DCC), where they are now maintained. CNTN will maintain both the CNTN and CHARTER specimen resource abiding by strict quality assurance and quality control procedures, and will provide timely transfer of data and specimen inventories to the NNTC Data Coordinating Center (DCC). External requests for de-identified CNTN or CHARTER data or specimens are now managed by the DCC in collaboration with NNTC sites, and the CNTN team is well equipped to provide timely distribution of both CNTN and CHARTER specimens according to NNTC data and resource distribution policies. Finally, CNTN will continue to be an active collaborating member of the NNTC by: coordinating with the DCC and other NNTC sites; providing scientific and technical expertise to the wider research community as a voting member of the NNTC Steering Committee (SC), which reviews requests for data and specimens to facilitate neuroAIDS research; and as the leader of the NNTC Neuropsychology/Psychiatry subcommittee. Through the accomplishment of these objectives, the CNTN will continue to be a national and international resource serving the needs of neuroAIDS investigators.