California NeuroAIDS Tissue Network

这是加州神经艾滋病组织网络（CNTN）的更新申请，以响应RFA-MH-18- 250. CNTN是国家神经艾滋病组织联盟（NNTC）的积极参与者，该联盟由四个 NIH资助的神经艾滋病组织库。时至今日，CNTN的总体目标仍然与它相同 它于1998年首次成立，包括1）招募，临床评估，并遵循- 晚期HIV队列的最高水平，以及2）收集、维护和向研究者分发标本 对HIV引起的中枢和外周神经系统疾病的神经发病机制进行研究 系统功能障碍 对于当前的申请，为了实现这些目标，CNTN将继续维持一个活体队列， 至少150名参与者（主要是艾滋病毒/艾滋病感染者），目的是进行尸检 从符合《外地住房规划》三个优先主题的高度优先案例中： CNS储库; B）在长期治疗背景下HIV相关神经认知障碍（HAND）的机制 HAART，以及c）了解与HIV相关的合并症，包括衰老和慢性 艾滋病毒感染。CNTN将积累和管理活体（血浆、CSF、血液、粪便）和尸检样本库 （脑、心脏、肺、肝、肾、淋巴结、血液和CSF）样本和来自人群的数据 在神经心理学、神经医学和精神病学上具有良好特征的艾滋病毒感染者。CNTN将 另外收集组织（例如，肠淋巴组织，睾丸）用于新兴的CNS治愈和根除研究， 和粪便用于微生物组研究。在国家核技术委员会中，国家核技术委员会是独一无二的， HIV-1抗逆转录病毒治疗效果研究（CHARTER）标本，包括血浆、CSF、口腔拭子， 皮肤活检和核酸检测去识别化的CHARTER数据集（临床、实验室、遗传、神经成像， 和研究）已被转移到NNTC数据协调中心（DCC），他们现在 树立政治意识CNTN将以严格的质量标准维护CNTN和CHARTER标本资源 保证和质量控制程序，并将提供及时的数据和样本库存转移， NNTC数据协调中心（DCC）。外部请求去识别CNTN或CHARTER数据，或 标本现在由DCC与NNTC站点合作管理，CNTN团队很好地 根据国家核技术委员会的数据，及时分发CNTN和CHARTER标本， 资源分配政策。最后，CNTN将继续是NNTC的积极合作成员 通过：与DCC和其他NNTC站点协调;向更广泛的 研究界作为NNTC指导委员会（SC）的投票成员，该委员会负责审查 数据和标本，以促进神经艾滋病的研究;并作为领导人的国家结核病控制中心 神经心理学/精神病学小组委员会。 通过实现这些目标，国家电视台将继续成为国家和国际电视台。 资源服务neuroAIDS调查人员的需求。

This is a renewal application for the California NeuroAIDS Tissue Network (CNTN) in response to RFA-MH-18- 250. CNTN is an active participant in the National NeuroAIDS Tissue Consortium (NNTC), a partnership of four NIH-funded neuroAIDS tissue banks. The overarching objectives of the CNTN remains the same today as it was when it was first established in 1998 and encompass the 1) recruitment, clinical assessment, and follow- up of a late-stage HIV cohort, and 2) collection, maintenance, and distribution of specimens to investigators interested in conducting research on the neuropathogenesis of HIV-induced central and peripheral nervous system dysfunction. For the current application, and to address these objectives, CNTN will continue to maintain an in-life cohort of at least 150 participants (mostly people living with HIV/AIDS, PLWHA) with the purpose of obtaining autopsies from high priority cases that are aligned with the three thematic priorities in the RFA: a) HIV eradication from CNS reservoirs; b) mechanisms of HIV-associated neurocognitive disorders (HAND) in the setting of long-term HAART, and c) understanding comorbidities associated with HIV, including the effects of aging and chronic HIV-infection. CNTN will accumulate and manage a bank of in-life (plasma, CSF, blood, stool) and autopsy (brain, heart, lung, liver, kidney, lymph node, blood, and CSF) specimens and data from a cohort of persons living with HIV who are well characterized neuropsychologically, neuromedically, and psychiatrically. CNTN will additionally collect tissues (e.g., gut lymphoid tissue, testes) for emerging CNS cure and eradication research, and stool for microbiome research. Unique within the NNTC, the CNTN has assumed responsibility for CNS HIV-1 Antiretroviral Therapy Effects Research (CHARTER) specimens including plasma, CSF, buccal swabs, skin biopsies, and nucleic acids. De-identified CHARTER data sets (clinical, laboratory, genetic, neuroimaging, and research) have been transferred to the NNTC Data Coordinating Center (DCC), where they are now maintained. CNTN will maintain both the CNTN and CHARTER specimen resource abiding by strict quality assurance and quality control procedures, and will provide timely transfer of data and specimen inventories to the NNTC Data Coordinating Center (DCC). External requests for de-identified CNTN or CHARTER data or specimens are now managed by the DCC in collaboration with NNTC sites, and the CNTN team is well equipped to provide timely distribution of both CNTN and CHARTER specimens according to NNTC data and resource distribution policies. Finally, CNTN will continue to be an active collaborating member of the NNTC by: coordinating with the DCC and other NNTC sites; providing scientific and technical expertise to the wider research community as a voting member of the NNTC Steering Committee (SC), which reviews requests for data and specimens to facilitate neuroAIDS research; and as the leader of the NNTC Neuropsychology/Psychiatry subcommittee. Through the accomplishment of these objectives, the CNTN will continue to be a national and international resource serving the needs of neuroAIDS investigators.