AIDS Tricombination Therapies Subproject 1

艾滋病三组合疗法子项目1

• 批准号: 9915363
• 负责人: CHARLES HEBERT
• 金额: $ 240万
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-23 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915363
• 关键词: AIDS therapy; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adult; Adverse effects; Animals; Biological Markers; Birth; Bone Development; Chemicals; Clinical; Communities; Congenital Abnormality; Developing Countries; Development; Dose; Drug Combinations; Drug usage; Environmental Pollution; Exhibits; Exposure to; FDA approved; Fetal Development; Fetal Weight; Flame Retardants; Generations; Goals; HIV Seropositivity; Hazard Identification; Hazardous Chemicals; Health; Human; Individual; Industrialization; Infertility; Investigation; Laboratory Animals; Laboratory Rat; Laboratory mice; Lamivudine; Life; Materials Testing; Medical; Monitor; National Toxicology Program; Neural tube; Ovary; Patients; Pharmaceutical Preparations; Primates; Puberty; Rattus; Rodent; Safety; Stavudine; Tenofovir; Testis; Therapeutic; Toxic effect; Toxicity Tests; Weight Gain; Woman; World Health Organization; Zidovudine; abacavir; compliance behavior; critical period; design; dietary supplements; disorder prevention; early life exposure; efavirenz; emtricitabine; fetal; in utero; medication safety; mortality; neurodevelopment; offspring; personal care products; postnatal development; pregnant; prenatal exposure; programs; public health research; reproductive organ; reproductive toxicity; tumor

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. This program is designed to evaluate toxicity following early life exposure to chemicals. For this project, laboratory rats and mice are exposed to various test materials during fetal development and exposures may continue after birth and through adulthood. Animals are evaluated for adverse effects at different stages of life for effects such as changes in onset of puberty, infertility or other reproductive toxicity such as adverse effects on reproductive organs including ovaries or testes, and development of tumors. Examples of chemical classes studied include personal care product ingredients, flame retardants, dietary supplements, industrial chemicals, environmental contaminants and drugs including AIDS therapies.

该项目的目标是为国家毒理学计划（NTP）的危害识别活动提供支持，这些活动旨在预防因接触化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。该计划旨在评估早期接触化学品后的毒性。 在该项目中，实验室大鼠和小鼠在胎儿发育期间暴露于各种试验材料，并可能在出生后和成年后继续暴露。在生命的不同阶段评价动物的不良反应，如青春期开始的变化、不育或其他生殖毒性，如对生殖器官（包括卵巢或睾丸）的不良反应和肿瘤的发展。研究的化学品类别包括个人护理产品成分，阻燃剂，膳食补充剂，工业化学品，环境污染物和药物，包括艾滋病治疗。