AIDS Tricombination Therapies Subproject 1

艾滋病三组合疗法子项目1

基本信息

批准号：
9915363
负责人：
CHARLES HEBERT
金额：
$ 240万
依托单位：
SOUTHERN RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-23 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9915363
关键词：
AIDS therapy AIDS/HIV problem Acquired Immunodeficiency Syndrome Adult Adverse effects Animals Biological Markers Birth Bone Development Chemicals Clinical Communities Congenital Abnormality Developing Countries Development Dose Drug Combinations Drug usage Environmental Pollution Exhibits Exposure to FDA approved Fetal Development Fetal Weight Flame Retardants Generations Goals HIV Seropositivity Hazard Identification Hazardous Chemicals Health Human Individual Industrialization Infertility Investigation Laboratory Animals Laboratory Rat Laboratory mice Lamivudine Life Materials Testing Medical Monitor National Toxicology Program Neural tube Ovary Patients Pharmaceutical Preparations Primates Puberty Rattus Rodent Safety Stavudine Tenofovir Testis Therapeutic Toxic effect Toxicity Tests Weight Gain Woman World Health Organization Zidovudine abacavir compliance behavior critical period design dietary supplements disorder prevention early life exposure efavirenz emtricitabine fetal in utero medication safety mortality neurodevelopment offspring personal care products postnatal development pregnant prenatal exposure programs public health research reproductive organ reproductive toxicity tumor

项目摘要

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. This program is designed to evaluate toxicity following early life exposure to chemicals. For this project, laboratory rats and mice are exposed to various test materials during fetal development and exposures may continue after birth and through adulthood. Animals are evaluated for adverse effects at different stages of life for effects such as changes in onset of puberty, infertility or other reproductive toxicity such as adverse effects on reproductive organs including ovaries or testes, and development of tumors. Examples of chemical classes studied include personal care product ingredients, flame retardants, dietary supplements, industrial chemicals, environmental contaminants and drugs including AIDS therapies.

该项目的目的是提供针对预防疾病或因化学物质或物理剂引起的疾病或不良影响的国家毒理学计划（NTP）危害识别活动的支持。毒性测试是公共卫生研究的重要方面，它有助于识别对人类健康有害的化学物质。该计划旨在评估早期寿命暴露于化学物质后的毒性。对于该项目，实验室大鼠和小鼠在胎儿发育过程中暴露于各种测试材料中，出生后和成年后可能会继续暴露。评估动物在生活的不同阶段的不良反应，例如青春期，不育症或其他生殖毒性的变化，例如对卵巢或睾丸在内的生殖器官的不良影响以及肿瘤的发展。所研究的化学类别的实例包括个人护理产品成分，阻燃剂，饮食补充剂，工业化学品，环境污染物和包括艾滋病疗法在内的药物。