AIDS Subproject: Resveratrol Subproject 3

艾滋病子项目：白藜芦醇子项目3

• 批准号: 10616453
• 负责人: CHARLES HEBERT
• 金额: $ 40万
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-23 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10616453
• 关键词: AIDS therapy; Acquired Immunodeficiency Syndrome; Adult; Adverse effects; Animals; Birth; Chemicals; Development; Drug Kinetics; Environmental Pollution; Exposure to; Fetal Development; Flame Retardants; Goals; HIV; Hazardous Chemicals; Health; Human; Industrialization; Infertility; Laboratory Rat; Laboratory mice; Life; Materials Testing; Mus; National Institute of Environmental Health Sciences; National Toxicology Program; Ovary; Pharmaceutical Preparations; Puberty; Rattus; Reproduction; Resveratrol; Rodent; Safety; Testis; Therapeutic; Toxic effect; Toxicity Tests; absorption; adverse outcome; body system; design; dietary supplements; disorder prevention; early life exposure; personal care products; preclinical toxicity; prenatal exposure; programs; public health research; reproductive organ; reproductive toxicity; safety assessment; trans-resveratrol; tumor

The goal of this project is to provide support of National Toxicology Program (NTP) activities targeted toward the prevention of diseases or adverse effects caused by exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. This program is designed to evaluate toxicity following early life exposure to chemicals. For this project, laboratory rats and mice are exposed to various test materials during fetal development and exposures may continue after birth and through adulthood. Animals are evaluated for adverse effects at different stages of life for effects such as changes in onset of puberty, infertility or other reproductive toxicity such as adverse effects on reproductive organs including ovaries or testes, and development of tumors or other adverse outcomes. Examples of chemical classes studied include personal care product ingredients, flame retardants, dietary supplements, industrial chemicals, environmental contaminants and drugs including AIDS therapies.

该项目的目标是为国家毒理学计划（NTP）的活动提供支持，以预防因暴露于化学或物理剂而引起的疾病或不良影响。毒性试验是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。该计划旨在评估早期接触化学品后的毒性。