AIDS Combination Therapy Subproject 2

艾滋病联合治疗子项目2

基本信息

批准号：
10833986
负责人：
CHARLES HEBERT
金额：
$ 22万
依托单位：
SOUTHERN RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-23 至 2023-09-22
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10833986
关键词：
AIDS therapy Acquired Immunodeficiency Syndrome Adult Adverse effects Age Years Animals Birth Cardiovascular Diseases Cardiovascular system Chemicals Childhood Chronic Combined Modality Therapy Data Development Disease Dose Environmental Pollutants Exposure to Female Fetal Development Flame Retardants Goals HIV HIV Seronegativity HIV Seropositivity HIV therapy Hazardous Chemicals Health Human Individual Industrialization Infection Infertility Laboratory Rat Laboratory mice Lamivudine Life Long-Term Effects Materials Testing Mitochondria National Toxicology Program Newborn Infant Organ Organelles Ovary Patients Perinatal Exposure Pharmaceutical Preparations Population Pregnancy Pregnant Women Prophylactic treatment Puberty Rattus Recommendation Study models System Testis Toxic effect Toxicity Tests abacavir adverse outcome antiretroviral therapy design dietary supplements disorder prevention early life exposure offspring personal care products postnatal prenatal exposure programs public health research reproductive organ reproductive toxicity tumor

项目摘要

The goal of this project is to provide support of Division of the National Toxicology Program (DNTP) activities targeted toward the prevention of diseases or adverse effects caused by exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. This program is designed to evaluate toxicity following early life exposure to chemicals. For this project, laboratory rats and mice are exposed to various test materials during fetal development and exposures may continue after birth and through adulthood. Animals are evaluated for adverse effects at different stages of life for effects such as changes in onset of puberty, infertility or other reproductive toxicity such as adverse effects on reproductive organs including ovaries or testes, and development of tumors or other adverse outcomes. Examples of chemical classes studied include personal care product ingredients, flame retardants, dietary supplements, industrial chemicals, environmental contaminants and drugs including AIDS therapies.

该项目的目的是提供针对预防疾病或因化学物质或物理剂引起的疾病或不良影响的国家毒理学计划（DNTP）的支持。毒性测试是公共卫生研究的重要方面，它有助于识别对人类健康有害的化学物质。该计划旨在评估早期寿命暴露于化学物质后的毒性。对于该项目，实验室大鼠和小鼠在胎儿发育过程中暴露于各种测试材料中，出生后和成年后可能会继续暴露。评估动物在生活的不同阶段的不良反应，例如青春期，不育或其他生殖毒性的变化，例如对生殖器官（包括卵巢或睾丸）的不利影响，肿瘤或其他不良结果的发展。所研究的化学类别的实例包括个人护理产品成分，阻燃剂，饮食补充剂，工业化学品，环境污染物和包括艾滋病疗法在内的药物。