Other Projects, Deoxynivalenol Subproject 3

其他项目，脱氧雪腐镰刀菌烯醇子项目 3

• 批准号: 9915365
• 负责人: CHARLES HEBERT
• 金额: $ 21.54万
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-23 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915365
• 关键词: Address; Adult; Adverse effects; Animals; Barley; Birth; Boron; Chemicals; Congenital Abnormality; Development; Developmental Toxicant; Exposure to; Fetal Development; Food; Fusarium; Goals; Grain; Hazard Identification; Hazardous Chemicals; Health; Human; Infant; Infant formula; Infertility; Laboratory Rat; Laboratory mice; Life; Materials Testing; Mycotoxins; National Toxicology Program; Ovary; Puberty; Rattus; Reporting; Research; Rice; Testis; Toxic effect; Toxicity Tests; Trichothecenes; deoxynivalenol; design; developmental toxicity; disorder prevention; drinking water; early life exposure; male; prenatal exposure; programs; public health research; reproductive organ; reproductive toxicity; tumor

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. This program is designed to evaluate toxicity following early life exposure to chemicals. For this project, laboratory rats and mice are exposed to various test materials during fetal development and exposures continue after birth and through adulthood. Animals are evaluated for adverse effects at different stages of life for effects such as birth defects, changes in onset of puberty, infertility or other reproductive toxicity such as adverse effects on reproductive organs including ovaries or testes, and development of tumors.

该项目的目标是支持国家毒理学计划(NTP)的危险识别活动，旨在预防因接触化学或物理制剂而导致的疾病或不良反应。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。该计划旨在评估早年接触化学品后的毒性。 在这个项目中，实验室大鼠和小鼠在胎儿发育期间接触到各种测试材料，并在出生后和成年后继续接触。评估动物在不同生命阶段的不利影响，如出生缺陷、青春期开始的变化、不孕或其他生殖毒性，如对包括卵巢或睾丸在内的生殖器官的不利影响，以及肿瘤的发展。