Spirulina oral supplement for enhancing host resilience to virus infection

总体而言：摘要/总结 密西西比大学 (UM) 植物膳食补充剂研究中心 (BDSRC) 专注于 填补与基于螺旋藻的产品 ImmulinaTM 的潜力相关的知识空白，以促进 对流感以及其他呼吸道病毒感染的抵抗力和/或恢复能力。 ImmulinaTM 是一种获得专利的生物测定标准化提取物，浓缩了活性免疫刺激剂 螺旋藻中的化合物，即布劳恩型脂蛋白。隶属于 UM BDSRC 的研究人员 生成的证据支持 ImmulinaTM 的可重复且机械上合理的效果 增强宿主反应，可增强抵抗流感等呼吸道病毒感染的能力。 仅去年在美国，流感就导致 959,000 名患者住院，79,400 人死亡。 在 Ikhlas Khan 博士和 Nirmal Pugh 博士的指导下，UM BDSRC 包括一个完善的 建立了由多学科研究人员组成的协作团队，他们在天然产物、动物 人类疾病、药剂学、免疫学和人类课题研究的模型。 UM BDSRC 将 由一个管理核心、一个植物核心和两个研究项目组成：(1) 解开免疫 ImmulinaTM 的增强作用，以及 (2) ImmulinaTM 口服补充剂对宿主抵抗力的评估 流感病毒感染。 总体具体目标是：（1）最大限度地协调研究人员之间的努力和沟通， 通过良好管理和传播职业发展和传播知识的培训机会 有效的行政核心； (2) 通过以下措施的组合确保 ImmulinaTM 提取物的产品完整性 植物核心内基于生物测定和化学的标准化方法； (3) 确定 ImmulinaTM免疫增强的分子机制及项目中的最佳配方和剂量 1 的小鼠研究可供 UM BDSRC 的其他研究使用； (4) 同时使用鼠标和 随后基于生物标志物的人体模型，确定了 ImmulinaTM 补充剂对 通过项目 2 提高宿主抵抗流感病毒感染致病影响的能力。 行政核心在外部咨询委员会和内部指导委员会的指导下， 将监督 UM BDSRC 的各个方面，包括实现其里程碑的进展、高效 资源分配、与 UM BDSRC 外部研究人员的合作、对其毕业生的监督 学生和博士后研究员，并维护其网站。植物核心成员将工作 与 UM BDSRC 的研究人员密切合作，提供足够数量的标准化 ImmulinaTM 提取并与 CARBON 的其他单位合作开展 ImmulinaTM 的未来功效研究。结果 项目 1 和 2 的结果将有助于为未来的临床疗效试验建立最佳方案。

OVERALL: ABSTRACT/SUMMARY The University of Mississippi (UM) Botanical Dietary Supplements Research Center (BDSRC) is focused on filling in knowledge gaps related to the potential for the Spirulina-based product, ImmulinaTM, to promote resilience against and/or recovery from influenza and, by extension, other respiratory viral infections. ImmulinaTM is a patented bioassay-standardized extract that concentrates the active immunostimulatory compounds in Spirulina, i.e., Braun-type lipoproteins. Researchers affiliated with the UM BDSRC have generated evidence that supports reproducible and mechanistically plausible effects of ImmulinaTM for enhancing host responses that may promote resilience against respiratory viral infections such as influenza. Last year in the U.S. alone, influenza resulted in 959,000 patient hospitalizations and 79,400 deaths. Under the direction of Ikhlas Khan, PhD and Nirmal Pugh, PhD, the UM BDSRC includes a well- established collaborative team of multi-disciplinary investigators with expertise in natural products, animal models of human diseases, pharmaceutics, immunology, and human subject research. The UM BDSRC will be composed of an Administration Core, a Botanical Core, and two research projects: (1) Unraveling Immune Enhancement by ImmulinaTM, and (2) Evaluation of ImmulinaTM Oral Supplement for Host Resistance to Influenza Virus Infection. The overall specific aims are to: (1) maximize coordination of effort, communication among researchers, training opportunities for career development, and dissemination of knowledge through a well-managed and effective Administrative Core; (2) ensure product integrity of the ImmulinaTM extract through a combination of bioassay- and chemical-based approaches for standardization within the Botanical Core; (3) determine the molecular mechanism of immune enhancement of ImmulinaTM and optimal formulation and dosing in Project 1’s mouse study that can be utilized by the UM BDSRC’s other studies; and (4) using both a mouse and subsequently a biomarker-based human model, establish the impact of ImmulinaTM supplementation on increasing host resilience against the pathogenic effects of influenza virus infection with Project 2. The Administrative Core, guided by an External Advisory Committee and an Internal Steering Committee, will oversee all aspects of the UM BDSRC, including progress towards meeting its milestones, efficient allocation of resources, collaborations with researchers outside the UM BDSRC, oversight of its graduate students and post-doctoral fellows, and maintenance of its website. Members of the Botanical Core will work closely with researchers from the UM BDSRC to provide sufficient quantities of standardized ImmulinaTM extract and to collaborate with other units of CARBON on future efficacy studies of ImmulinaTM. The results from Projects 1 and 2 will help establish the optimal regimen for future clinical efficacy trials.