Spirulina oral supplement for enhancing host resilience to virus infection

螺旋藻口服补充剂可增强宿主对病毒感染的抵抗力

• 批准号: 10447026
• 负责人: Ikhlas Ahmad Khan
• 金额: $ 118.76万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10447026
• 关键词: Address; Advisory Committees; Animal Model; Antiviral Therapy; Asthma; Biological Assay; Biological Markers; Botanical dietary supplements; Botanicals; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chemicals; Clinical Immunology; Clinical Research; Clinical Trials; Clinical trial protocol document; Collaborations; Communication; Data; Doctor of Philosophy; Dose; Drug Delivery Systems; Ensure; Evaluation; Formulation; Future; Hospitalization; Host resistance; Human; Human Subject Research; Hypersensitivity; Immune; Immune response; Immunology; In Vitro; Influenza; Intervention Studies; Knowledge; Learning; Legal patent; Lipoproteins; Liquid substance; Maintenance; Medical center; Medicine; Mississippi; Modeling; Modernization; Molecular; Mus; Natural Products; Outcome Measure; Pathogenicity; Patients; Persons; Pharmacodynamics; Pharmacy (field); Population; Postdoctoral Fellow; Powder dose form; Property; Prophylactic treatment; Recovery; Regimen; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resource Allocation; Scientist; Seasons; Spirulina preparation; Standardization; Structure; Supplementation; Therapeutic; Time; Universities; Viral Respiratory Tract Infection; Virus Diseases; Work; base; burden of illness; career development; design; efficacy clinical trial; efficacy study; feeding; flu; graduate student; human disease; human model; immune health; improved; infection risk; influenza infection; influenza virus vaccine; meetings; member; mid-career faculty; multidisciplinary; oral supplementation; prevent; professor; programs; resilience; seasonal influenza; socioeconomics; synergism; training opportunity; web site

OVERALL: ABSTRACT/SUMMARY The University of Mississippi (UM) Botanical Dietary Supplements Research Center (BDSRC) is focused on filling in knowledge gaps related to the potential for the Spirulina-based product, ImmulinaTM, to promote resilience against and/or recovery from influenza and, by extension, other respiratory viral infections. ImmulinaTM is a patented bioassay-standardized extract that concentrates the active immunostimulatory compounds in Spirulina, i.e., Braun-type lipoproteins. Researchers affiliated with the UM BDSRC have generated evidence that supports reproducible and mechanistically plausible effects of ImmulinaTM for enhancing host responses that may promote resilience against respiratory viral infections such as influenza. Last year in the U.S. alone, influenza resulted in 959,000 patient hospitalizations and 79,400 deaths. Under the direction of Ikhlas Khan, PhD and Nirmal Pugh, PhD, the UM BDSRC includes a well- established collaborative team of multi-disciplinary investigators with expertise in natural products, animal models of human diseases, pharmaceutics, immunology, and human subject research. The UM BDSRC will be composed of an Administration Core, a Botanical Core, and two research projects: (1) Unraveling Immune Enhancement by ImmulinaTM, and (2) Evaluation of ImmulinaTM Oral Supplement for Host Resistance to Influenza Virus Infection. The overall specific aims are to: (1) maximize coordination of effort, communication among researchers, training opportunities for career development, and dissemination of knowledge through a well-managed and effective Administrative Core; (2) ensure product integrity of the ImmulinaTM extract through a combination of bioassay- and chemical-based approaches for standardization within the Botanical Core; (3) determine the molecular mechanism of immune enhancement of ImmulinaTM and optimal formulation and dosing in Project 1’s mouse study that can be utilized by the UM BDSRC’s other studies; and (4) using both a mouse and subsequently a biomarker-based human model, establish the impact of ImmulinaTM supplementation on increasing host resilience against the pathogenic effects of influenza virus infection with Project 2. The Administrative Core, guided by an External Advisory Committee and an Internal Steering Committee, will oversee all aspects of the UM BDSRC, including progress towards meeting its milestones, efficient allocation of resources, collaborations with researchers outside the UM BDSRC, oversight of its graduate students and post-doctoral fellows, and maintenance of its website. Members of the Botanical Core will work closely with researchers from the UM BDSRC to provide sufficient quantities of standardized ImmulinaTM extract and to collaborate with other units of CARBON on future efficacy studies of ImmulinaTM. The results from Projects 1 and 2 will help establish the optimal regimen for future clinical efficacy trials.

总体：摘要/总结 密西西比大学植物膳食补充剂研究中心（BDSRC） 填补与螺旋藻产品ImmulinaTM的潜力有关的知识空白， 对流感和其他呼吸道病毒感染的抵抗力和/或恢复能力。 ImmulinaTM是一种专利的生物测定标准化提取物， 螺旋藻中的化合物，即，Braun型脂蛋白。隶属于UM BDSRC的研究人员已经 生成的证据支持ImmulinaTM对以下疾病的可重现性和机制上合理的作用： 增强宿主反应，可促进对呼吸道病毒感染如流感的恢复力。 去年仅在美国，流感就导致959，000名患者住院治疗，79，400人死亡。 在Ikhlas Khan博士和尼尔马尔Pugh博士的指导下，UM BDSRC包括一个良好的- 建立了由多学科研究人员组成的合作团队，他们具有天然产品、动物 人类疾病模型、药剂学、免疫学和人体研究。UM BDSRC将在 由一个管理核心，一个植物核心和两个研究项目组成：（1）解开免疫 ImmulinaTM的增强作用，以及（2）ImmulinaTM口服补充剂对宿主抵抗 流感病毒感染。 总体具体目标是：（1）最大限度地协调努力，研究人员之间的沟通， 提供职业发展培训机会，通过管理良好的 有效的管理核心;（2）通过以下组合确保ImmulinaTM提取物的产品完整性 生物测定和化学为基础的方法，在植物核心标准化;（3）确定 ImmulinaTM免疫增强作用的分子机制及项目中的最佳配方和剂量 1的小鼠研究，可用于UM BDSRC的其他研究;和（4）使用小鼠和 随后，基于生物标志物的人类模型，建立ImmulinaTM补充剂对 通过项目2提高宿主对流感病毒感染的致病性影响的复原力。 行政核心在外部咨询委员会和内部指导委员会的指导下， 将监督UM BDSRC的各个方面，包括实现其里程碑的进展， 资源分配，与UM BDSRC以外的研究人员合作，监督其毕业生 学生和博士后研究员，并维护其网站。植物核心的成员将工作 与UM BDSRC的研究人员密切合作，提供足够数量的标准化ImmulinaTM 提取并与碳的其他单位合作，对ImmulinaTM的未来疗效研究。结果 项目1和项目2的研究将有助于为未来的临床疗效试验建立最佳方案。