Brain Aging, AD and Dementia in Low and Middle Income Countries (LMICs) and Low Resource Settings: Gender, Genetics, Risk Factors, Pathophysiology and Prevention

项目总结 生活在低资源环境中的人患阿尔茨海默病和相关痴呆的负担更高 (ADRD)。这不仅是因为ADRD的患病率较高，对其照顾者和家庭的支持较少， 但也是因为居住在低资源地区的不同美国人口对ADRD的了解差距很大 居住在中低收入国家(LMIC)的环境和人口。该计划的目标是 拟议的项目是计划、组织和举办一次国际科学会议，以培养和创造一个 协作工作，共享有关风险、保护因素和研究设计的数据和知识 利用OMICS的进展并分析低资源环境下的ADRD情况和 LMIC，并定义将加速美国和国外少数族裔老龄化研究的重要问题。 为期3天的关于低资源环境和LMIC中的脑老化和痴呆的国际研讨会将是 在肯尼亚内罗毕举行，这是一个中心地理位置，将为来自 发展中国家，特别是非洲。它将建立在前4个月期间开发的专业知识和倡议的基础上 同样将包括来自不同受影响和关切国家的专家发言者，包括 阿根廷、澳大利亚、巴西、加拿大、中国、刚果民主共和国、法国、印度、孟加拉国、日本、肯尼亚、摩洛哥、 尼日利亚、新西兰、荷兰、塞内加尔、新加坡、南非、瑞典、突尼斯、英国、美国、委内瑞拉。 对于这次会议，我们将利用UTRGV阿尔茨海默病S少数民族资源中心的资源 老龄化(AD-RCMAR)，由Pi Gladys Maestre领导，Rajesh Kalaria博士和Dr Rajesh Kalaria博士领导。 来自美国阿尔茨海默病S协会的玛丽亚·卡里罗表示。具体目标是：1.准备科学的 低资源环境下的脑老化与痴呆症与LMICs国际研讨会的计划。2. 会议在肯尼亚内罗毕举行，这是一个触手可及的全球中心枢纽城市和酒店会场，并为 特邀演讲者、其他外国代表和当地与会者，并可供其他人在线访问。 3.在主题集中、可在线访问的互动小组/会议中，确定新的研究和医疗保健如何 可以加强或扩大现有/以前项目的项目或后续行动，以改善研究和 在低资源环境下的不同老龄化人口中执行被确定为高优先级需求的行动 减轻ADRD的负担。4.在低收入地区促进以ADRD为重点的少数群体老龄化研究的事业 资源设置，通过直接指导和初级研究人员的积极参与以及提供网络 机会，并建立国内和国际伙伴关系，以利用互补的研究人员和 机构的利益和优势。5.制作和传播详细的荟萃分析和/或共识 根据会议记录和与会者关于痴呆症影响因素状况的意见编写的报告 流行率/发病率以及预防和改善护理和支持的战略，通过同行审查 发表了一篇论文，举行了四次视频会议，以及2021年阿尔茨海默病S疾病事实与数据报告。

PROJECT SUMMARY People residing in low-resource settings suffer a higher burden of Alzheimer´s disease and related dementias (ADRD). This is due not only to higher prevalence of ADRD and lower support for its caregivers and families, but also due to a significant knowledge gap about ADRD in diverse US populations residing in low-resource settings and populations that reside in low and middle income countries (LMICs). The objective of the proposed project is to plan, organize and conduct an international scientific meeting, to foster and create a collaborative effort to share data and knowledge on risk, protective factors, and study designs taking advantage of the advances in the –OMICS and analyze the ADRD situation in low-resource settings and LMICs, and define important questions that will accelerate minority aging research in the US and abroad. The 3-day International Symposium on Brain Aging & Dementia in Low-Resource Settings and LMICs will be held in Nairobi, Kenya, a central geographic location that will facilitate attendance of researchers from the developing world, particularly Africa. It will build upon expertise and initiatives developed during its 4 prior editions and will similarly include expert speakers from diverse impacted and concerned nations, including Argentina, Australia, Brazil, Canada, China, DR Congo, France, India, Bangladesh, Japan, Kenya, Morocco, Nigeria, New Zealand, Netherlands, Senegal, Singapore, South Africa, Sweden, Tunisia, UK, US, Venezuela. For the conference, we will leverage resources of UTRGV Alzheimer´s Disease Resource Center for Minority Aging (AD-RCMAR), led by PI Gladys Maestre, and the global field leadership of Dr. Rajesh Kalaria, and Dr. María Carrillo from the US-based Alzheimer´s Association. The Specific Aims are to: 1. Prepare the scientific program of the International Symposium on Brain Aging & Dementia in Low-Resource Settings and LMICs. 2 Hold the conference in Nairobi, Kenya, a globally central hub city and hotel venue within reach and travel for invited speakers, other foreign delegates, and local participants, and readily accessible to others online. 3. In topic-focused, online-accessible interactive panels/sessions, identify how new research and healthcare projects or follow-up of existing/prior ones can be enhanced or expanded to improve research and implementation of actions identified as high-priority needs in diverse aging populations in low-resource settings to decrease the burden of ADRD. 4. Promote careers in minority aging research focused on ADRD in low- resource settings, by direct mentoring and active engagement of junior researchers and providing networking opportunities, and forge domestic and international partnerships to leverage complementary researchers’ and agencies’ interests and strengths. 5. Produce and disseminate a detailed meta-analysis and/or consensus report based on conference proceedings and participants' input on the status of factors influencing dementia prevalence/incidence and strategies for prevention and improving care and support, via a peer-reviewed published paper, a series of 4 videoconferences, and the 2021 Alzheimer´s Disease Facts & Figures Report.