Brain Aging, AD and Dementia in Low and Middle Income Countries (LMICs) and Low Resource Settings: Gender, Genetics, Risk Factors, Pathophysiology and Prevention

低收入和中等收入国家 (LMIC) 和资源匮乏环境中的脑衰老、AD 和痴呆症：性别、遗传学、危险因素、病理生理学和预防

• 批准号: 9914747
• 负责人: Maria C Carrillo
• 金额: $ 4.99万
• 依托单位: UNIVERSITY OF TEXAS RIO GRANDE VALLEY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9914747
• 关键词: Academy; Achievement; Address; Africa; African; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Argentina; Australia; Bangladesh; Behavior Therapy; Behavioral Symptoms; Biological Markers; Brazil; Canada; Caregivers; Caring; China; Cities; Collaborations; Congo; Consensus; Country; Dementia; Discipline; Disease; Educational workshop; Epidemiological trend; Epidemiology; Etiology; Event; Family; Fostering; Foundations; France; Frequencies; Functional disorder; Funding; Future; Gender; Geographic Locations; Goals; Health; Health Status; Healthcare; High Prevalence; Incidence; Income; India; Individual; Institutes; International; Japan; Kenya; Knowledge; Knowledge acquisition; Leadership; Locales; Mental Health; Mentors; Meta-Analysis; Minority; Morocco; Netherlands; Neurology; New Zealand; Nigeria; Paper; Participant; Population; Population Heterogeneity; Prevalence; Prevention; Prevention strategy; Productivity; Public Health; Publishing; Publishing Peer Reviews; Recurrence; Reporting; Research; Research Design; Research Personnel; Research Training; Resources; Risk; Risk Factors; Schedule; Senegal; Series; Singapore; South Africa; Support System; Sweden; Texas; Time; Travel; Tunisia; Universities; Ursidae Family; Venezuela; Videoconferences; aging brain; base; career; caregiving; cerebrovascular; data sharing; disability; effective intervention; experience; follow-up; genetic risk factor; high risk; implementation science; improved; innovation; interest; international partnership; low and middle-income countries; meetings; multidisciplinary; outcome forecast; programs; protective factors; rural area; social; success; symposium

PROJECT SUMMARY People residing in low-resource settings suffer a higher burden of Alzheimer´s disease and related dementias (ADRD). This is due not only to higher prevalence of ADRD and lower support for its caregivers and families, but also due to a significant knowledge gap about ADRD in diverse US populations residing in low-resource settings and populations that reside in low and middle income countries (LMICs). The objective of the proposed project is to plan, organize and conduct an international scientific meeting, to foster and create a collaborative effort to share data and knowledge on risk, protective factors, and study designs taking advantage of the advances in the –OMICS and analyze the ADRD situation in low-resource settings and LMICs, and define important questions that will accelerate minority aging research in the US and abroad. The 3-day International Symposium on Brain Aging & Dementia in Low-Resource Settings and LMICs will be held in Nairobi, Kenya, a central geographic location that will facilitate attendance of researchers from the developing world, particularly Africa. It will build upon expertise and initiatives developed during its 4 prior editions and will similarly include expert speakers from diverse impacted and concerned nations, including Argentina, Australia, Brazil, Canada, China, DR Congo, France, India, Bangladesh, Japan, Kenya, Morocco, Nigeria, New Zealand, Netherlands, Senegal, Singapore, South Africa, Sweden, Tunisia, UK, US, Venezuela. For the conference, we will leverage resources of UTRGV Alzheimer´s Disease Resource Center for Minority Aging (AD-RCMAR), led by PI Gladys Maestre, and the global field leadership of Dr. Rajesh Kalaria, and Dr. María Carrillo from the US-based Alzheimer´s Association. The Specific Aims are to: 1. Prepare the scientific program of the International Symposium on Brain Aging & Dementia in Low-Resource Settings and LMICs. 2 Hold the conference in Nairobi, Kenya, a globally central hub city and hotel venue within reach and travel for invited speakers, other foreign delegates, and local participants, and readily accessible to others online. 3. In topic-focused, online-accessible interactive panels/sessions, identify how new research and healthcare projects or follow-up of existing/prior ones can be enhanced or expanded to improve research and implementation of actions identified as high-priority needs in diverse aging populations in low-resource settings to decrease the burden of ADRD. 4. Promote careers in minority aging research focused on ADRD in low- resource settings, by direct mentoring and active engagement of junior researchers and providing networking opportunities, and forge domestic and international partnerships to leverage complementary researchers’ and agencies’ interests and strengths. 5. Produce and disseminate a detailed meta-analysis and/or consensus report based on conference proceedings and participants' input on the status of factors influencing dementia prevalence/incidence and strategies for prevention and improving care and support, via a peer-reviewed published paper, a series of 4 videoconferences, and the 2021 Alzheimer´s Disease Facts & Figures Report.

项目摘要 居住在低资源环境中的人患阿尔茨海默病和相关痴呆症的负担更高 （ADRD）.这不仅是由于ADRD的患病率较高以及对其护理人员和家庭的支持较低， 但也是由于居住在低资源地区的不同美国人群对ADRD的知识存在重大差距， 居住在低收入和中等收入国家（LMIC）的环境和人口。的目的 拟议的项目是计划、组织和举办一次国际科学会议， 共同努力，分享有关风险、保护因素和研究设计的数据和知识， 利用-OMICS的进步，分析资源匮乏环境下的ADRD情况， LMICs，并定义将加速美国和国外少数民族老龄化研究的重要问题。 为期3天的低资源环境和低收入国家脑老化和痴呆症国际研讨会将于 内罗毕内罗毕举行，这是一个中心地理位置， 发展中国家，尤其是非洲。它将利用其前4年期间发展的专门知识和倡议， 同样，来自不同受影响和相关国家的专家发言人也将参加， 阿根廷、澳大利亚、巴西、加拿大、中国、刚果民主共和国、法国、印度、孟加拉国、日本、肯尼亚、摩洛哥、 尼日利亚、新西兰、荷兰、塞内加尔、新加坡、南非、瑞典、突尼斯、英国、美国、委内瑞拉。 对于会议，我们将利用UTRGV阿尔茨海默病资源中心的资源，为少数民族 由PI Gladys Maestre领导的AD-RCMAR，以及Rajesh Kalaria博士和Dr. 来自美国阿尔茨海默氏症协会的María Carrillo。具体目标是：1.准备科学 在低资源环境和低收入国家的脑老化和痴呆症国际研讨会的计划。2 在肯尼亚内罗毕举行会议，内罗毕是全球中心枢纽城市和酒店场地， 邀请演讲者、其他外国代表和当地与会者，其他人随时可以在线访问。 3.在以主题为中心的在线交互式小组/会议中，确定新的研究和医疗保健 项目或现有/先前项目的后续行动可以得到加强或扩大，以改进研究， 在资源匮乏的环境中执行被确定为各种老龄人口高度优先需要的行动 减轻ADRD的负担。4.促进少数民族老龄化研究的职业生涯，重点是低- 通过直接指导和青年研究人员的积极参与以及建立网络， 机会，并建立国内和国际伙伴关系，以利用互补的研究人员和 机构的利益和优势。5.制作和传播详细的荟萃分析和/或共识 根据会议记录和与会者对痴呆症影响因素状况的投入编写的报告 流行率/发病率以及预防和改善护理和支助的战略， 发表的论文，一系列的4个视频会议，以及2021年阿尔茨海默病的事实和数据报告。

项目成果

Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization.

拉丁美洲预防认知衰退生活方式干预倡议 (LatAm-FINGERS)：研究设计和协调。

• DOI: 10.1002/alz.13101
• 发表时间: 2023
• 期刊: Alzheimer's & dementia : the journal of the Alzheimer's Association
• 作者: Crivelli,Lucia;Calandri,IsmaelLuis;Suemoto,ClaudiaKimie;Salinas,RosaMaría;Velilla,LinaMarcela;Yassuda,MônicaSanches;Caramelli,Paulo;Lopera,Francisco;Nitrini,Ricardo;Sevlever,GustavoEmilio;Sosa,AnaLuisa;Acosta,Daisy;Baietti,
• 通讯作者: Baietti,