Black Male Brain Reserve, Resilience & Alzheimer’s Disease: Life Course Perspectives

项目概要/摘要： 美国通过创新研究投入了大量资源， 阿尔茨海默病和阿尔茨海默病及相关痴呆症（AD/ADRD）对家庭和社会的影响， 但是黑人男性在历史上并没有从这项研究中充分享受到科学进步的好处。为 例如，由于可预防的疾病，非西班牙裔黑人男性的健康状况下降，发病率增加 (e.g.,心脏病，糖尿病，高血压）和预期寿命短于他们的白色男性同行 此外，老年黑人男性比白人更容易跌倒并持续TBI，这增加了TBI的风险。 随后大脑的脆弱性和痴呆症的风险。虽然老年痴呆症的患病率在 美国黑人比白人高出两到三倍，完全了解这种健康的原因 差距仍然难以把握。缺乏一支训练有素、多学科的科学工作队伍， 全方位的生物学、生物医学、行为学和健康科学方法来解决AD/ADRD健康差异 研究阻碍了这一群体的创新。这一问题因持续的不足而更加复杂- 美国黑人男性在生物医学领域的代表性。在这三年的会议系列中， 多学科学者将与来自美国各地的新兴调查人员一起解决 特定的文化，社会和行为因素，有助于在这个人群中的一些人更 认知能力强，患阿尔茨海默病的风险比其他人低。学者项目的学生将 加强NIA健康差异研究框架（HDRF），包括基于经验的 对黑人男性经历作出反应的因素，以及注重努力改善招聘和 保留战略，从这个人口参与老龄化研究。的基本特征 会议系列将使社区利益相关者参与进来（例如，NFL校友会，男性健康 网络，皮内拉斯县卫生部）在多个方面的会议设计，规划和 实施包括科学家的选择，提供对会议报告的反馈，以及 传播。会议的规划、执行、参与和评价将包括： 来自历史上代表性不足的群体的个人会议系列的目的是：（1）解决 认知储备、复原力和AD/ADRD健康差异方面的知识差距，并确定未来的优先事项 黑人男性的生命历程研究;（2）培养一支受过培训的文化能力强的劳动力队伍， 致力于解决黑人男性的大脑健康，认知老化和AD/ADRD研究，（3）建立一个 黑人男性多地点研究志愿者登记处。这些举措有助于支持重要的工作， 与行为健康和社会研究（BSR）在NIA内的部门的目标，以实现健康 公平，消除差距，改善所有群体的健康。

Project Summary/Abstract: The United States has invested significant resources through innovative research to address the profound effects of Alzheimer’s Disease, and Alzheimer’s Disease and Related Dementias (AD/ADRD) on families and society, but Black males historically have not experienced the full benefits of scientific advances from that research. For example, non-Hispanic Black men have diminished health and increased morbidity due to preventable diseases (e.g., cardiac, diabetes, high blood pressure) and shorter life expectancies than their White male counterparts Additionally, elderly Black men are more likely to fall and sustain a TBI than whites, which increases the subsequent vulnerability of the brain and risk of dementia. Although the prevalence of Alzheimer’s disease in Black Americans is two to three times higher than Whites, a complete understanding of the cause of this health disparity remains elusive. The lack of a highly trained, multidisciplinary scientific workforce that addresses the full range of biological, biomedical, behavioral, and health sciences approaches to AD/ADRD health disparities research hinders innovation among this population. This problem is compounded by the persistent under- representation of Black American males in biomedical. During this three-year conference series, leading multidisciplinary scholars will come together with emerging investigators from across the U.S. to address specific cultural, social and behavioral factors that contribute to some individuals in this population being more cognitively resilient and experience a reduced risk of developing Alzheimer’s disease than others. Scholars will enhance the NIA Health Disparities Research Framework (HDRF) with the inclusion of empirically based factors that are responsive to the Black male experience, as well as focus on efforts to improve recruitment and retention strategies for participation from this population in aging research. An essential feature of the conference series will be to engage community stakeholders (e.g., NFL Alumni Association, Men’s Health Network, Pinellas County Health Department) in multiple aspects of the conference design, planning and implementation including the selection of scientists, providing feedback on conference presentations, and dissemination. Planning, implementation, participation and evaluation of the conference will incorporate individuals from historically underrepresented groups The aims of the conference series are: (1) to address knowledge gaps and identify future priorities in cognitive reserve, resilience, and AD/ADRD health disparities life course research among Black males; (2) to cultivate a culturally competent workforce trained and committed to addressing Black male’s brain health, cognitive aging, and AD/ADRD research, (3) build a multisite research volunteer registry of Black males. These initiatives help support important work that align with the goals of the Division of Behavioral Health and Society Research (BSR) within NIA, to achieve health equity, eliminate disparities, and improve the health of all groups.