Black Male Brain Reserve, Resilience & Alzheimer’s Disease: Life Course Perspectives

黑人男性大脑储备、恢复能力

• 批准号: 10153020
• 负责人: Maria C Carrillo
• 金额: $ 4.98万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-15 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10153020
• 关键词: Address; Adult; African American; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Applications Grants; Athletic; Attention; Attitude; Award; Awareness; Behavioral; Behavioral Sciences; Belief; Biological; Biomedical Research; Brain; Cardiac; Cognitive; Cognitive aging; Communities; Consultations; County; Development; Diabetes Mellitus; Disease; Documentation; Elderly; Environmental Exposure; Evaluation; Family; Feedback; Fellowship; Foundations; Future; Gender; Goals; Health; Health Sciences; Health Status; Hypertension; Individual; Institutes; Knowledge; Leadership; Life Cycle Stages; Life Expectancy; Longevity; Manufactured football; Manuscripts; Mental Depression; Mental Health; Mentors; Michigan; Modeling; Morbidity - disease rate; Not Hispanic or Latino; Outcome; Personal Satisfaction; Population; Prevalence; Public Health; Publishing; Recommendation; Registries; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Science; Scientific Advances and Accomplishments; Scientist; Series; Societies; Time; Training; Translating; Translational Research; Traumatic Brain Injury; Underrepresented Populations; United States; Work; aging brain; base; behavioral health; black men; black women; brain health; cardiovascular health; cognitive reserve; cultural competence; dementia care; dementia risk; design; disparity elimination; effective intervention; experience; falls; health care service utilization; health disparity; health equity; health organization; improved; innovation; male; male health; meetings; member; multidisciplinary; psychologic; recruit; resilience; retention rate; social; social culture; symposium; volunteer

Project Summary/Abstract: The United States has invested significant resources through innovative research to address the profound effects of Alzheimer’s Disease, and Alzheimer’s Disease and Related Dementias (AD/ADRD) on families and society, but Black males historically have not experienced the full benefits of scientific advances from that research. For example, non-Hispanic Black men have diminished health and increased morbidity due to preventable diseases (e.g., cardiac, diabetes, high blood pressure) and shorter life expectancies than their White male counterparts Additionally, elderly Black men are more likely to fall and sustain a TBI than whites, which increases the subsequent vulnerability of the brain and risk of dementia. Although the prevalence of Alzheimer’s disease in Black Americans is two to three times higher than Whites, a complete understanding of the cause of this health disparity remains elusive. The lack of a highly trained, multidisciplinary scientific workforce that addresses the full range of biological, biomedical, behavioral, and health sciences approaches to AD/ADRD health disparities research hinders innovation among this population. This problem is compounded by the persistent under- representation of Black American males in biomedical. During this three-year conference series, leading multidisciplinary scholars will come together with emerging investigators from across the U.S. to address specific cultural, social and behavioral factors that contribute to some individuals in this population being more cognitively resilient and experience a reduced risk of developing Alzheimer’s disease than others. Scholars will enhance the NIA Health Disparities Research Framework (HDRF) with the inclusion of empirically based factors that are responsive to the Black male experience, as well as focus on efforts to improve recruitment and retention strategies for participation from this population in aging research. An essential feature of the conference series will be to engage community stakeholders (e.g., NFL Alumni Association, Men’s Health Network, Pinellas County Health Department) in multiple aspects of the conference design, planning and implementation including the selection of scientists, providing feedback on conference presentations, and dissemination. Planning, implementation, participation and evaluation of the conference will incorporate individuals from historically underrepresented groups The aims of the conference series are: (1) to address knowledge gaps and identify future priorities in cognitive reserve, resilience, and AD/ADRD health disparities life course research among Black males; (2) to cultivate a culturally competent workforce trained and committed to addressing Black male’s brain health, cognitive aging, and AD/ADRD research, (3) build a multisite research volunteer registry of Black males. These initiatives help support important work that align with the goals of the Division of Behavioral Health and Society Research (BSR) within NIA, to achieve health equity, eliminate disparities, and improve the health of all groups.

项目摘要/摘要： 美国通过创新研究投入了大量资源来解决其深远影响 阿尔茨海默病以及阿尔茨海默病和相关痴呆症 (AD/ADRD) 对家庭和社会的影响， 但从历史上看，黑人男性并没有从这项研究中体验到科学进步的全部好处。为了 例如，非西班牙裔黑人男性由于可预防的疾病而健康状况恶化，发病率增加 （例如心脏病、糖尿病、高血压）并且预期寿命比白人男性要短 此外，老年黑人比白人更容易摔倒并遭受创伤性脑损伤，这增加了 随后大脑的脆弱性和痴呆的风险。尽管阿尔茨海默氏病的患病率 美国黑人比白人高两到三倍，彻底了解这种健康的原因 差距仍然难以捉摸。缺乏训练有素、多学科的科学队伍来解决这一问题 针对 AD/ADRD 健康差异的全方位生物学、生物医学、行为和健康科学方法 研究阻碍了这一人群的创新。这个问题因持续的不足而变得更加复杂 美国黑人男性在生物医学领域的代表。在这个为期三年的会议系列中，领导 多学科学者将与来自美国各地的新兴研究人员聚集在一起解决 特定的文化、社会和行为因素导致该人群中的某些人更加 与其他人相比，认知能力更强，患阿尔茨海默病的风险更低。学者们将 加强 NIA 健康差异研究框架 (HDRF)，纳入基于经验的研究 对黑人男性经历做出反应的因素，以及重点努力改善招聘和 保留该人群参与老龄化研究的策略。的一个基本特征 系列会议将吸引社区利益相关者（例如 NFL 校友会、男性健康协会） 网络、皮内拉斯县卫生局）在会议设计、策划和多个方面进行了 实施，包括选择科学家、提供会议报告反馈，以及 传播。会议的策划、实施、参与和评估将包括 来自历史上代表性不足群体的个人 该系列会议的目的是：(1) 解决 知识差距并确定认知储备、复原力和 AD/ADRD 健康差异方面的未来优先事项 黑人男性生命历程研究； （二）培养一支受过训练、有文化素质的劳动力队伍 致力于解决黑人男性的大脑健康、认知衰老和 AD/ADRD 研究，(3) 建立 黑人男性多站点研究志愿者登记册。这些举措有助于支持重要的工作 遵循 NIA 行为健康与社会研究部 (BSR) 的目标，实现健康 公平，消除差距，改善所有群体的健康。