Black Male Brain Reserve, Resilience & Alzheimer’s Disease: Life Course Perspectives

项目摘要/摘要： 美国通过创新研究投入了大量资源，以应对这一深刻影响 阿尔茨海默病、阿尔茨海默病和相关痴呆(AD/ADRD)对家庭和社会的影响， 但从历史上看，黑人男性并没有从这项研究中充分体验到科学进步的好处。为 例如，由于可预防的疾病，非西班牙裔黑人男性的健康状况下降，发病率增加 (例如，心脏病、糖尿病、高血压)和比白人男性更短的预期寿命 此外，老年黑人男性比白人更有可能摔倒并持续脑外伤，这增加了 随后大脑的脆弱性和患痴呆症的风险。尽管阿尔茨海默病在中国的患病率 美国黑人比白人高两到三倍，完全理解这种健康的原因 差距仍然难以捉摸。缺乏一支训练有素、多学科的科学队伍来解决 全方位的生物、生物医学、行为和健康科学方法解决AD/ADRD健康差距 研究阻碍了这一群体的创新。这个问题因持续的不足而变得更加复杂- 美国黑人男性在生物医学领域的代表性。在这个为期三年的会议系列中，领导 多学科学者将与来自美国各地的新兴调查人员一起解决 特定的文化、社会和行为因素，导致这个群体中的一些人 认知能力强，患阿尔茨海默氏症的风险比其他人低。学者们会 增强NIA健康差异研究框架(HDRF)，纳入基于经验的 对黑人男性经历作出反应的因素，以及侧重于努力改善招聘和 这一人群参与老龄化研究的保留策略。的一个基本特征。 会议系列将吸引社区利益相关者(例如，NFL校友协会、男性健康 皮内拉斯县卫生局)在多个方面进行了会议的设计、策划和 执行工作，包括挑选科学家，对会议发言提供反馈，以及 传播。会议的规划、执行、参与和评价将包括 来自历史上代表性不足的群体的个人会议系列的目标是：(1)解决 知识差距并确定认知储备、恢复力和AD/ADRD健康差距方面的未来优先事项 黑人男性的生命历程研究；(2)培养一支有文化能力的劳动力队伍，经过培训和 致力于解决黑人男性的大脑健康、认知老化和AD/ADRD研究，(3)建立 黑人男性多站点研究志愿者登记。这些计划有助于支持符合以下要求的重要工作 与NIA内行为健康和社会研究(BSR)司的目标是实现健康 公平，消除差异，改善所有群体的健康。

Project Summary/Abstract: The United States has invested significant resources through innovative research to address the profound effects of Alzheimer’s Disease, and Alzheimer’s Disease and Related Dementias (AD/ADRD) on families and society, but Black males historically have not experienced the full benefits of scientific advances from that research. For example, non-Hispanic Black men have diminished health and increased morbidity due to preventable diseases (e.g., cardiac, diabetes, high blood pressure) and shorter life expectancies than their White male counterparts Additionally, elderly Black men are more likely to fall and sustain a TBI than whites, which increases the subsequent vulnerability of the brain and risk of dementia. Although the prevalence of Alzheimer’s disease in Black Americans is two to three times higher than Whites, a complete understanding of the cause of this health disparity remains elusive. The lack of a highly trained, multidisciplinary scientific workforce that addresses the full range of biological, biomedical, behavioral, and health sciences approaches to AD/ADRD health disparities research hinders innovation among this population. This problem is compounded by the persistent under- representation of Black American males in biomedical. During this three-year conference series, leading multidisciplinary scholars will come together with emerging investigators from across the U.S. to address specific cultural, social and behavioral factors that contribute to some individuals in this population being more cognitively resilient and experience a reduced risk of developing Alzheimer’s disease than others. Scholars will enhance the NIA Health Disparities Research Framework (HDRF) with the inclusion of empirically based factors that are responsive to the Black male experience, as well as focus on efforts to improve recruitment and retention strategies for participation from this population in aging research. An essential feature of the conference series will be to engage community stakeholders (e.g., NFL Alumni Association, Men’s Health Network, Pinellas County Health Department) in multiple aspects of the conference design, planning and implementation including the selection of scientists, providing feedback on conference presentations, and dissemination. Planning, implementation, participation and evaluation of the conference will incorporate individuals from historically underrepresented groups The aims of the conference series are: (1) to address knowledge gaps and identify future priorities in cognitive reserve, resilience, and AD/ADRD health disparities life course research among Black males; (2) to cultivate a culturally competent workforce trained and committed to addressing Black male’s brain health, cognitive aging, and AD/ADRD research, (3) build a multisite research volunteer registry of Black males. These initiatives help support important work that align with the goals of the Division of Behavioral Health and Society Research (BSR) within NIA, to achieve health equity, eliminate disparities, and improve the health of all groups.