E-cigarette use as a smoking cue
使用电子烟作为吸烟提示
基本信息
- 批准号:9915868
- 负责人:
- 金额:$ 53.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-15 至 2022-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptionAdultAerosolsAffectAgeAppetitive BehaviorAwarenessBehaviorChemicalsCigaretteCigarette SmokerControlled StudyCuesCustomDevicesElectronic Nicotine Delivery SystemsElectronic cigaretteEquationEthicsEventExhalationExposure toFriendsGenerationsGlycerolHandIndividualInhalationInvestigationKnowledgeLaboratoriesLawsMethodologyModelingMovementNicotineOral cavityParticipantPharyngeal structurePilot ProjectsPlayProductionPsychological reinforcementPublic HealthResearchRoleSample SizeSamplingSmokeSmokerSmokingSmoking BehaviorSocial InteractionSocietiesStandardizationStimulusSystemTimeTobaccoTobacco useTrainingVegetablesWaterWorkattentional biasbasebehavioral responsecigarette smokingcue reactivityelectronic cigarette useelectronic liquidevidence basein vivoinclusion criterianon-smokingnovelpreferenceresidenceresponsesecondary outcomesmoking cuevapingvaporvoltageyoung adult
项目摘要
PROJECT SUMMARY/ABSTRACT:
Smoking is an appetitive behavior and stimuli associated with nicotine’s desirable effects have been shown to
increase smoking urge and behavior. As electronic nicotine delivery systems (ENDS, electronic cigarettes, or
e-cigarettes) share salient features of traditional smoking in form and function, it is possible they could
generalize as a conditioned cue to elicit smoking urge and behavior. This is of critical importance as the
availability and rapid adoption of ENDS has led to increased second-hand exposures to vaping that occur in
similar contexts as smoking. Thus, even one occasion of e-cigarette use could conceivably result in numerous
ENDS products have rapidly evolved with increased popularity for tank systems with
variable-voltage/wattage settings. These devices are used in conjunction with e-liquids that include various
chemical constituents, including the primary humectant vegetable glycerin (VG). E-liquids with high levels of
VG are desirable for both the throat hit as well as their ability to increase exhaled aerosol (vape) production
which may affect their cue salience
exposures to observers.
. Well-controlled, evidence-based research is needed to elucidate the role
of e-liquid constituents of ENDS and their aerosols that may affect tobacco use in observers. We propose the
first large-scaled controlled study to address this issue. We will examine current and former smokers’ cue
reactivity to the use of a tank-based ENDS device with different VG content e-liquids. Study 1 will compare
subjective and behavioral responses to the use of ENDS with high vs. low VG e-liquids, relative to both a non-
smoking control cue (bottled water) and a cigarette cue (active comparison) in a diverse sample of adult daily
and nondaily smokers (N=320, 80/cue condition). Study 2 will examine subjective responses to the high VG e-
liquid ENDS cue compared to the control and active comparison cues in a sample of former smokers (N=240,
80/cue condition). Smoking behavior and cigarette reinforcement tasks will not be assessed in Study 2 for
ethical reasons as participants are not currently smokers.
Cue exposures will be delivered via a trained
confederate engaging in product use in the presence of the participant. Thus, this paradigm mimics real-world
exposures for ecological validity while retaining standardized cue delivery, hand to mouth movements, and
interaction quality
. The main dependent variables will be cigarette and e-cigarette desire, smoking urge, and
smoking behavior (latency to smoke, smoking choice), as well as secondary outcomes including affect,
cigarette reinforcement and attentional bias. The results will contribute to our scientific knowledge on the
effects of ENDS in terms of the downstream effects of product use. The proposed studies will play a critical
role in determining the role of e-liquid constituents that may factor into the ongoing debate about the ENDS’
potential benefit versus harm. Second-hand exposures to these devices and the salience of their exhaled
aerosols may be an important part of the equation in evaluating the overall effects of ENDS use in society.
项目概要/摘要:
吸烟是一种食欲行为,与尼古丁的理想效果相关的刺激已被证明可以
增加吸烟欲望和行为。作为电子尼古丁输送系统(ENDS、电子烟或
电子烟)在形式和功能上与传统吸烟具有显着特征,因此它们有可能
概括为引发吸烟冲动和行为的条件暗示。这一点至关重要,因为
ENDS 的可用性和快速采用导致二手电子烟暴露增加
与吸烟类似的情况。因此,即使使用电子烟一次也可能会导致无数次的后果。
随着储罐系统的日益普及,ENDS 产品迅速发展,
可变电压/功率设置。这些设备与电子液体结合使用,包括各种
化学成分,包括主要保湿剂植物甘油(VG)。含有高含量的电子液体
VG 既具有击喉感,又具有增加呼出气溶胶 (vape) 产生的能力
这可能会影响他们的提示显着性
暴露给观察者。
。需要进行良好控制、基于证据的研究来阐明其作用
ENDS 的电子液体成分及其气溶胶可能影响观察者的烟草使用。我们建议
第一个大规模对照研究来解决这个问题。我们将检查当前和以前吸烟者的暗示
使用基于罐的 ENDS 设备与不同 VG 含量的电子液体的反应性。研究1将比较
相对于非非烟油,对使用高 VG 电子烟液与低 VG 电子烟液的 ENDS 的主观和行为反应
成人日常不同样本中的吸烟控制线索(瓶装水)和香烟线索(主动比较)
和非日常吸烟者(N=320,80/提示条件)。研究 2 将检验对高 VG e- 的主观反应
液体 ENDS 线索与对照组和前吸烟者样本中主动比较线索的比较(N=240,
80/提示条件)。研究 2 中不会评估吸烟行为和香烟强化任务:
道德原因,因为参与者目前不吸烟。
提示曝光将通过经过培训的人员进行
同盟者在参与者在场的情况下参与产品使用。因此,这个范式模仿了现实世界
暴露生态有效性,同时保留标准化的提示传递、手到嘴的动作,以及
交互质量
。主要因变量是香烟和电子烟的欲望、吸烟的冲动以及
吸烟行为(吸烟潜伏期、吸烟选择),以及次要结果,包括情感、
香烟强化和注意力偏差。研究结果将有助于我们的科学知识
ENDS 对产品使用的下游影响的影响。拟议的研究将发挥关键作用
确定电子液体成分的作用可能会影响有关 ENDS 的持续争论
潜在的好处与危害。对这些设备的二手接触及其呼出的气体的显着性
气溶胶可能是评估电子尼古丁传送系统在社会中使用的总体影响的重要组成部分。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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ANDREA C KING的其他文献
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{{ truncateString('ANDREA C KING', 18)}}的其他基金
ALCOHOL STIMULATION AND SEDATION IN BINGE DRINKERS
酗酒者的酒精刺激和镇静作用
- 批准号:
7604756 - 财政年份:2007
- 资助金额:
$ 53.23万 - 项目类别:
ALCOHOL STIMULATION AND SEDATION IN BINGE DRINKERS
酗酒者的酒精刺激和镇静作用
- 批准号:
7378623 - 财政年份:2006
- 资助金额:
$ 53.23万 - 项目类别:
Efficacy of Naltrexone in Women's Smoking Cessation
纳曲酮对女性戒烟的功效
- 批准号:
7118779 - 财政年份:2005
- 资助金额:
$ 53.23万 - 项目类别:
Efficacy of Naltrexone in Women's Smoking Cessation
纳曲酮对女性戒烟的功效
- 批准号:
7232733 - 财政年份:2005
- 资助金额:
$ 53.23万 - 项目类别:
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