FMRI OF ALCOHOL-INDUCED URGE TO SMOKE

酒精引起的吸烟冲动的 FMRI

• 批准号: 7604785
• 负责人: ANDREA C KING
• 金额: $ 0.11万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604785
• 关键词: Addictive Behavior; Alcohols; Area; Attention; Beverages; Blood alcohol level measurement; Brain; Brain region; Chicago; Cigarette; Computer Retrieval of Information on Scientific Projects Database; Cues; Data; Dopamine; Enrollment; Female; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Image; Institution; Magnetic Resonance Imaging; Participant; Pilot Projects; Placebos; Prefrontal Cortex; Prevention; Research; Research Personnel; Resolution; Resources; Scanning; Smoke; Smoker; Smoking; Source; System; United States National Institutes of Health; Universities; Visual; Visuospatial; base; brain research; craving; desire; drinking; drug of abuse; male

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While drinking and smoking are highly associated addictive behaviors, little is known about brain activity involved in alcohol-induced desire to smoke. Therefore, this pilot study aims to utilize functional magnetic resonance imaging (fMRI) in order to discern brain regions activated by alcohol in the presence of visual smoking cues. It is predicted that areas that have been shown to be activated by other drugs of abuse, including mesolimbic dopamine, prefrontal cortex, and areas related to visuospatial attention will be particularly activated after alcohol compared to placebo beverage. The goal will be to enroll n=14 (7 male and 7 female) habitual drinker-smoker participants. Scanning will be performed at the University of Chicago Brain Research Imaging Center (BRIC) on a 3.0 Tesla GE Signa System (Milwaukee, WI). Subjects will complete standardized scales of cigarette craving at pre-drink baseline and during fMRI scanning, before and after presentation of both neutral and smoking-related visual cues. High resolution functional imaging will be obtained during the interval when blood alcohol levels are rising and peak increases in smoking urges are expected, based on several studies by the PI and her colleagues. The data will provide information on brain activity underlying cigarette craving increased by alcohol. The ultimate goal of this research is to help target treatment and prevention efforts to reduce concurrent heavy use of both substances.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 虽然饮酒和吸烟与成瘾行为高度相关，但人们对酒精引起的吸烟欲望所涉及的大脑活动知之甚少。 因此，这项试点研究旨在利用功能磁共振成像（fMRI）来识别在视觉吸烟线索存在的情况下由酒精激活的大脑区域。 据预测，与安慰剂饮料相比，已被其他滥用药物激活的区域，包括中脑边缘多巴胺、前额皮质和与视觉空间注意力相关的区域，在饮酒后将特别被激活。 目标是招募 n=14 名（7 名男性和 7 名女性）习惯性饮酒/吸烟的参与者。 扫描将在芝加哥大学脑研究成像中心 (BRIC) 的 3.0 Tesla GE Signa 系统（威斯康星州密尔沃基）上进行。 受试者将在饮酒前基线和功能磁共振成像扫描期间、在呈现中性和吸烟相关视觉线索之前和之后完成吸烟渴望的标准化量表。 根据 PI 及其同事的几项研究，在血液酒精浓度上升和吸烟欲望预计达到峰值期间，将获得高分辨率功能成像。 这些数据将提供有关因酒精而增加对香烟的渴望的大脑活动的信息。这项研究的最终目标是帮助有针对性的治疗和预防工作，以减少同时大量使用这两种物质。