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Interrogating brain circuits that control feeding caused by fasting or by craving

询问控制禁食或渴望引起的进食的大脑回路

基本信息

批准号：
9916637
负责人：
ARSHAD M. KHAN
金额：
$ 36.48万
依托单位：
UNIVERSITY OF TEXAS EL PASO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-01 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9916637
关键词：
Animal Model Area Atlases Base of the Brain Behavior Behavioral Body Weight Brain Brain region Cells Cerebral cortex Data Databases Deposition Desire for food Dorsal Drug Targeting Eating Eating Disorders Fasting Feeding behaviors Female Food Goals Hormones Human Hunger Hyperphagia Hypothalamic structure Image Individual Knowledge Lateral Lateral Hypothalamic Area Location Mammals Maps Mediating Metabolic Diseases Metabolic syndrome Midbrain structure Motor Pathways Neurons Nutritional Obesity Organ Output Population Rattus Rewards Role Scientist Signal Transduction Stomach Structure Techniques Testing Therapeutic Time Validation Ventral Tegmental Area Viral base behavior test brain dysfunction combat craving design experimental study feeding food craving frontal lobe in vivo male neuroinformatics novel optogenetics organizational structure prevent

项目摘要

PROJECT ABSTRACT Neuron populations in the hypothalamus form nodes within a larger distributed network to control multiple aspects of feeding behavior in mammals. The goal of this project is to functionally interrogate newly mapped hypothalamic relay circuits that control feeding behavior. We will employ viral-based tract tracing, optogenetics, chemogenetics, behavioral analyses of feeding, wide-field and multifluorescence imaging, and reference atlas- based mapping; to determine whether these relay circuits in the hypothalamus mediate feeding triggered either by an overnight fast or by craving for rewarding foods. We will deposit all mapped and probed brain circuit locations within an online neuroinformatics database. The hypothalamus has remained a relatively uncharted and poorly defined brain structure that is otherwise critical for feeding behavior. Knowledge of the basic circuit organization of this structure, and its functional/behavioral validation, is critical for scientists to be able to further experimentally manipulate selected sub-populations of neurons in this structure to study various aspects of feeding control. This, in turn, is expected to yield novel targets within the brain suitable for designing rationale therapeutics and treatments to help prevent or mitigate the effects of obesity, overeating, and metabolic disorders.

项目摘要下丘脑中的神经元群体在一个更大的分布式网络中形成节点，以控制哺乳动物摄食行为的方方面面。这个项目的目标是从功能上询问新绘制的地图控制摄食行为的下丘脑继电器电路。我们将使用基于病毒的轨迹追踪，光遗传学，化学遗传学，摄食行为分析，广域和多荧光成像，以及参考图谱- 为了确定下丘脑中的这些继电器回路是否触发了通过通宵禁食或渴望有价值的食物。我们将储存所有被绘制和探测的大脑回路在线神经信息学数据库中的位置。下丘脑仍然是一个相对未知的以及定义不清的大脑结构，这在其他方面对进食行为至关重要。基础知识这种结构的电路组织及其功能/行为验证对于科学家能够为了进一步实验性地操纵这种结构中选定的神经元亚群，以研究各种饲喂控制的各个方面。反过来，这有望在大脑中产生适合设计的新靶点。帮助预防或减轻肥胖、暴饮暴食和新陈代谢影响的基本疗法和治疗方法精神错乱。